Ultrasonic process technology of tissue engineering scaffold material with controllable permeability

Abstract

The invention discloses an ultrasonic process technology of a tissue engineering scaffold material with controllable permeability. On the basis of requirements of the tissue engineering scaffold material, and aiming at the problem of toxicity of residual solvent in a chemical foaming manufacturing technology, the ultrasonic process technology comprises the following steps of: performing physical foaming on a biodegradable material by using a CO2 solid-state foaming technology so as to obtain closed-cell scaffold materials with different pore-size distributions and mechanical strengths; aiming at the problems such as poor permeability and the like of the closed-cell scaffold materials, breaking foam hole walls of the tissue engineering scaffold material through ultrasonic cavitation and micro-jet energy of pulse power ultrasounds so as to enhance connectivity of foam holes; meanwhile, adjusting the permeability of the scaffold material by adjusting the duty ratio of impulse ultrasounds during processing so as to control the degradation rate; and measuring attenuation coefficients of the scaffold material by using ultrasonic insertion in stead of a measuring technology, estimating the permeability of the material by measuring the attenuation coefficients, and guiding the selection and the control of the pulse duty factor and the ultrasonic power in the process technology.

Description

technical field [0001] The invention relates to the field of biomedical engineering and tissue engineering scaffold material processing, and is a new processing technology for controlling the permeability of tissue engineering scaffold materials by combining solid-state foaming technology and pulse power ultrasonic cavitation technology. Background technique [0002] Tissue engineering scaffold is a framework structure for cell growth, which can be implanted in organisms, effectively control and guide cells to grow in a specific direction, and can be absorbed by organisms. It needs to have moderate biodegradation rate, certain plasticity, good structure and surface compatibility. The pore structure with a certain degree of connectivity formed by the appropriate cell density and cell diameter can provide a spatial structure for cell attachment and growth and tissue metabolism, and promote tissue repair and organ function recovery. The permeability of the tissue engineering s...

AI Technical Summary

Problems solved by technology

Once fabricated, the permeability of the scaffold material cannot be changed, and the balance between the mechanical properties and permeability of the material is also difficult to control, so the fabrication process of the scaffold material is difficult to precisely control

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