Cutaneous external patch for treating dysmenorrhea

A patch and skin technology, applied in the field of external skin patches, can solve the problems of crystallization of drugs, affecting the efficiency and bioavailability of drug transdermal absorption, and unsatisfactory treatment effects, etc.

Inactive Publication Date: 2012-03-14
BEIJING TIDE PHARMA
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

Because indomethacin and albuterol are lipophilic drugs, the water solubility is not good, and the solubility and stability of the drugs dispersed in the hydrophilic polymer are poor. After a period of time, the drugs will crystallize out, which will affect the drug penetration. The efficiency of skin absorption and bioavailability, the clinical treatment effect is not satisfactory

Method used

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  • Cutaneous external patch for treating dysmenorrhea
  • Cutaneous external patch for treating dysmenorrhea
  • Cutaneous external patch for treating dysmenorrhea

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0029] Embodiment 1 The prescription is composed as follows:

[0030] SIS 20 parts by weight

[0031] 40 parts by weight of modified pine water-soluble alkyd resin

[0032] 15 parts by weight of liquid paraffin

[0033] Capsaicin 0.2 parts by weight

[0034] Titanium oxide 7.8 parts by weight

[0035] Methylparaben 1 part by weight

[0036] Propylparaben 0.5 parts by weight

[0037] Azone 12 parts by weight

[0038] Indomethacin 3 parts by weight

[0039] Salbutamol 0.5 parts by weight

[0040] Preparation method: Weigh the raw and auxiliary materials of the prescription amount, heat-melt and mix them under the condition of 120°C by the hot-melt method, and use it as an adhesive after stirring evenly; add the prescribed amount of indomethacin into the above-mentioned adhesive layer Stir and mix with salbutamol to prepare a paste for patch; evenly laminate the paste on the support, freeze-dry, cut and pack to obtain a finished product.

Embodiment 2

[0041] Embodiment 2 prescription forms as follows:

[0042] SIS 40 parts by weight

[0043] 30 parts by weight of hydrogenated rosin

[0044] 15 parts by weight of liquid paraffin

[0045] Capsaicin 0.7 parts by weight

[0046] Titanium oxide 5.8 parts by weight

[0047] 1 part by weight of benzoic acid

[0048] 5 parts by weight of N-methylpyrrolidone

[0049] Flurbiprofen 1.5 parts by weight

[0050] Cloterol 1 part by weight

[0051] Preparation method: Weigh the raw and auxiliary materials of the prescription amount, heat-melt and mix them under the condition of 130°C by the hot-melt method, and use it as an adhesive after stirring evenly; add the flurbiprofen of the prescription amount into the above-mentioned adhesive layer Stir and mix with Cloterol to prepare a paste for patch; layer the paste evenly on a support, freeze-dry, cut and pack to obtain a finished product.

Embodiment 3

[0052] Embodiment 3 prescription forms as follows:

[0053] SIS 25 parts by weight

[0054] Rosin glyceride 50 parts by weight

[0055] 18 parts by weight of silicone oil

[0056] Vanillyl Nonamide 0.007 parts by weight

[0057] Kaolin 3.44 parts by weight

[0058] Methylparaben 1 part by weight

[0059] Urea 2 parts by weight

[0060] 0.5 parts by weight of ibuprofen

[0061] Isoproterenol 0.05 parts by weight

[0062] Preparation method: Weigh the raw and auxiliary materials of the prescribed amount, heat-melt and mix them under the condition of 140°C by the hot-melt method, and use them as an adhesive after stirring evenly; add the prescribed amount of ibuprofen and The isoproterenol is stirred and mixed, and prepared into a paste for patch; the paste is evenly laminated on a support body, freeze-dried, cut and packaged to obtain a finished product.

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Abstract

The invention relates to a cutaneous external patch for treating dysmenorrhea by the unified medication of a non-steroidal anti-inflammatory drug and an adrenergic receptor stimulant and a preparation method thereof. A styrene-isoprene-styrene segmented copolymer (SIS), tackifying resin, a softener and a temperature-sensitive stimulant which are used as necessary components are contained in a recipe of the preparation. According to the patch disclosed by the invention, the precipitation of crystals generated by the effective components to an adhesive layer can be effectively suppressed, and the effect of carrying out percutaneous administration by long-time stable and high-dose release is achieved; and meanwhile, the side reaction of the gastrointestinal tract can be avoided, the ice-cold stimulation is avoided, the warmth sensation is generated, the clinical compliance of a patient is enhanced, and the cutaneous external patch acts as an effective therapeutic action to the patient with the dysmenorrhea.

Description

technical field [0001] The invention mainly relates to an external skin patch for local administration, in particular to an external skin patch for treating dysmenorrhea and a preparation method thereof. Background technique [0002] Dysmenorrhea refers to pain in the lower abdomen or lower back of a woman, even reaching the lumbosacral area, before and after menstruation. It often occurs with the menstrual cycle. In severe cases, it may be accompanied by nausea and vomiting, dripping cold sweat, cold hands and feet, and even fainting, which will affect work and life. There are many reasons for dysmenorrhea, mainly due to the high content of prostaglandins in the endometrium in the secretory phase of the patient, the contraction and spasm of the uterine muscle wall, which increases the pressure in the uterus, reduces the local blood flow, and causes pain due to ischemia and hypoxia. [0003] Traditional analgesic drugs such as non-steroidal anti-inflammatory drugs have anal...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K9/70A61K45/06A61K47/32A61P15/00A61P29/02
Inventor 刘红星张扬郭映君刘莱杨娜周丽莹张伟强
Owner BEIJING TIDE PHARMA
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