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Method, structure and targeted therapy device capable of forming conical dome-shaped gradient magnetic field

A gradient magnetic field and dome-shaped technology, which is applied in the field of equipment using the permanent magnet structure, can solve the problems of large magnetic flux leakage, large magnetic field dispersion space, and fast magnetic field attenuation, so as to achieve low manufacturing cost and improve positioning accuracy , The effect of magnetic field gradient enhancement

Inactive Publication Date: 2014-10-29
CHILDRENS HOSPITAL OF CHONGQING MEDICAL UNIV +6
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

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Problems solved by technology

However, the general single permanent magnet block or the combination of permanent magnet arrays without special configuration has fast magnetic field attenuation and more magnetic flux leakage, which leads to a large spatial range of magnetic field dispersion, so it is difficult to formulate target points. Most of the magnetic drug-loaded particles are gathered in the vicinity, but less in other non-target positions, so a guiding magnet that can present a relatively narrow magnetic field distribution at a certain depth is required

Method used

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  • Method, structure and targeted therapy device capable of forming conical dome-shaped gradient magnetic field
  • Method, structure and targeted therapy device capable of forming conical dome-shaped gradient magnetic field
  • Method, structure and targeted therapy device capable of forming conical dome-shaped gradient magnetic field

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Effect test

Embodiment 1

[0052] Such as figure 1 As shown, the magnet structure includes a main magnet 1 using a permanent magnet, a first auxiliary magnet 2, a second auxiliary magnet 3, a first wedge-shaped ferromagnetic block 4 and a second wedge-shaped ferromagnetic block 5;

[0053] The main bodies of the main magnet 1, the first auxiliary magnet 2 and the second auxiliary magnet 3 are square, and the main bodies of the first auxiliary magnet 2 and the second auxiliary magnet 3 are exactly the same, and the top and bottom surfaces of the three are all set to a square, wherein , the first auxiliary magnet 2 and the second auxiliary magnet 3 are respectively placed on both sides of the main magnet 1, and the three magnets are placed close to parallel in the manner of aligning adjacent sides, and the height of the first auxiliary magnet 2 and the second auxiliary magnet 3 is smaller than that of the main magnet. Magnet 1; the height difference between the two is h, and h can be appropriately increa...

Embodiment 2

[0060] Such as Figure 4 As shown, it is the top view of this embodiment. The difference between this embodiment and Embodiment 1 is that a hemispherical dome magnet structure 6 is added in this embodiment. The structure 6 is in the shape of a hemisphere, and the radius of the hemisphere is Half the side length of the horizontal section of the main magnet. By increasing the dome structure, it is more conducive to forming a tapered dome gradient magnetic field. When the dome is assembled, it can be stably and firmly placed on the main magnet due to the result of the attraction of opposites. In addition, in this embodiment, the height of the main magnet is 1 cm.

[0061] Figure 5 It is the magnet structure of embodiment two, the schematic diagram of the magnetic induction intensity distribution that upper working area produces, as Figure 5 As shown, the figure reveals that after adopting this structure, a more obvious cone-shaped dome gradient magnetic field can be formed...

Embodiment 3

[0064] Such as Image 6 As shown, it is the top view of this embodiment. The difference between this embodiment and Embodiment 1 is that The main body of the main magnet 1, the first auxiliary magnet 2 and the second auxiliary magnet 3 is square, and the top and bottom surfaces of the three are all set to be rectangular, and the structure is in the shape of a hemisphere, and the radius of the dome is the horizontal section of the main magnet. half the length of the shorter side. In addition, in this embodiment, the height of the main magnet is 20 cm.

[0065] It should be emphasized that, In terms of material selection for the main magnet, the first auxiliary magnet and the second auxiliary magnet, neodymium iron boron, samarium cobalt or ferrite can be used, while the first wedge-shaped ferromagnetic block and the second wedge-shaped ferromagnetic block can be made of iron, cobalt , or nickel, or an alloy containing one or more of iron, cobalt, and nickel, or an oxide co...

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Abstract

The invention discloses a method and a structure capable of forming a conical and dome-shaped gradient magnetic field as well as targeting therapy equipment. The method comprises the following steps of: step 1, using a square permanent magnet as a main magnet body, and using two square permanent magnets which are lower than the main magnet body as auxiliary magnet bodies, wherein the auxiliary magnet bodies are arranged at both sides of the main magnet body; and a magnetic moment direction of the main magnet body is the same as that of a first auxiliary magnet body and a second auxiliary magnet body; and step 2, respectively arranging wedged ferromagnetic blocks on the top surfaces of the two auxiliary magnet bodies by means that the inclined surfaces of the wedged ferromagnetic blocks face upwards, one square surface of each wedged ferromagnetic block is adhered to the top surface of the corresponding auxiliary magnet body, and the other square surface of each wedged ferromagnetic block is adhered to the side surface of the main magnet body, so that the two wedged ferromagnetic blocks are symmetrically distributed at both sides of the main magnet body in a splayed manner; and the conical and dome-shaped gradient magnetic field is formed at the top of the main magnet body. The magnet structure provided by the invention can be used as a magnetic drug targeting guide magnet body, so that magnetic drug grains are controlled within a smaller space according to the distribution of a compact magnetic field and gradient of the magnetic field; and the positioning accuracy of targeting therapy is improved.

Description

technical field [0001] The invention relates to a method capable of forming a tapered dome-shaped gradient magnetic field, and also relates to a permanent magnet structure capable of forming a tapered dome-shaped gradient magnetic field and a device using the permanent magnet structure. Background technique [0002] At present, the clinical treatment of diseases such as tumors, tuberculosis, and osteomyelitis mainly relies on the systemic administration of chemical drugs, which has a certain therapeutic effect, but the dosage is large and the systemic side effects are serious. [0003] Among malignant tumor patients, about 80% of lung cancer patients are non-small cell lung cancer, including squamous cell carcinoma and adenocarcinoma. About 85% of these patients are in the middle and late stage when they are diagnosed, and about 75% of advanced non-small cell lung cancer patients have lost The chances of surgery for radical treatment and the clinical effects of conventional ...

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): G01R33/381A61M31/00
Inventor 罗聪何为李廷玉徐征何通川李明黄华朱朝敏段波单雪峰籍勇亮
Owner CHILDRENS HOSPITAL OF CHONGQING MEDICAL UNIV