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Vertical interactive electron bombardment electron spray ion source-flight time mass spectrograph

A technology of time-of-flight mass spectrometry and electron bombardment of ions, which is applied in the field of mass spectrometry to achieve the effect of improving utilization efficiency and practical performance

Inactive Publication Date: 2012-11-28
王利兵
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0007] It is not difficult to find that although there are many reports on the application of dual ion sources connected to serial mass analyzers in the above technical background, their main purpose is to improve the ionization efficiency of the compounds to be tested in the sample, but not to truly meet the requirements of multi-morphic samples. Simultaneous ionization requirements

Method used

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  • Vertical interactive electron bombardment electron spray ion source-flight time mass spectrograph
  • Vertical interactive electron bombardment electron spray ion source-flight time mass spectrograph
  • Vertical interactive electron bombardment electron spray ion source-flight time mass spectrograph

Examples

Experimental program
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Effect test

Embodiment 1

[0027] Example 1 Electron bombardment-time-of-flight working mode.

[0028] Such as figure 1 and figure 2 As shown, the gaseous compound to be measured is directly input into the bombardment ionization chamber (41) of the electron bombardment ion source from the quartz capillary column (36) along with the helium flow, and the vacuum degree of the bombardment ionization chamber (41) is controlled by the backstage mechanical pump and the molecular turbine. Pump combined to reach 10 -4 below pa; the voltage loaded on the filament (39) excites the filament (39) to emit electrons with an energy of 70 eV, and the electron beam collides with the sample molecules in the vertical direction on the way to the anode (38) and makes them Break into charged fragments with different mass-to-charge ratios; the charged fragment ions are modulated by the electric lens group (42) under the action of the repeller (40) into electron bombardment ion beams (44), and pass through the shield locat...

Embodiment 2

[0030] Example 2 Electrospray-time-of-flight working mode.

[0031] Such as figure 1 and figure 2 As shown, after the liquid sample is injected into the electrospray nozzle (1), the high-voltage electric field at the tip of the electrospray nozzle (1) ionizes the outflowing droplets; the charged droplets are rapidly atomized and removed in the spray chamber (2). Solvation, and then the charged ions flow through the stainless steel capillary (3) into the mass spectrometer vacuum chamber (5), and desolvate through the sampling cone (7); the triple quadrupole ion transmission system acts as a radially connected electrospray ion source The role of the vertical introduction time-of-flight mass analyzer, including the quadrupole (8), molecular ion reactor (9) and quadrupole (10); the screened ions are then modulated by the electric lens group (11) into an electric After spraying the ion beam (43), it passes through the entrance slit (12) of the electrospray ion beam and the entr...

Embodiment 3

[0033] Example 3 Electron bombardment electrospray-time-of-flight working mode.

[0034] Such as image 3 As shown, while the gaseous sample is ionized in the bombardment ionization chamber (41) according to the approach and method shown in Example 1, the liquid sample is ionized in the electrospray nozzle (1) of the electrospray ion source according to the approach shown in Example 2 ) at the tip of the needle; the electron bombardment ion beam (44) introduced vertically from the Z direction through the electric lens group (42) and the electrospray ion beam (43) introduced vertically from the X direction through the electric lens group (11) are in the bombardment Intersection in the repulsion zone of the acceleration zone (21) of the time-of-flight mass analyzer, after mixing, it is repelled and accelerated along the Y direction; whether it is a single ion in Example 1 and Example 2 or a mixed ion in this example, their trajectory are roughly coincident: through the accelera...

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Abstract

A vertical interactive electron bombardment electron spray ion source-flight time mass spectrograph is characterized in that the vertical interactive electron bombardment electron spray ion source-flight time mass spectrograph comprises an electron bombardment ion source, an electron spray ion source and a two-way vertical lead-in type flight time mass analyzer; and the electron bombardment ion source, the electron spray ion source and the two-way vertical lead-in type flight time mass analyzer are perpendicular to each other. The vertical interactive electron bombardment electron spray ion source-flight time mass spectrograph can achieve automatic switching between three working modes of an electron bombardment-flight time mode, an electron spray-flight time mode and an electron bombardment electron spray-flight time mode. Vacuum accessories such as multi-stage vacuum cavities, preceding stage mechanical pumps and turbo-molecular pumps and the like are arranged on the vertical interactive electron bombardment electron spray ion source-flight time mass spectrograph, so as to ensure the high vacuum degree that is needed when relevant parts of the electron bombardment ion source operate normally. The vertical interactive electron bombardment electron spray ion source-flight time mass spectrograph combines the electron bombardment ion source capable of ionizing gaseous samples, the electron spray ion source capable of ionizing liquid samples and vertical lead-in type flight time mass analyzer in an extension manner, and improves the utilization efficiency and the practical performance of the flight time mass analyzer.

Description

technical field [0001] The invention belongs to the technical field of mass spectrometry, and in particular relates to a dual ion source-time-of-flight mass spectrometer of vertical interactive electron bombardment composite electrospray. Background technique [0002] Organic mass spectrometer is an important instrument for structure identification and content determination of organic compounds. In the organic mass spectrometer, the mass analyzer is the core component in the organic mass spectrometer. According to the principle of mass selection and separation, currently widely used mass analyzers include quadrupole mass analyzers, ion trap mass analyzers, time-of-flight mass analyzers and magnetic mass analyzers, etc., in chemical analysis, drug synthesis, biomedicine, etc. It has been widely used in metabolomics and clinical medicine. In recent years, with the continuous expansion of the application and development field of mass spectrometers, as well as the diversity an...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): H01J49/40H01J49/02
Inventor 王利兵丁利清江于艳军苏荣欣胥传来侯尧
Owner 王利兵
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