Artificial cornea porous support material and preparation method thereof

A porous scaffold and artificial cornea technology, applied in medical science, prosthesis, etc., can solve the problems of inability to combine corneal tissue biologically and meet the requirements of artificial cornea porous scaffold materials, and achieve good biocompatibility and high mechanical properties , The effect of simple process

Inactive Publication Date: 2013-01-23
深圳华明生物科技有限公司
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Problems solved by technology

However, since polyvinyl alcohol has no biological activity and cannot be biologically combined with corneal tissue, it cannot be permanently and firmly fixed in the eye
[0005] However, the above-mentioned simple inorganic phase or organic phase cannot meet the requirements as a porous scaffold material for artificial cornea due to their respective deficiencies.

Method used

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  • Artificial cornea porous support material and preparation method thereof

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preparation example Construction

[0015] The present invention also provides a kind of preparation method of artificial cornea porous support material, comprises steps:

[0016] In the first step, polyvinyl alcohol hydrogel is prepared by using polyvinyl alcohol.

[0017] In this step, polyvinyl alcohol can be added into an aqueous solution with a temperature of 85-90°C and a volume percentage of 40%-70% dimethyl sulfoxide and heated at a constant temperature for 2 hours to prepare a polyvinyl alcohol hydrogel.

[0018] In the second step, adding β-tricalcium phosphate and graphite to the polyvinyl alcohol hydrogel to obtain a scaffold material mixture, the weight ratio of the β-tricalcium phosphate to graphite is 1:4 to 4:1, the The weight ratio of β-tricalcium phosphate to polyvinyl alcohol is 1:5 to 2:1, and the weight ratio of graphite to polyvinyl alcohol is 1:5 to 2:1.

[0019] In this step, a porogen can also be added to the polyvinyl alcohol hydrogel, and the porogen is glucose, potassium chloride, so...

Embodiment 1

[0025] A kind of β-tricalcium phosphate / graphite / polyvinyl alcohol composite hydrogel porous scaffold material for artificial cornea, its preparation method comprises the following steps:

[0026] In the first step, 2 g of polyvinyl alcohol is added to an aqueous solution with a temperature of 85 ° C and a volume percentage of 60% dimethyl sulfoxide and heated at a constant temperature for 2 hours to prepare a polyvinyl alcohol hydrogel;

[0027] In the second step, 0.5g of β-tricalcium phosphate, 0.5g of graphite and 5g of glucose were directly added to the polyvinyl alcohol hydrogel and stirred at a constant temperature in a water bath at 90°C for 2 hours to obtain a mixture;

[0028] In the third step, the mixture is directly injected into a sterile mold and subjected to repeated freezing and molding at -40°C to obtain a frozen-molded scaffold material;

[0029] Finally, soak the freeze-formed scaffold material in sterile deionized water and sterilize it with iodine to obta...

Embodiment 2

[0031] A kind of β-tricalcium phosphate / graphite / polyvinyl alcohol composite hydrogel porous scaffold material for artificial cornea, its preparation method comprises the following steps:

[0032] In the first step, 4 g of polyvinyl alcohol is added to an aqueous solution with a temperature of 90 ° C and a volume percentage of 40% dimethyl sulfoxide and heated at a constant temperature for 2 hours to prepare a polyvinyl alcohol hydrogel;

[0033] In the second step, 2 g of β-tricalcium phosphate, 3 g of graphite and 20 g of glucose are directly added to the polyvinyl alcohol hydrogel and stirred at a constant temperature in a water bath at 90° C. for 2 hours to obtain a mixture;

[0034] In the third step, the mixture is directly injected into a sterile mold and subjected to repeated freezing and molding at a temperature of -35° C. to obtain a scaffold material after freezing;

[0035] Finally, soak the freeze-formed scaffold material in sterile deionized water and sterilize i...

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Abstract

The invention is suitable for the technology of implant materials and artificial organs in medical equipment, and provides an artificial cornea porous support material. The artificial cornea porous support material is beta-tertiary calcium phosphate/ graphite/ polyvinyl alcohol composite hydrogel; in the artificial cornea porous support material, the weight ratio of beta-tertiary calcium phosphate to graphite is (4: 1)-(1: 4); the weight ratio of beta-tertiary calcium phosphate to polyvinyl alcohol is (1: 5)-(2: 1); and the weight ratio of graphite to polyvinyl alcohol is (1: 5)-(2: 1). The invention also provides a preparation method of the artificial cornea porous support material.

Description

technical field [0001] The invention belongs to the technical field of implant materials and artificial organs in medical devices, and in particular designs a porous artificial cornea support material and a preparation method thereof. Background technique [0002] The main component of β-tricalcium phosphate ceramics is composed of calcium and phosphorus elements. It does not contain protein components, is non-toxic, has good biocompatibility and cell affinity, and can conduct tissue growth, that is, new tissues can be obtained from β / tricalcium phosphate. The junction between calcium implant and tissue grows along the surface of the implant or the penetrating pores inside. However, it has the disadvantages of poor toughness, high brittleness, low mechanical strength, and poor fatigue resistance, and it is difficult to process it into a thin artificial cornea with a certain curvature. [0003] Graphite is a typical layered structure, and the layers are combined by van der W...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61L27/16A61L27/12A61L27/08A61L27/56A61L27/52
Inventor 周莉罗仲宽周金生姚晓明于莉欧阳君君郑家庆
Owner 深圳华明生物科技有限公司
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