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Intelligent natural polymer-synthetic polymer copolymer microgel and preparation method thereof

A technology of natural polymers and microgels, applied in the direction of non-active components of polymer compounds, coatings, protein coatings, etc., can solve the problems of poor biocompatibility and biodegradability, increased product purification, difficulty, etc., to achieve The effect of great application potential, simple preparation method and low cost

Inactive Publication Date: 2012-10-31
CHENGDU ORGANIC CHEM CO LTD CHINESE ACAD OF SCI
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0003] Chinese patent CN1847473A discloses a method of using N-isopropylacrylamide and acrylic acid as main monomers in the presence of crosslinking agents and emulsifiers to initiate polymerization to prepare microgels with dual responses to pH and temperature, but the method uses The emulsifier is added, which increases the difficulty of product purification in the later stage
The preparation methods of the microgels involved in the above patents or documents are all based on synthetic polymers, which have the disadvantages of poor biocompatibility and biodegradability

Method used

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Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0012] With stirring, reflux condenser, thermometer and N 2 Add 0.25g casein, 0.1gNa 2 CO 3 and 50g of deionized water, stirred in a water bath at 50°C for 30min, then added 1g of N-isopropylacrylamide and 0.01g of polyethylene glycol diacrylate, stirred for 15min, heated to 80°C, and passed through N 2 30min, add initiator TBHP7.2x10 -4 g (0.8mL10mmol / L), N 2 Reaction under protection for 2h. The obtained product is fully dialyzed with distilled water (dialysis bag, molecular weight cut-off is 10000), and then freeze-dried to obtain the target product casein-grafted N-isopropylacrylamide copolymer microgel. It is a pH- and temperature-responsive microgel with low cross-linking degree, the pH value is 4.6 when the swelling rate is the smallest, and the response temperature is 32°C.

Embodiment 2

[0014] With stirring, reflux condenser, thermometer and N 2 Add 0.25g casein, 0.1g Na 2 CO 3 and 50g of deionized water, stirred at 50°C for 30min, then added 1g of N-isopropylmethacrylamide and 0.01g of N,N-methylenebisacrylamide, stirred for 15min, heated to 80°C, and passed through N 2 30min, add initiator TBHP7.2x10 -4 g (0.8mL10mmol / L), N 2 Reaction under protection for 2h. The obtained product is fully dialyzed with distilled water (dialysis bag, molecular weight cut-off is 10000), and then freeze-dried to obtain the target product casein-grafted N-isopropylacrylamide copolymer microgel. It is a pH- and temperature-responsive microgel with low cross-linking degree, the pH value is 4.6 when the swelling rate is the smallest, and the response temperature is 32°C.

Embodiment 3

[0016] With stirring, reflux condenser, thermometer and N 2 Add 0.25g gelatin, 0.1g Na 2 CO 3 and 50g of deionized water, stirred at 50°C for 30min, then added 1g of N,N-diethylacrylamide and 0.03g of N,N-methylenebisacrylamide, stirred for 15min, heated to 80°C, and passed through N 2 30min, add initiator TBHP7.2x10 -4 g (0.8mL10mmol / L), N 2 Reaction under protection for 2h. The obtained product is fully dialyzed with distilled water (dialysis bag, molecular weight cut-off is 10000), and then freeze-dried to obtain the target product gelatin-grafted N-isopropylacrylamide copolymer microgel. It is a pH- and temperature-responsive microgel with a moderate degree of crosslinking, the pH value is 4.8 when the swelling rate is the smallest, and the response temperature is 32°C.

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Abstract

The invention relates to intelligent natural polymer-synthetic polymer copolymer microgel and a preparation method thereof. The microgel is obtained by soap-free emulsion polymerization and is composed of natural polymers and synthetic polymers, wherein the natural polymers are casein, gelatin, bovine serum albumin and other natural amphoteric polyelectrolytes, and the synthetic polymers are alkylated acrylamide polymers with a temperature responsive property. The microgel is responsive to both pH and temperature; and the biomacromolecule portion contained in the microgel has good biocompatibility and biodegradability and the synthetic polymer portion has a temperature responsive property. Therefore, the microgel can be used as a base material of intelligent drug carriers, controlled-release materials and biosensors and has good application prospects in the fields of biomedicine and pharmacy.

Description

technical field [0001] The invention relates to a preparation method of an intelligent microgel, in particular to a copolymer microgel with dual response to pH and temperature and a preparation method thereof, belonging to the technical field of functional polymer materials and pharmaceutical auxiliary materials. Background technique [0002] Microgel is a cross-linked microparticle with a diameter of 50nm-5μm and an internal structure of a typical network structure. It can be considered a hydrogel if it contains a water soluble or water swellable part. Environment-responsive microgel refers to that when external factors such as temperature, pH value, and ionic strength change, swelling or deswelling behavior occurs inside the microgel, which causes the volume of the microgel to swell or shrink, and causes A class of microgels that vary in properties such as pore size and rheology. In the past, there were many studies on microgels that respond to a single stimulus, but wit...

Claims

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Application Information

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IPC IPC(8): C08F289/00C08F220/54C08H1/00A61K47/42C09D189/00
Inventor 金勇曹志峰漆瑞马春彦
Owner CHENGDU ORGANIC CHEM CO LTD CHINESE ACAD OF SCI
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