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Method for preparing total matrines

A technology for total alkaloids and Radix Sophorae Radix, applied in the field of preparation of total alkaloids Sophorae Radix, can solve problems such as high cost, pollute the environment, lack of practicability, etc., and achieve the effects of low production cost and simple process

Inactive Publication Date: 2012-08-15
NINGXIA BAUHINIA PHARMA
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  • Abstract
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Problems solved by technology

[0003] The total alkaloids of Sophora flavescens has high medicinal value, and its industrial preparation method is not much reported in the patent literature, and the purity and color of the total alkaloids of Sophora flavescens prepared can not meet the standard, such as CN1594317C, the publication date is March 2005 On the 16th, it was pointed out that there were only four effective methods for preparing total alkaloids of Sophora flavescens at that time, the water-alcohol method, the lime-sulfur-alcohol method, the ammonia-chloroform method and the resin method. Not only the purity can only reach 70%, but only yellow or yellow The brown solid total alkaloids of matrine, more importantly, are costly, pollute the environment, and endanger the health of workers, so they are not practical

Method used

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  • Method for preparing total matrines

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Effect test

Embodiment 1

[0026] (1) Crushing: crush the selected Sophora flavescens root medicinal material into coarse powder, moisten it for later use;

[0027] (2) Extraction: Put the wetted coarse powder into a continuous countercurrent extraction unit, and the temperature is controlled at 80~95℃ for continuous countercurrent drinking water extraction;

[0028] (3) Concentration: The extract is pumped into a double-effect concentrated ointment tank for concentration;

[0029] (4) One-time extraction and neutralization: add caustic soda into the concentrated solution, adjust the pH value to 11-12, add toluene for extraction, until there is no or a very small amount of alkaloids in the concentrated solution to dehydrate; Add 10% hydrochloric acid to neutralize, until the pH of the first neutralization solution is 4~5;

[0030] (5) Secondary extraction and neutralization: Add caustic soda in the primary neutralization solution, adjust the pH to 11-12, and add toluene for extraction until there are no or very...

Embodiment 2

[0035] (1) Crushing: crush the selected Sophora flavescens root medicinal material into coarse powder, moisten it for later use;

[0036] (2) Extraction: Put the wetted coarse powder into the continuous countercurrent extraction unit, and the temperature is controlled at 80~95℃ for drinking water extraction;

[0037] (3) Concentration: The extract is pumped into a double-effect concentrated ointment tank for concentration;

[0038] (4) One-time extraction and neutralization: add solid sodium hydroxide to the concentrate to adjust the PH value to 11-12, add benzene for extraction, until there is no or a very small amount of alkaloids in the concentrate to dehydrate; add 10 % Hydrochloric acid neutralize until the pH of the neutralization solution is 4;

[0039] (5) Secondary extraction and neutralization: Add solid sodium hydroxide to the primary neutralization solution to adjust the pH to 11, add benzene for extraction, until there is no or a very small amount of alkaloids in the conc...

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Abstract

The invention provides a method for preparing total matrines. The method comprises the steps of grinding, extracting, concentrating, extracting and the like. The method adopting continuous countercurrent water extraction has the following advantages: the products not only have low production cost and simple process and are suitable for industrial mass production but also do not have organic solvent residues and have content as high as 80% in terms of oxymatrine; and the purity is hard to reach by other processes.

Description

Technical field [0001] The invention relates to a preparation method of total alkaloids of matrine. Background technique [0002] The Chinese medicine Sophora flavescens belongs to the legume family and contains a large number of alkaloids and flavonoids. Pharmacological experiments have proved that the alkaloids have diuretic, antiarrhythmic and anticancer activities. The total alkaloids of Sophora flavescens are mainly derived from the root of Sophora flavescens. It is a dark brown paste, slightly odor, and extremely bitter in taste. It also has the effects of diuresis, anti-arrhythmia, and immune system regulation. [0003] The total alkaloids of matrine have high medicinal value, and its industrial preparation methods are not widely reported in the patent literature, and the purity and color of the total alkaloids of matrine prepared cannot meet the standards, such as CN1594317C, the publication date is March 2005 On the 16th, it was pointed out that at that time there were on...

Claims

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Application Information

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IPC IPC(8): A61K36/489C07D471/22A61P7/10A61P9/06A61P35/00
Inventor 白锋云张勇汪晓东陈殿河
Owner NINGXIA BAUHINIA PHARMA
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