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Preparation method of high polymer material scaffolds for tissue engineering

A technology of polymer materials and tissue engineering, applied in the direction of scaffolds, devices of human tubular structures, etc., can solve the problems of increased cost, integrity and mechanical properties of scaffolds, etc., to reduce processing energy consumption and ensure structural integrity Sexuality and mechanical properties, the effect of fewer processes

Active Publication Date: 2014-06-11
SOUTH CHINA UNIV OF TECH
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

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Problems solved by technology

For higher-cost materials, this will undoubtedly increase the cost; if its content is reduced, the continuity of the co-continuous phase structure will be reduced, so that the integrity and mechanical properties of the entire scaffold will not be guaranteed

Method used

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  • Preparation method of high polymer material scaffolds for tissue engineering
  • Preparation method of high polymer material scaffolds for tissue engineering
  • Preparation method of high polymer material scaffolds for tissue engineering

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0046] figure 1 The specific implementation process of the method of the present invention is shown. Such as figure 1 As shown, the equipment required for the implementation of the method of the present invention includes an extruder or injection molding machine A, a supercritical fluid forming and delivery system 6 , an autoclave 7 and a leaching device 10 . Supercritical fluid formation and delivery system 6 is connected with extruder or injection molding machine barrel 5; injection molding machine or extruder barrel 5 is connected with mold 8 or machine head 9; autoclave 7 is connected with supercritical fluid formation and delivery The system 6 is connected, the structure of the screw rod 3 can be changed, and the outer wall of the barrel 5 is equipped with a heating ring (not shown in the figure).

[0047] The whole process of the mixing flow field and supercritical fluid cooperating to prepare the polymer material scaffold for tissue engineering is as follows: start ...

Embodiment 2

[0050] (1) Weigh 70 parts of polylactic acid (PLA) and 30 parts of low-density polyethylene (HDPE) by mass, and mix them evenly.

[0051] (2) Add the blend in step (1) into a single-screw extruder, and prepare a PLA / HDPE blend by means of chaotic mixing.

[0052] Figure 4 Shown are scanning electron micrographs of the prepared PLA / HDPE blends. It can be seen from the figure that when the content of HDPE is 30%, the blend forms a good co-continuous phase structure.

Embodiment 3

[0054] (1) Two biodegradable materials, 65 parts of starch acetate (AS) and 35 parts of PLA, were weighed by mass and mixed evenly.

[0055] (2) Add the blend in step (1) into the extruder, and prepare the AS / PLA blend by means of chaotic mixing.

[0056] Figure 5 Shown are scanning electron micrographs of the as-prepared AS / PLA blends. It can be seen from the figure that the blend forms a co-continuous phase structure at a PLA content of 35%.

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Abstract

The invention discloses a method for preparing high polymer material scaffolds for the tissue engineering by collaboratively adopting mixing flow field and supercritical fluid. The method comprises the following steps: (1) two or more types of high polymer material are proportionally added into an extruder or an injection molding machine for melting; (2) the blend forms a continuous phase structure under the effect of mixing flow in a machine barrel (or under the combined action of the flow field and supercritical fluid which is injected); (3) the prepared blend with the continuous phase structure is foamed through supercritical fluid; and (4) the multi-component phase in foamed blend samples is removed, and less-component phase is remained as biological scaffolds. The method of the invention collaboratively adopts chaotic mixing and supercritical fluid to prepare the blend with the continuous phase structure in the condition that the less-component phase content is low, and enables the blend to be applied to the preparation of biological scaffolds for the tissue engineering. Moreover, the method has fewer processes, can realize batch production, and is easy to promote during the industrial production.

Description

technical field [0001] The invention relates to a technology for preparing a polymer material bracket for tissue engineering, in particular to a method for preparing a polymer material bracket for tissue engineering by using a mixing flow field and a supercritical fluid. Background technique [0002] The basic principle and method of tissue engineering is to plant functional cells cultured in vitro on a scaffold with good biocompatibility and absorption by the body to form a complex, and then implant the complex into the body's tissues and organ lesions parts, in order to achieve the purpose of repair and reconstruction. In tissue engineering, scaffolds play a key role, not only providing structural support for specific cells, but also serving as templates to guide tissue regeneration and control tissue architecture. Therefore, in addition to the need to select materials with better biocompatibility to prepare the scaffold, the most important thing is to make the scaffold h...

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): B29C44/38C08L67/02C08L71/02C08J9/12A61F2/04A61F2/82
Inventor 黄汉雄黎珂
Owner SOUTH CHINA UNIV OF TECH
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