Preparation method of high polymer material scaffolds for tissue engineering

A technology of polymer materials and tissue engineering, applied in stents, devices of human tubular structures, etc., can solve the problems of increased cost, unguaranteed stent integrity and mechanical properties, etc., to reduce processing energy consumption and ensure structural integrity. performance and mechanical properties, and the effect of improving fluidity
CN102501348AActive Publication Date: 2012-06-20SOUTH CHINA UNIV OF TECH
10 Cites 16 Cited by

Patent Information

Authority / Receiving Office
CN · China
Current Assignee / Owner
SOUTH CHINA UNIV OF TECH
Publication Date
2012-06-20

Smart Images

  • Figure 1
    Figure 1
  • Figure 2
    Figure 2
  • Figure 3
    Figure 3
Patent Text Reader

Abstract

The invention discloses a method for preparing high polymer material scaffolds for the tissue engineering by collaboratively adopting mixing flow field and supercritical fluid. The method comprises the following steps: (1) two or more types of high polymer material are proportionally added into an extruder or an injection molding machine for melting; (2) the blend forms a continuous phase structure under the effect of mixing flow in a machine barrel (or under the combined action of the flow field and supercritical fluid which is injected); (3) the prepared blend with the continuous phase structure is foamed through supercritical fluid; and (4) the multi-component phase in foamed blend samples is removed, and less-component phase is remained as biological scaffolds. The method of the invention collaboratively adopts chaotic mixing and supercritical fluid to prepare the blend with the continuous phase structure in the condition that the less-component phase content is low, and enables the blend to be applied to the preparation of biological scaffolds for the tissue engineering. Moreover, the method has fewer processes, can realize batch production, and is easy to promote during the industrial production.
Need to check novelty before this filing date? Find Prior Art

Description

technical field

[0001] The invention relates to a technology for preparing a polymer material bracket for tissue engineering, in particular to a method for preparing a polymer material bracket for tissue engineering by using a mixing flow field and a supercritical fluid. Background technique

[0002] The basic principle and method of tissue engineering is to plant functional cells cultured in vitro on a scaffold with good biocompatibility and absorption by the body to form a complex, and then implant the complex into the body's tissues and organ lesions parts, in order to achieve the purpose of repair and reconstruction. In tissue engineering, scaffolds play a key role, not only providing structural support for specific cells, but also serving as templates to guide tissue regeneration and control tissue architecture. Therefore, in addition to the need to select materials with better biocompatibility to prepare the scaffold, the most important thing is to make the scaffold h...

Claims

the structure of the environmentally friendly knitted fabric provided by the present invention; figure 2 Flow chart of the yarn wrapping machine for environmentally friendly knitted fabrics and storage devices; image 3 Is the parameter map of the yarn covering machine
Login to View More