Hot melt pressure-sensitive adhesive and preparation method thereof

A technology of hot-melt pressure-sensitive adhesive and isoprene, which is applied in the direction of pharmaceutical formulations, medical preparations of non-active ingredients, sheet-like delivery, etc. problem, achieve the effect of maintaining thermal stability and improving drug release performance

Inactive Publication Date: 2012-07-18
DALIAN UNIV OF TECH
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

However, the traditional SIS hot-melt pressure-sensitive adhesive is hydrophobic, which is not conducive to the release of hydrophilic drugs, and a considerable amount of drugs are hydrophilic drugs. Therefore, the current SIS hot-melt pressure-sensitive adhesive matrix cannot meet the requirements of hydrophilic drugs. Requirements for Transdermal Administration of Sexual Drugs
Chinese patent 200410015623.2 discloses a thermoplastic elastomer-based hot-melt pressure-sensitive adh...

Method used

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  • Hot melt pressure-sensitive adhesive and preparation method thereof
  • Hot melt pressure-sensitive adhesive and preparation method thereof
  • Hot melt pressure-sensitive adhesive and preparation method thereof

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0038] 130℃, filled with N 2 In a self-made airtight container, add 50 parts by weight of SiS, 1.5 parts by weight of N, zinc N-dibutylaminodithiocarbamate, 40 parts by weight of mineral oil with 10% epoxy degree successively, and the materials are all in about 15 minutes Melting; then adding 90 parts by weight of petroleum resin, about 30 minutes to complete melting; heating to 180 ° C, rotating speed 500r / min, mechanical stirring for 30 minutes, to obtain a uniformly mixed SIS single-phase hot melt adhesive.

[0039] At 160-180°C, filled with N 2 In a self-made airtight container, the SIS single-phase hot melt adhesive prepared above is mixed with 60 parts by weight of the drug release modifier methyl methacrylate / trimethylaminoethyl methacrylate chloride, N 2protection, rotating speed 500r / min, and mechanical stirring for 30 minutes to obtain a uniformly mixed two-phase hot-melt pressure-sensitive adhesive.

[0040] Mix and dissolve 6 parts by weight of luteolin and 6 par...

Embodiment 2

[0042] 130℃, filled with N 2 In the self-made airtight container, add 50 parts by weight of SIS, 1.5 parts by weight N of epoxy degree of 10% successively, zinc N-dibutylcarbamate, 40 parts by weight of mineral oil, all materials in about 15min Melting; then adding 90 parts by weight of petroleum resin, about 30 minutes to complete melting; heating to 180 ° C, rotating speed 500r / min, mechanical stirring for 30 minutes, to obtain a uniformly mixed SIS single-phase hot melt adhesive.

[0043] At 160-180°C, filled with N 2 In a self-made airtight container, the SIS single-phase hot melt adhesive prepared above is mixed with 60 parts by weight of the drug release modifier methyl methacrylate / trimethylaminoethyl methacrylate chloride, N 2 protection, rotating speed 500r / min, and mechanical stirring for 30 minutes to obtain a uniformly mixed two-phase hot-melt pressure-sensitive adhesive.

[0044] 6 parts by weight of baicalin and 6 parts by weight of propylene glycol are mixed a...

Embodiment 3

[0046] 130℃, filled with N 2 In the self-made airtight container of 50 parts by weight graft rate 5% maleic anhydride graft SIS, 1.5 parts by weight N, N-dibutylcarbamate zinc, 40 parts by weight mineral oil successively , the material is completely melted in about 15 minutes; then 90 parts by weight of petroleum resin is added, and it is completely melted for about 30 minutes; the temperature is raised to 180°C, the speed is 500r / min, and the mechanical stirring is carried out for 30 minutes to obtain a uniformly mixed SIS single-phase hot melt adhesive.

[0047] At 160-180°C, filled with N 2 In a self-made airtight container, the SIS single-phase hot melt adhesive prepared above is mixed with 60 parts by weight of the drug release modifier methyl methacrylate / trimethylaminoethyl methacrylate chloride, N 2 protection, rotating speed 500r / min, and mechanical stirring for 30 minutes to obtain a uniformly mixed two-phase hot-melt pressure-sensitive adhesive.

[0048] Mix and d...

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PUM

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Abstract

The invention relates to a hot melt pressure-sensitive adhesive suitable for percutaneous administration of hydrophilic medicines, and a preparation method of the hot melt pressure-sensitive adhesive, belonging to the technical field of the hot melt pressure-sensitive adhesive. The hot melt pressure-sensitive adhesive is prepared by introducing polar groups into the molecules of styrene-isoprene-styrene thermoplastic elastomer and adding a hydrophilic medicine release regulator, so that the characteristic of lipotropy of the traditional styrene-isoprene-styrene hot melt pressure-sensitive adhesive matrix can be changed. According to the invention, the release action of the hydrophilic medicine in the styrene-isoprene-styrene hot melt pressure-sensitive adhesive matrix can be obviously improved.

Description

technical field [0001] The invention belongs to the technical field of hot-melt pressure-sensitive adhesives, and relates to a styrene-isoprene-styrene elastomer (SIS)-based hot-melt pressure-sensitive adhesive suitable for transdermal administration of hydrophilic drugs and a preparation method. Background technique [0002] The transdermal drug delivery system refers to the way of drug delivery through skin application. The drug diffuses through the skin through the stratum corneum, and is absorbed by the capillary into the blood circulation of the whole body, so as to realize the treatment and prevention of diseases. The drug delivery system has the advantages that oral administration, injection and other administration methods do not have: the drug can avoid the influence of the "first-pass effect" of the liver and gastrointestinal tract, and the utilization rate is high; the blood drug concentration is constant, and there is no "peak-valley phenomenon", The toxicity and...

Claims

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Application Information

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IPC IPC(8): A61K47/32A61K47/44A61K9/70
Inventor 赵忠夫王永朝方兵
Owner DALIAN UNIV OF TECH
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