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Hydrophobic mesoporous nanomaterial and preparation method and application thereof

A technology of nanomaterials and mesoporous materials, applied in the field of hydrophobic mesoporous nanomaterials and their preparation, mesoporous nanomaterials and their preparation, can solve the problems of incomplete understanding and difficulties in the mechanism of action, and achieve the enhancement of low-intensity ultrasonic waves The effect of cavitation effect intensity, simple preparation method and mild reaction conditions

Active Publication Date: 2012-10-03
江苏先进无机材料研究院
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

However, its specific mechanism of action has not been fully understood, and it is still difficult to determine the parameters suitable for treatment such as nanoparticle type, particle concentration, ultrasound action time, intensity, frequency, etc.

Method used

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  • Hydrophobic mesoporous nanomaterial and preparation method and application thereof
  • Hydrophobic mesoporous nanomaterial and preparation method and application thereof
  • Hydrophobic mesoporous nanomaterial and preparation method and application thereof

Examples

Experimental program
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Effect test

preparation example Construction

[0052] 1) Preparation of ordered mesoporous material MCM-41

[0053] Add cetyltrimethylammonium bromide (CTAB) to 0.1-10mol / L NaOH aqueous solution, stir at 0-100°C until clear; add TEOS, stir evenly; conduct hydrothermal reaction at 25-200°C 1 ~48 hours; the molar ratio of raw materials added is: SiO 2 :NaOH:CTAB:H 2 O=1:(0.1~0.8):(0.1~0.6):(20~80); take out, filter, wash and dry to get the crude product PMCM; place the crude product PMCM in ethanol, then add 1mol / L Hydrochloric acid, the volume ratio of ethanol to hydrochloric acid is 100:1~10:1; after heating and refluxing for 1~24 hours, filter, wash, and dry to obtain a pore diameter of 2~50nm, a particle size of 20~800nm, and a specific surface area 100~2000m 2 / g of MCM-41 ordered mesoporous material.

[0054] 2) Preparation of ordered mesoporous material MCM-48

[0055] Add cetyltrimethylammonium bromide (CTAB) to 0.1-10mol / L NaOH aqueous solution, stir at 0-100°C until completely dissolved; add silica sol (SiO 2...

Embodiment 1

[0066] The pore diameter is 2nm, the particle size is 20nm, and the specific surface area is 1000m 2 / g of ordered mesoporous material MCM-41 was added to the reaction flask, then n-hexane was added to make it fully dispersed, then hexamethyldisilazane was added, and stirred at 25°C for 24h; ordered mesoporous material MCM-41 was mixed with The molar ratio of hexamethyldisilazane is 1:0.05; then it is washed with n-hexane and ethanol in sequence, and then dried at 30-200°C to obtain a hydrophobic mesoporous nanomaterial, denoted as HMSN.

[0067] Depend on figure 1 It can be seen that at 2962cm -1 The existence of the C-H bond vibration peak at , indicates that the methyl group is grafted into the ordered mesoporous material MCM-41 through silane coupling.

[0068] Add the prepared hydrophobic mesoporous nanomaterials and β-CD into water at a mass ratio of 1:0.3, stir at 25°C for 24 hours, then wash with water and dry to obtain the solubilized hydrophobic mesoporous nanomate...

Embodiment 2

[0077] The pore diameter is 10nm, the particle size is 200nm, and the specific surface area is 100m 2 / g of ordered mesoporous material MCM-41 was added to the reaction flask, then n-hexane was added to make it fully dispersed, and then 1,3-divinyl-1,1,3,3-tetramethyldisilazane was added , stirred at 60°C for 12h; the molar ratio of ordered mesoporous material MCM-41 to 1,3-divinyl-1,1,3,3-tetramethyldisilazane was 1:0.09; Wash with alkanes and ethanol in sequence, and then dry at 30-200°C to obtain hydrophobic mesoporous nanomaterials, denoted as HMSN.

[0078] Depend on Figure 6 It can be known that the pore diameter of the prepared hydrophobic mesoporous nanomaterial is 2.3nm; by Figure 7 It can be known that the specific surface area of ​​the prepared hydrophobic mesoporous nanomaterial is 1142m 2 / g; by Figure 8 It can be seen that the prepared hydrophobic mesoporous nanomaterials have a clear and uniform mesoporous structure; the measurement shows that the contact...

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Abstract

The invention discloses a hydrophobic mesoporous nanomaterial and a preparation method and application thereof. The hydrophobic mesoporous nanomaterial is prepared through condensation reaction of an ordered mesoporous material and a coupling reagent, wherein the coupling agent is selected from any one of the following formulae: Cl-SiR3 or RO-SiR3; and a group R contains a hydrophobic organic group. The hydrophobic mesoporous nanomaterial is introduced into a low-intensity ultrasonic system, the intensity of low-intensity ultrasonic cavitation effect can be enhanced; in-vitro and in-vivo experiments show that the hydrophobic mesoporous nanomaterial and the low-intensity ultrasonic have obvious synergistic effect and good cytocompatibility and relatively low cytotoxicity; and particularly, after solubilization, through combined use of the hydrophobic mesoporous nanomaterial with the low-intensity ultrasonic, the hydrophobic mesoporous nanomaterial can significantly inhibit the tumor growth and has a wide application prospect.

Description

technical field [0001] The present invention relates to a kind of mesoporous nano material and its preparation method and application, specifically, it relates to a kind of hydrophobic mesoporous nano material which can be used to enhance the intensity of low-intensity ultrasonic cavitation effect and its preparation method and application, which belongs to functional material technology field. Background technique [0002] At present, the incidence of tumors is getting higher and higher, and tumors have seriously threatened people's quality of life and life. Malignant tumors have become the number one killer of human health in this century. The treatment for tumors mainly includes surgical resection, chemotherapy and radiotherapy; however, all three treatment methods have obvious toxic and side effects, and none of them can be an effective means to cure tumors alone. Therefore, seeking a safe, effective, fast, and less toxic and side effect treatment has become a new topic...

Claims

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Application Information

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IPC IPC(8): C07F7/10A61K41/00A61K31/695A61P35/00
Inventor 祝迎春赵阳
Owner 江苏先进无机材料研究院
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