Drug combination of mezlocillin sodium for injection and preparation method of same

A technology of mezlocillin and a composition is applied in the field of mezlocillin sodium nanoparticle injection for injection and its preparation field, which can solve the problems of undisclosed mezlocillin sodium nanoparticle injection and the like, and achieves good resolubility and stability. , the effect of excellent stability

Inactive Publication Date: 2013-01-16
海南美好西林生物制药有限公司
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

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Problems solved by technology

[0003] After searching, the current national patent office has not published relevant patents on mezlocillin sodium nanoparticle injection and its preparation method

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  • Drug combination of mezlocillin sodium for injection and preparation method of same
  • Drug combination of mezlocillin sodium for injection and preparation method of same

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Experimental program
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Effect test

Embodiment 1

[0056] The preparation of embodiment 1 mezlocillin sodium nanoparticle injection

[0057] Prescription 100 bottles

[0058] Mezlocillin Sodium 600g

[0059] n-Butyl cyanoacrylate 700g

[0060] Polyethylene glycol 7g

[0061] Lactose 500g.

[0062] Preparation Process:

[0063] (1) Add 200g of mezlocillin sodium and 7g of polyethylene glycol into 2.4L of water for injection, stir to dissolve, and adjust the pH to 2.0-3.0 with sulfuric acid;

[0064] (2) Add 700g of n-butyl cyanoacrylate to the above solution under stirring, stir at room temperature for 6 hours, add 500g of lactose, continue stirring until completely dissolved, and adjust the pH to 4.0-6.0 with sodium hydroxide;

[0065] (3) above-mentioned solution is adopted 0.22 μ m microporous membrane filtration, obtains mezlocillin sodium nanoparticle solution;

[0066] (4) Dispense the above solution into sterilized vials, pre-freeze at -40°C to -50°C for 3 hours, freeze-dry with a freeze dryer, seal with a sterile...

Embodiment 2

[0067] The preparation of embodiment 2 mezlocillin sodium nanoparticle injection

[0068] Prescription 100 bottles

[0069] Mezlocillin Sodium 200g

[0070] Propyl cyanoacrylate 600g

[0071] Polyethylene glycol 6g

[0072] Mannitol 600g.

[0073] Preparation Process:

[0074] (1) Add 200g of mezlocillin sodium and 6g of polyethylene glycol into 2L of water for injection, stir to dissolve, and adjust the pH to 2.0-3.0 with formic acid;

[0075] (2) Add 600g of propyl cyanoacrylate to the above solution under stirring, stir at room temperature for 5 hours, add 600g of mannitol, continue stirring until completely dissolved, and adjust the pH to 4.0-7.0 with sodium bicarbonate;

[0076] (3) above-mentioned solution is adopted 0.22 μ m microporous membrane filtration, obtains mezlocillin sodium nanoparticle solution;

[0077] (4) Dispense the above solution into sterilized vials, pre-freeze at -40°C to -50°C for 3 hours, freeze-dry with a freeze dryer, seal with a sterile ru...

Embodiment 3

[0078] The preparation of embodiment 3 mezlocillin sodium nanoparticle injection

[0079] Prescription 100 bottles

[0080] Mezlocillin Sodium 200g

[0081] n-Butyl cyanoacrylate 600g

[0082] Poloxamer 6g

[0083] Glucose 600g.

[0084] Preparation Process:

[0085] (1) Add 100g of mezlocillin sodium and 5g of poloxamer to 2L of water for injection, stir to dissolve, and adjust the pH to 1.0-2.0 with hydrochloric acid;

[0086] (2) Add 600g of n-butyl cyanoacrylate to the above solution under stirring, stir at room temperature for 5 hours, add 600g of glucose, continue stirring until completely dissolved, and adjust the pH to 4.0-7.0 with sodium bicarbonate;

[0087] (3) above-mentioned solution is adopted 0.22 μ m microporous membrane filtration, obtains mezlocillin sodium nanoparticle solution;

[0088] (4) Dispense the above solution into sterilized vials, pre-freeze at -40°C to -50°C for 3 hours, freeze-dry with a freeze dryer, seal with a sterile rubber stopper, an...

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Abstract

The invention discloses a drug combination of mezlocillin sodium, namely mezlocillin sodium nanoparticle injection which comprises mezlocillin sodium, a carrier material, a stabilizing agent and an excipient. The average effective particlesize of nanoparticle is 10 to 20 nm. The preparation method of the injection comprises the steps of mixing the mezlocillin sodium and the stabilizing agent in water for injection, adjusting pH value, and then adding the carrier material and the excipient into the mezlocillin sodium and the stabilizing agent. The mezlocillin sodium nanoparticle injection has the advantages of good re-solubility, good stability, high drug loading capacity and the like, and the method is suitable for industrial production.

Description

technical field [0001] The invention belongs to the technical field of medicine, and relates to a pharmaceutical composition of mezlocillin sodium for injection and a preparation method thereof, and to a mezlocillin sodium nanoparticle injection for injection and a preparation method thereof. Background technique [0002] Azlocillin is a semi-synthetic penicillin antibiotic that is effective against Pseudomonas aeruginosa, Escherichia coli, Klebsiella pneumoniae, Proteus, Enterobacter, Citrobacter, Serratia, and Acinetobacter Both genera and penicillin-sensitive Gram-positive cocci have antibacterial effects, and large doses have bactericidal effects. The antibacterial activity against Escherichia coli, Enterobacter, Klebsiella pneumoniae, Citrobacter, Serratia, and Acinetobacter is stronger than that of carbenicillin and ampicillin; against indole-positive Proteus, Pseudomonas aeruginosa The antibacterial activity against gram-positive bacteria such as Staphylococcus aureu...

Claims

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Application Information

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IPC IPC(8): A61K9/10A61K31/431A61P31/04
Inventor 魏雪纹李强
Owner 海南美好西林生物制药有限公司
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