Endothelialization system for surface of induction degradable blood vessel stent

Abstract

The invention discloses an endothelialization system for the surface of an induction degradable blood vessel stent. The system comprises a degradable magnetic material blood vessel stent, magnetic nano targeting grains and an external magnetic field; the degradable magnetic material blood vessel stent is implanted into a human body in a non-magnetic manner; the magnetic nano targeting grains can be in specificity combination so as to be used for cells for repairing endodermis and have magnetic response; and the external magnetic field is controllable in strength and is used for leading the degradable magnetic material blood vessel stent to magnetize outside the human body so as to generate a high magnetic field. In the technical scheme, after the degradable magnetic material blood vessel stent is implanted in the human body, magnetization is realized under the effect of the external magnetic field so as to generate the high magnetic field, the cells which are combined with the magnetic nano targeting grains and used for repairing the endodermis are attracted to the surface of the stent, fast endothelialization of an implanted portion of the stent is realized, targeting property of the magnetic nano targeting grains is good, application quantity is controller, and the magnetic blood vessel stent can be degraded gradually and disappears finally. The endothelialization system is applicable to patients with coronary heart disease, and simultaneously has reference significance for diseases of cancer, tumor and the like.

Description

technical field [0001] The invention belongs to the field of biomedical materials and nano-biotechnology, and in particular relates to an endothelialization system for induced degradable vascular stent surface. Background technique [0002] Coronary heart disease is a frequent cardiovascular disease. The number of patients with coronary heart disease in my country is increasing at a rate of 2-4 million per year, which seriously threatens people's health and safety. The primary cause of coronary heart disease is the lesions of vascular endothelial cells, which lead to the gradual formation of plaques in the blood vessels, that is, atherosclerosis, which indicates that patients will enter the middle and late stages of coronary heart disease; plaques not only cause blood flow disorders, but also block blood vessels in severe cases and cause sudden death of patients . [0003] So far, patients with coronary heart disease are mainly treated with drug-eluting vascular stents. Alt...

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Problems solved by technology

However, there are still many problems at present. 1) As a long-term use of iron in the body, the mechanical properties are slightly insufficient, and the elastic retraction is serious; 2) The degradation rate is uncontrollable, and the degradation makes the surface unable to be fixed for biocompatibility improvement. 3) The biocompatibility needs to be improved urgently; 4) The nickel or cobalt added to the iron alloy currently used for magnetization is an element harmful to the human body, which may cause hemangioma; 5) Human organs are exposed to high magnetic fields for a long time, and the drop organic disease causing

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