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Method for preparing monodisperse molecularly imprinted polymer nano-microspheres

Active Publication Date: 2012-05-02
薛巍
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  • Abstract
  • Description
  • Claims
  • Application Information

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Problems solved by technology

[0009] The purpose of the present invention is to provide a regular microsphere with smaller particle size, more uniform dispersion and complete structure in view of the disadvantages of low drug bioavailability and obvious side effects when traditional dosage forms are applied in some special physiological environments. Preparation method of monodisperse molecularly imprinted polymer nanospheres that can significantly increase drug loading of drug microcarriers and realize slow release

Method used

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  • Method for preparing monodisperse molecularly imprinted polymer nano-microspheres
  • Method for preparing monodisperse molecularly imprinted polymer nano-microspheres
  • Method for preparing monodisperse molecularly imprinted polymer nano-microspheres

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Embodiment 1

[0025] Add the functional monomer methacrylic acid (MAA), the template gatifloxacin (GFLX) and the crosslinker ethylene glycol dimethacrylate (EGDMA) into the acetonitrile / water medium, and the total monomer feeding ratio is 2 vol %; MAA / EGDMA=1 / 5 (mol / mol); GFLX / MAA=1 / 5 (mol / mol). Add initiator azobisisobutyronitrile, in N 2 Under protection, the temperature was raised to 60°C to initiate the polymerization reaction. After 24 hours, the reaction was terminated, and after repeated centrifugation and washing and purification with methanol / acetic acid solution, microspheres with a minimum particle size of about 150 nm were obtained. The particle size and distribution of the product microspheres, and the imprinting effect are regulated by the reaction conditions ( figure 1 ).

[0026] In the in vitro loading and release experiments, the drug loading capacity of the product microspheres reached a maximum of 88.2±1.7 μg / mg, and the encapsulation efficiency reached 90.72±1.71%, w...

Embodiment 2

[0028] Add the functional monomer β-hydroxyethyl methacrylate (HEMA), the template gatifloxacin (GFLX) and the cross-linking agent ethylene glycol dimethacrylate into the acetonitrile / water medium, and the total monomer feeding Ratio 1 vol%; HEMA / EGDMA=1 / 10 (mol / mol); GFLX / HEMA =1 / 5 (mol / mol). Add initiator azobisisobutyronitrile, in N 2 Under protection, the temperature was raised to 60°C to initiate the polymerization reaction. After 24 hours, the reaction was terminated, and microspheres with a particle size of about 400 nm were obtained by centrifugation and washing and purification with methanol / acetic acid solution. The particle size and distribution of the product microspheres, and the imprinting effect are regulated by the reaction conditions ( figure 2 ).

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Abstract

The invention discloses a method for preparing monodisperse molecularly imprinted polymer nano-microspheres. The monodisperse molecularly imprinted polymer nano-microspheres are prepared by a precipitation polymerization method. The method comprises the following steps of: dispersing or dissolving a functional monomer, a crosslinking agent and template molecules in a liquid reaction medium, adding an initiator, and initiating polymerization reaction to obtain the monodisperse molecularly imprinted polymer nano-microspheres, wherein a synthetic antibacterial agent is taken as a template. In the method, the molecularly imprinted polymer nano-microspheres are prepared by uniquely combining molecular imprinting with the precipitation polymerization reaction, and the particle size and imprinting effect of a product, namely the microspheres are finely regulated and controlled by changing reaction conditions. By the method, regular microspheres which have smaller particle sizes, are uniformly dispersed and have intact structures can be prepared, the medicine loading capacity can be remarkably improved, and the sustained release can be realized; and the nano-microspheres are high in popularization and application value.

Description

[0001] technical field [0002] The invention relates to the field of controlled / sustained-release drug microcarriers, in particular to a method for preparing monodisperse molecularly imprinted polymer nanospheres. Background technique [0003] 1. Molecular imprinting technique [0004] Also known as molecular imprinting technology, it is inspired by the specific recognition function of antibodies, enzymes and some biological receptors, and prepares polymers that are completely complementary to a specific molecule (template molecule / imprinted molecule) in the three-dimensional spatial conformation and binding site. thing. Molecular imprinting technology was first used in the separation and analysis of compounds, sensors and simulated enzyme catalysis research. In recent years, researchers have used its high selective binding ability to template molecules and excellent properties such as structural stability to introduce it into the drug carrier. In the field of preparation...

Claims

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Application Information

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IPC IPC(8): C08F220/06C08F220/28C08F222/14C08J9/26A61K47/32B01J13/14B01J20/26B01J20/30
Inventor 薛巍施云峰吕红玲黄跃新谢莎莎张奕柯渔
Owner 薛巍
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