Local externally-applied antalgic compound preparation composition for skin and preparation method thereof
A compound preparation and composition technology, applied in the field of medicine, can solve the problems of no research reports, no lidocaine hydrochloride, etc., and achieve the effect of long drug effect time, less pain and less side effects
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Embodiment 1
[0019] Embodiment 1, Preparation and effect verification of compound paint for external use
[0020] This example relates to a skin topical analgesic compound preparation composition, the preparation method of which comprises the following steps: weigh 50 g of lidocaine hydrochloride and 2 g of ropivacaine hydrochloride and dissolve them in an appropriate amount of purified water; separately take carboxymethyl cellulose Swell 20g of sodium in an appropriate amount of hot purified water, add 50g of glycerin, 100g of urea to dissolve and 10g of 5% ethylparaben alcohol solution; combine the two liquids, add purified water to the full amount of 1000g, stir well, and subpackage, remember the final product compound for external use lotion.
[0021] Carboxymethylcellulose sodium (CMC-Na) in the compound paint for external use in this embodiment can increase the consistency of the paint, which is beneficial to prolong the action time of the drug; glycerin has a moisturizing effect an...
Embodiment 2
[0026] Embodiment 2, Preparation and effect verification of compound cream for external use
[0027] This example relates to a compound preparation composition for topical skin analgesia, the preparation method of which comprises the following steps: weighing 20 g of lidocaine hydrochloride, 20 g of ropivacaine hydrochloride, 50 g of glycerin and 10 g of sodium lauryl sulfate dissolved in 600g of hot purified water (70°C) to obtain the water phase; separately take 140g of white petrolatum, 80g of stearyl alcohol, 60g of liquid paraffin, 20g of azone and 1g of ethyl paraben, heat it on a water bath to 70°C, and melt to obtain the oil phase; Add the water phase to the oil phase while stirring constantly, and stir in the same direction until it is completely emulsified, then add purified water to a total amount of 1000g, stir well, and divide into packages to obtain the final compound cream for external use.
[0028] In the compound cream for external use of the present embodim...
Embodiment 3
[0033] Embodiment 3, Preparation of compound gel for external use and its effect verification
[0034] This example relates to a skin topical analgesic compound preparation composition, the preparation method of which comprises the following steps: according to the prescription, 5 g of lidocaine hydrochloride and 20 g of ropivacaine hydrochloride are dissolved in an appropriate amount of purified water; (Carbomer-940) 10g was swollen in an appropriate amount of hot purified water, added 50g of glycerin, 20g of azone and 6g of 5% ethylparaben alcohol solution; combined the two liquids, adjusted the pH to 6.0 with triethanolamine, and added purified water to The whole amount is 1000g, stirred evenly, and divided to obtain the final compound gel for external use.
[0035] In the compound gel for external use of this embodiment, carbomer-940 is used as the matrix material of the gel, and the viscosity is the best when the pH is near neutral; glycerin has a moisturizing effect an...
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