Drug combination of mezlocillin sodium for injection and preparation method of same
A technology of mezlocillin and a composition is applied in the field of mezlocillin sodium nanoparticle injection for injection and its preparation field, which can solve the problems of undisclosed mezlocillin sodium nanoparticle injection and the like, and achieves good resolubility and stability. , the effect of excellent stability
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Embodiment 1
[0056] The preparation of embodiment 1 mezlocillin sodium nanoparticle injection
[0057] Prescription 100 bottles
[0058] Mezlocillin Sodium 600g
[0059] n-Butyl cyanoacrylate 700g
[0060] Polyethylene glycol 7g
[0061] Lactose 500g.
[0062] Preparation Process:
[0063] (1) Add 200g of mezlocillin sodium and 7g of polyethylene glycol into 2.4L of water for injection, stir to dissolve, and adjust the pH to 2.0-3.0 with sulfuric acid;
[0064] (2) Add 700g of n-butyl cyanoacrylate to the above solution under stirring, stir at room temperature for 6 hours, add 500g of lactose, continue stirring until completely dissolved, and adjust the pH to 4.0-6.0 with sodium hydroxide;
[0065] (3) above-mentioned solution is adopted 0.22 μ m microporous membrane filtration, obtains mezlocillin sodium nanoparticle solution;
[0066] (4) Dispense the above solution into sterilized vials, pre-freeze at -40°C to -50°C for 3 hours, freeze-dry with a freeze dryer, seal with a sterile...
Embodiment 2
[0067] The preparation of embodiment 2 mezlocillin sodium nanoparticle injection
[0068] Prescription 100 bottles
[0069] Mezlocillin Sodium 200g
[0070] Propyl cyanoacrylate 600g
[0071] Polyethylene glycol 6g
[0072] Mannitol 600g.
[0073] Preparation Process:
[0074] (1) Add 200g of mezlocillin sodium and 6g of polyethylene glycol into 2L of water for injection, stir to dissolve, and adjust the pH to 2.0-3.0 with formic acid;
[0075] (2) Add 600g of propyl cyanoacrylate to the above solution under stirring, stir at room temperature for 5 hours, add 600g of mannitol, continue stirring until completely dissolved, and adjust the pH to 4.0-7.0 with sodium bicarbonate;
[0076] (3) above-mentioned solution is adopted 0.22 μ m microporous membrane filtration, obtains mezlocillin sodium nanoparticle solution;
[0077] (4) Dispense the above solution into sterilized vials, pre-freeze at -40°C to -50°C for 3 hours, freeze-dry with a freeze dryer, seal with a sterile ru...
Embodiment 3
[0078] The preparation of embodiment 3 mezlocillin sodium nanoparticle injection
[0079] Prescription 100 bottles
[0080] Mezlocillin Sodium 200g
[0081] n-Butyl cyanoacrylate 600g
[0082] Poloxamer 6g
[0083] Glucose 600g.
[0084] Preparation Process:
[0085] (1) Add 100g of mezlocillin sodium and 5g of poloxamer to 2L of water for injection, stir to dissolve, and adjust the pH to 1.0-2.0 with hydrochloric acid;
[0086] (2) Add 600g of n-butyl cyanoacrylate to the above solution under stirring, stir at room temperature for 5 hours, add 600g of glucose, continue stirring until completely dissolved, and adjust the pH to 4.0-7.0 with sodium bicarbonate;
[0087] (3) above-mentioned solution is adopted 0.22 μ m microporous membrane filtration, obtains mezlocillin sodium nanoparticle solution;
[0088] (4) Dispense the above solution into sterilized vials, pre-freeze at -40°C to -50°C for 3 hours, freeze-dry with a freeze dryer, seal with a sterile rubber stopper, an...
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