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Biodegradable polymer braided stone-dissolving bile duct stent and preparation method thereof

A technology for degrading polymers and bile duct stents, which is used in the field of biodegradable polymer-woven lithotripsy bile duct stents and their preparation, can solve problems such as inability to carry out long-term continuous treatment, avoid adverse effects, maintain biliary tract patency, and achieve biological Good capacitive effect

Inactive Publication Date: 2012-10-17
SHANGHAI FIRST PEOPLES HOSPITAL
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

However, at present, the above-mentioned drugs can only be administered through local perfusion, and can only be used in surgical operations or postoperative drainage tubes, and cannot be used for long-term continuous treatment.

Method used

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Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0027] Fabrication of biodegradable polymer braided litholytic biliary stents:

[0028] (1) Take polycaprolactone as raw material, process it into a monofilament with a diameter of 0.2mm, and weave the monofilament into a braided support with a diameter of 8mm and a length of 80mm;

[0029] (2) According to the ratio of 20mg: 1ml, gelatin is dissolved in acetic acid to make a solution, and sodium cholate and disodium edetate with a mass ratio of 1mol: 1mol are evenly dispersed in the collagen solution, and treated by soaking, Place on the surface of the braided stent prepared in the above step (1) to make a biodegradable polymer braided litholytic bile duct stent.

Embodiment 2

[0031] A biodegradable polymer braided litholytic biliary stent was prepared by the following steps:

[0032] (1) Take polylactic acid: polyurethane as a ratio of 3:5 as raw material, process it into a monofilament with a diameter of 0.25mm, and weave the monofilament into a braided support with a diameter of 10mm and a length of 120mm;

[0033] (2) Dissolve collagen in glycerin at a ratio of 30mg: 1ml to make a solution, and disperse sodium cholate and disodium edetate with a mass ratio of 1mol: 2mol evenly in the collagen solution, and process it by spraying , placed on the surface of the braided stent prepared in the above step (1), and made into a biodegradable polymer braided litholytic bile duct stent.

Embodiment 3

[0035] Fabrication of biodegradable polymer braided litholytic biliary stents:

[0036] With polylactic acid: polyglycolic acid ratio of 3:4 copolymer as raw material, processed into a monofilament with a diameter of 0.21mm, the monofilament is braided into a braided scaffold with a diameter of 10mm and a length of 80mm; according to the ratio of 40mg: 1ml, Dissolve phosphorylcholine in glycerin to make a solution, uniformly disperse sodium cholate and edetate disodium with a mass ratio of 2mol:1mol in the phosphorylcholine solution, place it on the surface of the braided stent through soaking treatment, Litholytic biliary stents made of biodegradable polymer braids.

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Abstract

The invention, belonging to the field of biomedicine and bio-polymer material, particularly relates to a biodegradable polymer braided stone-dissolving bile duct stent and a preparation method thereof. The stent is prepared by braiding biodegradable polymers to obtain a porous reticulated or spiral tubular braided stent, and then coating a biodegradable drug loaded substance layer containing sodium cholate or / and edetate disodium on the inner surface and outer surface of the braided stent. Clinical outcomes show that the stone-dissolving bile duct stent of the invention has good radial supporting performance, can keep the bile duct open, can be degraded away in a certain time, has good biocompatibility, and lets almost no internal inflammation generate. Simultaneously, sodium cholate or / and edetate disodium slowly released by the polymer layer containing drugs can dissolve the formed stones and can prevent the re-formation of stones.

Description

technical field [0001] The invention belongs to the fields of biomedicine and biopolymer materials, and in particular relates to a biodegradable polymer braided litholytic bile duct stent and a preparation method thereof. Background technique [0002] According to clinical medical statistics, bile duct stones have a very high incidence rate. The traditional treatment method mainly adopts surgery, but the trauma is large, the complications are many, and the recurrence rate is high; Other diseases and cannot tolerate surgical treatment. In recent years, with the development of endoscopic technology, endoscopic pancreaticobiliary interventional stone removal technology (ERCP technology) has gradually become the main treatment method for bile duct stones, and has achieved good therapeutic effects. However, for some patients with difficult to remove bile duct stones (such as multiple, huge, hard or special bile duct stones), or patients who cannot tolerate long-term endoscopic o...

Claims

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Application Information

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IPC IPC(8): A61L31/10A61L31/16A61F2/90
Inventor 宛新建杨庆张佩华张伟星时翠红甄慧英
Owner SHANGHAI FIRST PEOPLES HOSPITAL
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