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Compound tetracaine composition as well as preparation method and application thereof

A technology of compound Dingka and composition, which is applied in the direction of drug combination, effective ingredients of hydroxyl compounds, and pharmaceutical formulas, etc., to achieve the effects of convenient use, promotion of wound healing, and remarkable effect

Active Publication Date: 2012-07-18
BEIJING RECTUM HOSPITAL
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

At present, it has not been used as the main component of pharmaceutical compositions or preparations for treating anal fissures and relieving anal pain

Method used

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  • Compound tetracaine composition as well as preparation method and application thereof
  • Compound tetracaine composition as well as preparation method and application thereof
  • Compound tetracaine composition as well as preparation method and application thereof

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0039] Embodiment 1: ointment

[0040] 1. Prescription: In each g ointment, tetracaine hydrochloride 3.0mg, ephedrine hydrochloride 3.1mg, phenobarbital 3.0mg, diphenhydramine hydrochloride 1.6mg, hydrocortisone 0.7mg, borneol 8.0mg, mint oil 3ml (density: 0.888-0.908g / ml), add yellow petrolatum to 1000g, and prepare 1000g ointment. The ointment prepared in this example has the best anti-inflammatory and analgesic effects.

[0041] 2. Preparation method: After mixing the coarse powder raw materials of tetracaine hydrochloride, ephedrine hydrochloride, phenobarbital, diphenhydramine hydrochloride, hydrocortisone, and borneol according to the method of increasing the dosage in this embodiment , dried and pulverized into fine powder for later use; melt yellow vaseline at 50° C., and add it to the pulverized fine powder according to this embodiment. Add peppermint oil during stirring, and mix until semi-solidified.

Embodiment 2

[0042] Embodiment 2: ointment

[0043] 1. Prescription: In each g ointment, tetracaine hydrochloride 3.3mg, ephedrine hydrochloride 2.8mg, phenobarbital 3.3mg, diphenhydramine hydrochloride 1.4mg, hydrocortisone 0.9mg, borneol 6.0mg, mint oil 3.5ml (density: 0.888-0.908g / ml), add white petrolatum to 1000g, and prepare 1000g ointment.

[0044] 2. Preparation method: After mixing the coarse powder raw materials of tetracaine hydrochloride, ephedrine hydrochloride, phenobarbital, diphenhydramine hydrochloride, hydrocortisone, and borneol according to the method of increasing the dosage in this embodiment , dried and pulverized into fine powder for later use; melt white vaseline at 60° C., and add it to the above pulverized fine powder according to the proportion of this embodiment. Add peppermint oil during stirring, and mix until semi-solidified.

Embodiment 3

[0045] Embodiment 3: ointment

[0046] 1. Prescription: In each g ointment, tetracaine hydrochloride 2.7mg, ephedrine hydrochloride 3.4mg, phenobarbital 2.7mg, diphenhydramine hydrochloride 1.8mg, hydrocortisone 0.5mg, borneol 1.0mg, mint oil 3.2ml (density: 0.888-0.908g / ml), add yellow petrolatum to 1000g, and prepare 1000g ointment.

[0047] 2. Preparation method: After mixing the coarse powder raw materials of tetracaine hydrochloride, ephedrine hydrochloride, phenobarbital, diphenhydramine hydrochloride, hydrocortisone, and borneol according to the method of increasing the dosage in this embodiment , dried and pulverized into fine powder for later use; melt yellow vaseline at 55° C., and add it to the pulverized fine powder according to this embodiment, and adjust the mixer at a speed of 200 for uniform stirring in the molten state Add peppermint oil during stirring, and mix until semi-solidified.

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Abstract

The invention relates to a compound tetracaine composition as well as a preparation method and application thereof. The composition comprises the following raw medicines: tetracaine, ephedrine, phenobarbital, diphenhydramine, hydrocortisone and borneol. The compound tetracaine composition has the effects of removing necrotic tissue and promoting granulation, clearing heat and relieving pain, diminishing inflammation and resisting infection and promoting wound healing and has obvious curative effects of treating acute-stage anal fissure and acute attack of chronic anal fissure. When the compound tetracaine composition is matched with an anus suppository to perform non-surgical treatment of piles, the curative effects of the compound tetracaine composition on relieving bleeding, pain and abjection symptoms of piles are obvious. As a whole, the compound tetracaine composition has the advantages of obvious curative effect and the like, is quick to act, is convenient to use and is safe; and when the compound tetracaine composition is used, a patient does not feel pain; and effective rate reaches 100%.

Description

technical field [0001] The invention relates to a compound pharmaceutical composition, in particular to a compound tetracaine composition, and other preparation methods and applications. Background technique [0002] Tetracaine, also known as dicaine, pantocaine, tetracaine. Its hydrochloride is commonly used as white crystal or crystalline powder. It has local anesthetic effect and is mainly used for mucosal anesthesia. The effect is rapid, and it takes effect within 1 to 3 minutes. Keep it for 2-3 hours. Ophthalmology use 0.5% ~ 1% solution, no serious adverse reactions such as corneal damage. 1% to 2% solution for nose and throat department, the total amount should not exceed 20ml. When applying, 1 drop of 0.1% epinephrine hydrochloride solution should be added to every 3ml. Use 0.025% to 0.03% solution for infiltration anesthesia, and 0.1% to 0.3% solution for nerve conduction block. Spinal anesthesia with 10 ~ 15mg mixed with cerebrospinal fluid and injected. 0....

Claims

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Application Information

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IPC IPC(8): A61K31/573A61P1/00A61P29/00A61P9/14A61K31/515A61K31/245A61K31/137A61K31/045A61K31/135
Inventor 白蕊卢克捷朱钢张秀王维平孙冰
Owner BEIJING RECTUM HOSPITAL
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