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Artificial bile duct bionic stent with double-layered compound structure and preparation method of artificial bile duct bionic stent

An artificial bile duct, double-layer composite technology, which is applied in the device of human tubular structure, medical science, prosthesis, etc., can solve the problems of bile leakage, cannot effectively support bile circulation, threaten the life of patients, etc., and prevent bile leakage. , Good clinical application prospects, the effect of avoiding secondary surgery

Inactive Publication Date: 2012-08-22
ZHEJIANG UNIV
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

However, due to the porous structure of the tissue-engineered bile duct stent, it cannot effectively support the flow of bile before the bile duct tissue is formed, and there is a risk of bile leakage, which greatly threatens the life of the patient

Method used

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  • Artificial bile duct bionic stent with double-layered compound structure and preparation method of artificial bile duct bionic stent
  • Artificial bile duct bionic stent with double-layered compound structure and preparation method of artificial bile duct bionic stent
  • Artificial bile duct bionic stent with double-layered compound structure and preparation method of artificial bile duct bionic stent

Examples

Experimental program
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Effect test

example 1

[0026] 1) Coat a polycaprolactone solution with a mass concentration of 15% on a glass rod with a diameter of 5.5 mm, dry it, and remove it from the glass rod to obtain a dense film-like polycaprolactone tube.

[0027] 2) Use the dense film-like polycaprolactone tube prepared in step 1) as the inner tube, and place a glass tube with an outer diameter of 7.5 mm on the outer coaxial line, and fill the gap between the polycaprolactone tube and the glass tube Gelatin particles with a particle size of 280 μm are then injected with an ethanol solution with a volume concentration of 85% to infiltrate the gelatin particles and placed at a temperature of 70 o C oven, after the gelatin particles are bonded, take it out and store it at -25 o Freeze at a temperature of C, freeze-dry, and remove the glass outer tube to obtain a composite tube whose inner layer is a polycaprolactone tube and whose outer layer is a gelatin particle adhesive layer.

[0028] 3) Soak the composite tube in step...

example 2

[0032] 1) Coating a poly(lactic acid-glycolic acid) copolymer solution with a mass concentration of 15% on a glass rod with a diameter of 2 mm, drying it, and removing it from the glass rod to obtain a dense film-like poly(lactic acid-glycolic acid) glycolic acid) copolymer tubing.

[0033] 2) The dense film-like poly(lactic acid-glycolic acid) copolymer tube prepared in step 1) was used as the inner tube, and a glass tube with an outer diameter of 6 mm was sleeved on the outer coaxial line, and the poly(lactic acid-glycolic acid) ) between the copolymer tube and the glass tube is filled with gelatin particles with a particle size of 450 μm, and then injected with an ethanol solution with a volume concentration of 85% to infiltrate the gelatin particles, and placed in a temperature of 70 o C oven, after the gelatin particles are bonded, take it out and store it at -25 o Frozen at a temperature of C, freeze-dried, and removed the outer glass tube to obtain a composite tube wit...

example 3

[0036] 1) Coat a polycaprolactone solution with a mass concentration of 15% on a glass rod with a diameter of 1 mm, let it dry in the air, and remove it from the glass rod to obtain a dense film-like polycaprolactone tube.

[0037] 2) Take the dense film-like polycaprolactone tube prepared in step 1) as the inner tube, set a glass tube with an outer diameter of 3 mm on the outer coaxial line, and fill the gap between the polycaprolactone tube and the glass tube Gelatin particles with a particle size of 250 μm are then injected with an ethanol solution with a volume concentration of 85% to infiltrate the gelatin particles, and placed at a temperature of 70 o C oven, after the gelatin particles are bonded, take it out and store it at -25 oFreeze at a temperature of C, freeze-dry, and remove the glass outer tube to obtain a composite tube whose inner layer is a polycaprolactone tube and whose outer layer is a gelatin particle adhesive layer.

[0038] 3) Soak the composite tube i...

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Abstract

The invention discloses an artificial bile duct bionic stent with a double-layered compound structure and a preparation method of the artificial bile duct bionic stent. The preparation method includes using biodegradable polyester as raw materials; preparing a compact membrane-shaped inner duct by a coating method; preparing a polyester outer duct with a communicated porous structure by a gelatin porogen method; and compounding the outer duct with the inner duct so as to obtain the artificial bile duct bionic stent with the double-layered compound structure. Repeatability of a preparation process is good. The inner duct of the artificial bile duct bionic stent can support bile circulation and prevent bile leakage, and the outer duct can support cell growth and regeneration to form new bile duct tissues. The artificial bile duct bionic stent is fine in biocompatibility, free of cytotoxicity and capable of realizing regeneration and repair of a bile duct, avoids secondary surgery, can be used for tissue engineering bile duct construction and bile duct coloboma repair, and has a good clinical application prospect.

Description

technical field [0001] The invention relates to the construction of a porous scaffold for tissue engineering, in particular to a method for preparing an artificial bile duct bionic scaffold with a double-layer composite structure by using degradable polyester as a material and a film coating method and a gelatin porogen method. Background technique [0002] Tissue engineering is an interdisciplinary research topic involving medicine, chemistry, biology, materials science and other disciplines and fields. In the study of tissue engineering, the selection of scaffold materials and the construction of scaffolds are the key links. Only by constructing a scaffold with a specific microstructure, excellent mechanical properties, suitable degradation properties, and good biocompatibility can it effectively promote cell adhesion and growth, and then guide the regeneration of tissues and organs. Polyester can be completely degraded in the body, and the products after degradation are ...

Claims

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Application Information

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IPC IPC(8): A61F2/04A61L27/18A61L27/56
Inventor 马列王美聪董洁王千千高长有
Owner ZHEJIANG UNIV
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