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Capillary surface plasmon resonance sensor

A surface plasmon and resonant sensor technology, which is applied in the direction of instruments, scientific instruments, measuring devices, etc., can solve the problems that the system cannot be miniaturized, and achieve the effect of miniaturized structure, low cost, convenient and reliable use

Inactive Publication Date: 2012-07-25
ZHEJIANG UNIV
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

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Problems solved by technology

[0008] At present, the SPR sensor is developing towards the direction of miniaturization of the structure, and the prism-coupled SPR sensor cannot be miniaturized due to factors such as flow cells and other peripheral components.

Method used

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Embodiment Construction

[0026] A capillary surface plasmon resonance sensor such as figure 1 As shown, it includes LED light source 1 , collimating lens 2 , telescopic system, polarizer 5 , capillary 6 and CCD detector 7 arranged sequentially along the optical path, wherein the telescopic system consists of positive lens 3 and negative lens 4 .

[0027] Such as figure 2 As shown, the shape and structure of the capillary 6 is a hollow cylindrical tube, which plays the role of a flow cell during the use of the sensor. The film material is calcium fluoride, and the thickness is 1 / 4 times the wavelength of the light source. Since the light source wavelength is 632.8nm, the thickness of the antireflection film is 158.2nm. The parallel light is refracted after being incident on the surface of the outer wall of the capillary 6 at a suitable position, so that the incident light at different angles within the required range can be obtained conveniently. The surface of the inner wall of the capillary 6 is c...

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Abstract

The invention discloses a capillary surface plasmon resonance sensor, which comprises an LED (light emitting diode) light source, a collimating lens, a telescopic system, a polarizing film, a capillary to double as a flow cell, and a CCD (charge coupled device) detector; an anti-reflection film is plated at the outer surface of the capillary, and a metal thin film is plated at the inner surface; and the polarized light obtained by the polarizing film is refracted into the capillary by the anti-reflection film arranged at the outer surface of the capillary, and then reflected into the CCD detector by the metal thin film arranged at the inner surface of the capillary. According to the capillary surface plasmon resonance sensor provided by the invention, the conversion of beam pattern and the excitation of SPR (surface plasma resonance) are achieved by the capillary plated with the metal thin film at the inner surface thereof, the traditional prism coupling mode is replaced, the capillary is synchronously to double as the flow cell, and namely the sensor is integrated with the flow cell; and in this way, the structure of the sensor system is smaller, the cost is lower, and the use is more convenient and more reliable.

Description

technical field [0001] The invention relates to a capillary surface plasmon resonance sensor, which belongs to the technical field of analysis and measurement control. Background technique [0002] Surface plasmon resonance (SPR) sensing technology is a highly sensitive detection technology, widely used in the study of binding specificity, antibody selection, antibody quality control, disease mechanism, drug discovery, biotherapy, bioprocessing, biological Markers, ligand fishing, gene regulation, cell signaling, affinity chromatography, structure-function relationships, small molecule interactions, etc. [0003] Metal thin film SPR is a kind of evanescent wave generated when p-polarized light is totally reflected at the interface between glass and metal thin film, which triggers free electrons on the metal surface to generate surface plasmons. a resonance phenomenon. At resonance, the incident light is absorbed, the energy of the reflected light drops sharply, and the ref...

Claims

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Application Information

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IPC IPC(8): G01N21/55G01N21/552
Inventor 王晓萍詹舒越
Owner ZHEJIANG UNIV
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