Purifying method of antioxidant 168
A purification method and antioxidant technology, applied in the field of antioxidant purification, can solve problems such as difficult to effectively remove impurities, and achieve the effect of being suitable for large-scale production, high yield, and high refining efficiency
- Summary
- Abstract
- Description
- Claims
- Application Information
AI Technical Summary
Problems solved by technology
Method used
Examples
Embodiment 1
[0024] Dissolve the crude antioxidant 168 in a mixed solvent (v / v) of ethyl acetate and methanol = 5:1 (w / v) 10 times its weight, heat to reflux temperature for 20 minutes, and let it cool at room temperature. Crystals were precipitated, and crystals were obtained after suction filtration. The above steps were repeated to obtain the second recrystallization product. After drying, the pure product of antioxidant 168 was obtained, with a yield of 96.2%. After HPLC detection, the obtained antioxidant 168 was pure, with a purity of 99.65%. The contents of impurity 1: 2,4-di-tert-butylphenol and impurity 2: 2,4-di-tert-butylphenoxyphosphorus dichloride were all equal. Less than 0.1%.
Embodiment 2
[0026] The detection of product: the product that embodiment 1 method obtains carries out detection result as follows:
[0027] 1. Melting point: 186°C
[0028] 2. Determination of impurity content:
[0029] Methods The HPLC method was adopted, and the chromatographic column was: C18 ODS column (250mm×4.6mm, 5μm); the mobile phase was acetone-methanol (50:50), and the flow rate was 0.5ml·min -1 , the detection wavelength is 275nm, the column temperature is 30 degrees, and the injection volume is 10 microliters. Test results: the content of 2,4-di-tert-butylphenol is 0.0923%; the content of 2,4-di-tert-butylphenoxyphosphorus dichloride is 0.0911%.
PUM
Property | Measurement | Unit |
---|---|---|
density | aaaaa | aaaaa |
density | aaaaa | aaaaa |
melting point | aaaaa | aaaaa |
Abstract
Description
Claims
Application Information
- R&D Engineer
- R&D Manager
- IP Professional
- Industry Leading Data Capabilities
- Powerful AI technology
- Patent DNA Extraction
Browse by: Latest US Patents, China's latest patents, Technical Efficacy Thesaurus, Application Domain, Technology Topic, Popular Technical Reports.
© 2024 PatSnap. All rights reserved.Legal|Privacy policy|Modern Slavery Act Transparency Statement|Sitemap|About US| Contact US: help@patsnap.com