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Medicament for inhibiting oral bacterial plaque and preparation method thereof

A plaque and drug technology, which is applied in the field of drugs for inhibiting oral plaque and its preparation, can solve the problems of short action time of mouthwash, staining, and inconvenient carrying, so as to improve the oral health level, increase the surface area, and promote The effect of dissolution and absorption

Inactive Publication Date: 2012-10-03
FOURTH MILITARY MEDICAL UNIVERSITY
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0004] At present, mouthwashes such as stomatin and chlorhexidine are commonly used clinically and daily to reduce the adhesion of plaque in the oral cavity, thereby effectively reducing the incidence of dental caries. However, long-term use of such chemicals has certain side effects, such as making teeth, Staining occurs on the restoration or the back of the tongue; and the mouthwash has a short action time in the mouth, which is inconvenient to carry

Method used

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  • Medicament for inhibiting oral bacterial plaque and preparation method thereof
  • Medicament for inhibiting oral bacterial plaque and preparation method thereof
  • Medicament for inhibiting oral bacterial plaque and preparation method thereof

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0036] The preferred raw material components of the medicine of the present invention are as follows, and the following parts are parts by weight:

[0037]

[0038] The above raw material components are prepared according to the following scheme.

[0039] The preparation of the adhesive solution, the adhesive is povidone K-30 (PVP-K30), the wetting agent is 95% ethanol, the adhesive is dissolved in the wetting agent, and the concentration is 3%, that is, ;

[0040] Sucrose granulation, making sucrose with a binder (95% ethanol solution of 3% povidone K-30) into a soft material, granulating with a 24 mesh sieve, drying in an oven at 60°C for 5 hours, and sizing with a 20 mesh sieve;

[0041] Mix well, sieve Galla tannic acid, citric acid, blueberry essence, magnesium stearate and mix well; mix mannitol and sucrose granules; then mix the above two parts;

[0042] For tableting, a 10mm die is sufficient for tableting. During the tableting process, the temperature in the oper...

Embodiment 2

[0044] The ratio of parts by weight of the raw material components of the medicine of the present invention is as follows:

[0045]

[0046] The above raw material components are prepared according to the following scheme.

[0047] The preparation of the adhesive solution, the adhesive is povidone K-30 (PVP-K30), the wetting agent is 95% ethanol, the adhesive is dissolved in the wetting agent, and the concentration is 3%, that is, ;

[0048] Sucrose granulation, the sucrose is made into a soft material with a binder solution (95% ethanol solution of 3% povidone K-30), granulated through a 24 mesh sieve, dried in an oven at 60°C for 5 hours, and granulated through a 20 mesh sieve;

[0049] Mix well, sieve Galla tannic acid, citric acid, blueberry essence, magnesium stearate and mix well; mix mannitol and sucrose granules; then mix the above two parts;

[0050] For tableting, a 10mm die is sufficient for tableting. During the tableting process, the temperature in the operat...

Embodiment 3

[0052] The ratio of parts by weight of the raw material components of the medicine of the present invention is as follows:

[0053]

[0054]

[0055] The above raw material components are prepared according to the following scheme.

[0056] The preparation of the adhesive solution, the adhesive is povidone K-30 (PVP-K30), the wetting agent is 95% ethanol, the adhesive is dissolved in the wetting agent, and the concentration is 3%, that is, ;

[0057] Sucrose granulation, the sucrose is made into a soft material with a binder (95% ethanol solution of 3% povidone K-30), granulated through a 24-mesh sieve, dried in an oven at 60°C for 5 hours, and granulated through a 20-mesh sieve;

[0058] Mix well, will. Gallnut tannic acid, citric acid, blueberry essence, and magnesium stearate are sieved and mixed; mannitol and sucrose granules are mixed; the above two parts are mixed;

[0059] For tableting, a 10mm die is sufficient for tableting. During the tableting process, the te...

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Abstract

The invention relates to the field of oral medical treatment, in particular to a medicament for inhibiting oral bacterial plaque and a preparation method thereof. The medicament for inhibiting the oral bacterial plaque comprises gallnut tannic acid serving as a raw material and aids. The medicament comprises the following raw materials in part by weight: 4 to 8 parts of gallnut tannic acid, 200 to 300 parts of mannitol, 200 to 250 parts of sucrose particles, 10 to 20 parts of citric acid, 5 to 15 parts of blueberry essence, and 2 to 5 parts of magnesium stearate. The raw materials containing the gallnut tannic acid are prepared into tablets. By adopting the technical scheme, the medicament has the advantages that the chewable gallnut tablets can effectively control bacteria and bacterial plaque by chewing so as to inhibit dental caries; oral health can be effectively kept in special environments of water shortage; and particularly, the incidence of rampant caries, irritable oral ulcer, pericoronitis, plateau hypoxic gingivitis and periodontitis in a stress state is reduced.

Description

technical field [0001] The invention relates to a medicine for inhibiting oral plaque, in particular to a medicine for inhibiting oral plaque and a preparation method thereof. Background technique [0002] Dental caries is a progressive lesion of dental hard tissue caused by multiple factors in the oral cavity. It is manifested as demineralization of inorganic matter and decomposition of organic matter. With the development of the disease, the color changes to form substantial lesions. Evolution. It is characterized by high incidence and wide distribution. Generally, the average caries prevalence rate can be about 50%. It is a common disease of the oral cavity and one of the most common diseases of human beings. The World Health Organization has listed it as the three major human diseases for prevention and treatment along with cancer and cardiovascular and cerebrovascular diseases. [0003] Caries prevention has always been the focus of research at home and abroad. Due to...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K31/7024A61K9/20A61P1/02
Inventor 余擎田宇王晓娟李娜唐荣银
Owner FOURTH MILITARY MEDICAL UNIVERSITY
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