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Bacteriostatic, hygroscopic and calcium ion-contributing wound dressings

A wound dressing, calcium ion technology, applied in absorbent pads, textiles and papermaking, medical science and other directions, can solve the problem of using the same wound, unrealized dressings, etc., to achieve good hygroscopicity and outstanding bacteriostatic effect.

Active Publication Date: 2018-07-13
FOSHAN UNITED MEDICAL TECH +1
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

However, the inventor has noticed that so far, the wound dressings of the prior art are usually formed by two kinds of fibers at the same time, and the dressing formed by the above three kinds of fibers has not been realized to be used on the same wound at the same time

Method used

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  • Bacteriostatic, hygroscopic and calcium ion-contributing wound dressings
  • Bacteriostatic, hygroscopic and calcium ion-contributing wound dressings
  • Bacteriostatic, hygroscopic and calcium ion-contributing wound dressings

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0045] Preparation of wound dressings containing 10% calcium alginate, 80% modified cellulose and 10% modified chitosan:

[0046] Raw material: calcium alginate fiber, fineness 7.0dtex, length 45 mm, solution A absorption rate above 1400%;

[0047] Modified cellulose with a fineness of 1.7 dtex and a length of 65 mm. The fiber is treated with carboxymethyl, and its hygroscopicity is in the fiber state. It contains 8.298 grams of sodium chloride and 0.368 grams of calcium chloride dihydrate per liter. The absorption rate of the solution (A solution) is above 1500%;

[0048] Modified chitosan, the fineness is 2.0dtex, the length is 50 mm, the fiber is processed by acylation, and its hygroscopicity is 8.298 grams of sodium chloride and 0.368 grams of calcium chloride dihydrate per liter in fiber state The absorption rate of the solution (A solution) is above 200%;

[0049] 7 grams of calcium alginate fiber, 56 grams of modified cellulose and 7 grams of modified chitosan are mix...

Embodiment 2

[0053] In order to observe the antibacterial performance of the dressing obtained in Example 1, Bacillus subtilis with an inoculation amount of about 250 μL×10E6 cfu / mL was evenly spread in a petri dish, and then the dressing obtained in Example 1 was cut into 2×2 cm and put in it , continuously cultured at a constant temperature of 37°C and observed the growth of bacteria on each plate.

[0054] figure 1 The antibacterial zone of the dressing after 2 days, 3 days, and 8 days in the Bacillus subtilis petri dish is shown, and it can be seen that the bacteriostatic effect is still maintained on the 8th day.

Embodiment 3

[0056] In order to observe the calcium release performance of the wound dressing obtained in Example 1, 10 mL of 0.9% NaCl solution was added to the test tube, then the dressing obtained in Example 1 was cut into 2.5 × 2.5 cm, weighed and put into it, parallel at 37 ° C Design simulation experiments from 1 day to 7 days. The release properties are obtained from the calcium content in the dressing and the calcium content in the release solution, e.g. figure 2 As shown, the release ability and time change of calcium ions, wherein the total release ratio is the ratio of the total amount of calcium in the release liquid to the calcium content in the fiber. Detected by atomic absorption spectrophotometer, the total release ratio of calcium was 26.9% on average, and the average release rate was 21.7ppm / 0.1g fiber / 10mL saline. The content of calcium alginate as a calcium source in the blend is low, and the calcium release rate is also low.

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Abstract

The invention relates to a wound dressing with bacteriostasis, moisture absorption and calcium ion contribution. The wound dressing comprises chitosan fiber, calcium alginate fiber and chemically modified cellulose fiber. The invention also relates to the preparation of the wound dressing and the use of the wound dressing in chronic wounds such as venous stasis ulcers, pressure ulcers and diabetic foot ulcers and other chronic ulcers.

Description

technical field [0001] The present invention relates to a wound dressing comprising chitosan fibers, calcium alginate fibers and chemically modified cellulose fibers. In particular, the present invention relates to a wound dressing, which is made of chitosan fiber, chemically modified cellulose fiber and seaweed fiber, and combines the advantages of the three fibers on wound healing. The present invention also relates to the use of wound dressings for chronic wounds such as venous stasis ulcers, pressure ulcers and diabetic foot ulcers and other chronic ulcers. Background technique [0002] It is well known that when choosing a wound dressing to treat a wound, one of the challenges that caregivers face is managing chronic wound exudate while providing a favorable environment for wound healing, including, but not limited to, inhibiting microbial growth And can provide calcium ions. [0003] Chitosan fiber has antibacterial effect, among which the NH of chitosan 2 The posit...

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): A61L15/28
CPCA61L15/28A61F2013/0054A61F2013/00744A61L15/46D04H1/46
Inventor 王晓东张大伟史福军
Owner FOSHAN UNITED MEDICAL TECH
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