Efficient production technology of nicotinamide

Abstract

The invention discloses an efficient production technology of nicotinamide. The efficient production technology of nicotinamide is carried out in the following steps: dissolving 0.48mol of 3-cyanopyridine in 5.55mol of water, and adding 0.11mol of a bimetallic oxide manganese-Z catalyst, making the mixture reflux for 3h at a temperature of 100DEG C under stirring, filtering the reaction solution to remove the catalyst, concentrating the filtrate and conducting drying, thus obtaining solid nicotinamide. Preparation of the bimetallic oxide manganese-Z catalyst takes manganese sulfate, metal Z sulfate, a sodium hydroxide aqueous solution and a hydrogen peroxide aqueous solution as raw materials, which are subjected to the steps of alkalization, oxidation, washing, activation and dehydration. The method of the invention no longer uses liquefied ammonia as a catalyst protective agent, thus effectively protecting the ecological environment.

Description

technical field [0001] The invention relates to the field of production of B vitamins, and more specifically relates to a new production process of nicotinamide. Background technique [0002] Niacinamide is an indispensable B vitamin for human and animal bodies, and an important component of coenzymes. It participates in the redox process, has the function of promoting cell metabolism and dilating blood vessels, and can promote the growth and development of human and animal bodies. It has a significant effect on the prevention and treatment of pellagra, arteriosclerosis, and cerebral thrombosis. At present, nicotinamide is mainly produced by chemical method and microbial method at home and abroad. At present, the domestic production of nicotinamide by chemical method mainly adopts 3-cyanopyridine alkaline hydration method. This method adopts the process route of producing nicotinamide with 3-cyanopyridine as raw material, manganese dioxide as catalyst, and liquid ammonia ...

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Problems solved by technology

There is a big impact on the export of products

[0005] 2. The melting distance of the product is between 128.5-130.5°C, and a large melting distance indicates that the purity is not good

[0006] 3. The activity of the catalyst decreases rapidly, and the consumption of the catalyst is relatively large, resulting in a large amount of solid waste, which has a certain impact on the environment and increases the production cost

[0007] 4. For every ton of nicotinamide produced, 100kg of liquid ammonia is discharged as waste, which does not comply with the national policy of energy conservation and emission reduction, causing great pollution to the ecology and production environment, and increasing production costs

[0008] 5. Due to the need to use a large amount of liquid ammonia in production, it brings many hidden dangers to safe production

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