Method for preparing telomerase polypeptide vaccine

A technology of polypeptide vaccine and telomerase, which is applied in the preparation methods of peptides, chemical instruments and methods, peptides, etc., and can solve the problems of unprovided technical process, unlisted product purity, yield, etc.
CN102875657AInactive Publication Date: 2013-01-16NANJING UNIV OF TECH
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Patent Information

Authority / Receiving Office
CN Β· China
Patent Type
Applications(China)
Current Assignee / Owner
NANJING UNIV OF TECH
Publication Date
2013-01-16
Estimated Expiration
Not applicable Β· inactive patent

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Abstract

The invention discloses a method for preparing telomerase polypeptide vaccine GV1001. The method includes the steps of firstly, subjecting Fmoc-L-Lys(Boc)-OH and solid synthetic resin as starter materials to reaction so as to obtain Fmoc-L-Lys(Boc)-resin; secondly, subjecting the Fmoc-L-Lys(Boc)-resin to gradual coupling to obtain side-chains-protected GV1001-resin according to a polypeptide sequence of GV1001 by Fmoc solid-phase synthesis; thirdly, decomposing the side-chains-protected GV1001-resin by decomposing reagent, adding precipitating reagent to allow for precipitation so as to obtain crude peptide, and purifying and freeze-drying the crude peptide to obtain the telomerase polypeptide vaccine GV1001. The method for preparing the telomerase polypeptide vaccine GV1001 has practical industrial application prospect and considerable economic and practical values.
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Description

technical field

[0001] The invention belongs to the technical field of pharmacy, and in particular relates to a method for preparing telomerase polypeptide vaccine GV1001. Background technique

[0002] Malignant tumor is a common disease that threatens human life and health. The current surgical treatment, radiotherapy, drug treatment and other methods have no significant therapeutic effects on some malignant tumors, and the side effects after treatment are large. Studies have confirmed that the activation of telomerase and the regulation of telomere length are closely related to tumor formation, and have a high degree of specificity in the process of tumor treatment. In recent years, there have been many reports on the relationship between telomerase expression and tumor formation and development, and good progress has been made in tumor therapy targeting telomerase.

[0003] In 1999, the world patent WO00 / 02581 disclosed a series of antigenic polypeptides derived from te...

Claims

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