Application of beautifying cornea lens

A cosmetic and corneal technology, applied in the application field of cosmetic corneal lenses, can solve the problems of accelerating cataracts, affecting safety, poor tolerance and compliance, etc., to repair corneal tissue defects, strengthen mechanical strength, and improve ocular surface. effect of appearance

Inactive Publication Date: 2012-07-25
ZHONGSHAN OPHTHALMIC CENT SUN YAT SEN UNIV
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

However, the poor tolerance and compliance of contact lenses, and the dyeing agents selected for dyeing, whether metallic or non-metallic, have problems to varying degrees: fading of coloring, poor controllability of dyeing range and color depth , inflammatory response, and the safety of the dye is affected by its poor biocompatibility or pote...

Method used

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Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0019] The purpose of this embodiment is to use cosmetic corneal lenses for corneal surface lens surgery to repair corneal tissue defects and improve the appearance of the ocular surface.

[0020] Cosmetic corneal lens preparation method: add decellularized porcine corneal stroma to 0.5% (mass volume concentration) genipin aqueous solution (pH value is 7.0), vibrate in a water bath at 20 ° C for 8 hours, rinse and freeze-dry to prepare Get tan cosmetic corneal lenses. The lens is brown, with a thickness of 0.1 to 0.4 mm and a circular shape (the specific shape and specifications depend on the case).

[0021] According to the requirements of corneal surface lens surgery, an inlay groove is made on the surface of the cornea, and the thin peripheral edge of the brown cosmetic corneal lens is inserted into the groove, fixed with sutures or biological glue, and the treated eye is bandaged under pressure. According to the routine treatment of corneal surface lens after operation. ...

Embodiment 2

[0023] The purpose of this embodiment is to use the cosmetic corneal lens for interlayer corneal implantation to treat photophobia, glare, diplopia and other visual adverse symptoms caused by abnormal iris.

[0024] Cosmetic corneal lens preparation method: adding collagen corneal shield to 2% (mass volume concentration) genipin alcohol solution (pH value is 9.0), shaking in a water bath at 56°C for 1 hour, rinsing and freeze-drying to prepare Black cosmetic corneal lens, the color of the cosmetic corneal lens is black, the thickness is 0.1mm, and the ring shape (the specific shape and specification depends on the case).

[0025] It is used to treat photophobia, glare, and diplopia caused by iris abnormalities such as aniridia, iris defects caused by various reasons, and diplopia after iridotomy. Make a pouch between the corneal stroma, implant a black cosmetic corneal lens into the corneal stroma, fix it, and bandage the operated eye with pressure. Routine treatment after in...

Embodiment 3

[0027] The purpose of this embodiment is to use the cosmetic corneal lens as an ocular surface mask to protect the cornea in ophthalmic surgery.

[0028] Cosmetic corneal lens preparation method: add freeze-dried decellularized rabbit corneal stroma to 0.01% (mass volume concentration) genipin aqueous solution (pH value is 4.0), shake in a 37°C water bath for half an hour, rinse and freeze The white cosmetic corneal lens is prepared by drying, and the cosmetic corneal lens is white in color, has a thickness of 0.5 mm, and is circular in diameter of 5-10 mm.

[0029] Used as an ocular surface mask to protect the cornea in orbital surgery, eyelid surgery, eye muscle surgery, conjunctival surgery, and glaucoma surgery. Place white cosmetic corneal lenses on the surface of the cornea after immersing them in saline for 5 minutes. As a biomaterial, it can keep the ocular surface moist and protected, and at the same time protect the macula from surgery-induced photostimulation damag...

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Abstract

The invention discloses application of a beautifying cornea lens, and aims at applying the beautifying cornea lens to repairing the damage of cornea tissues, improving the appearance of an ocular surface, curing visual symptoms such as photophoby, glaring, diplopia and the like resulting from iris abnormity, or being used as a covering sheet or a medicine carrier for protecting the cornea in an ophthalmic operation, wherein the beautifying cornea lens is prepared in a way that: a biological material rich in amino is added into a solution containing genipin or genipin derivatives, the genipin is taken as a cross-linking agent to conduct the contact reaction, and then the mixture is rinsed, frozen and dried to prepare the beautifying cornea lens. The beautifying cornea lens provided by the invention can be used for repairing the damage of the cornea tissues, improving the appearance of the ocular surface, curing the visual symptoms such as photophoby, glaring, diplopia and the like resulting from iris abnormity, or being used as the covering sheet or the medicine carrier for protecting the cornea in the ophthalmic operation, therefore, a new approach is directly explored for clinical application.

Description

Technical field: [0001] The invention belongs to the field of medicine, and in particular relates to the application of cosmetic corneal lenses. Background technique: [0002] Currently, there are limited effective treatments for patients with blindness due to severe impairment of visual function due to various reasons, and patients with corneal diseases, defects, scars, or leukocoria. For blind patients with corneal scars, some scholars try to use contact lenses and corneal dyeing to improve their appearance. However, the poor tolerance and compliance of contact lenses, and the dyeing agents selected for dyeing, whether metallic or non-metallic, have problems to varying degrees: fading of coloring, poor controllability of dyeing range and color depth , inflammatory response, and the poor biocompatibility or potential toxicity of the dye affects its safety, thus limiting its clinical application. For blind patients with corneal diseases or defects, the treatment is only to...

Claims

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Application Information

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IPC IPC(8): A61F2/14A61F9/007A61L31/00A61L31/14
Inventor 王智崇全大萍刘钊周强
Owner ZHONGSHAN OPHTHALMIC CENT SUN YAT SEN UNIV
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