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Hard tissue substitute material and preparation method thereof

A hard tissue and substrate technology, applied in medical science, coatings, prostheses, etc., to achieve fast and stable bonding, simple preparation process, and good repeatability

Inactive Publication Date: 2013-02-13
SHANGHAI INST OF CERAMIC CHEM & TECH CHINESE ACAD OF SCI
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

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Problems solved by technology

However, there are still few hard tissue replacement materials with high stability and excellent biological activity available on the market.

Method used

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  • Hard tissue substitute material and preparation method thereof
  • Hard tissue substitute material and preparation method thereof
  • Hard tissue substitute material and preparation method thereof

Examples

Experimental program
Comparison scheme
Effect test

Embodiment

[0027] Use hydroxyapatite powder (commercially available) with a particle size of 20-80 microns and tantalum powder (commercially available) with a particle size of 5-50 microns, mix them by ball milling for 1-4 hours, and set aside; among them, use different tantalum content Two kinds of tantalum-hydroxyapatite composite coatings were prepared, specifically: HA80wt% / Ta20wt% coating (hereinafter referred to as: H8T2) and HA40wt% / Ta60wt% coating (hereinafter referred to as: H4T6).

[0028] The vacuum plasma spraying process was used to prepare the above mixed powder coating on the titanium alloy substrate after surface pretreatment such as cleaning and sandblasting; wherein, the vacuum plasma spraying process parameters are shown in Table 1.

[0029] Table 1 Vacuum plasma spraying process parameters

[0030] Arc plasma gas Ar / slpm*

[0031] figure 1 The photographs of the surface topography of the prepared composite coating are given by figure 1 It can be seen that ...

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Abstract

The invention discloses a hard tissue substitute material and a preparation method thereof. The material comprises a coating and a base material, wherein the base material is medical metal or medical metal alloy; and the coating is attached over the base material and consists of tantalum-hydroxyapatite powder. The preparation method of the material comprises the following steps: preparing tantalum-hydroxyapatite powder; and preparing a tantalum-hydroxyapatite coating on the base which is subjected to surface pretreatment by a vacuum plasma coating technology. The hard tissue substitute material is provided with a composite coating surface which is suitable for cell adhesion and growth and fixing an implant in a hard tissue; the composite coating is excellent in bioactivity, has strong combining strength and stability with the metal base material; and quick and stable combination between the implant and the bone tissue and subsequent long-term use can be favored. The hard tissue substitute material has the advantages of being simple in preparation process, high in efficiency, good in repeatability, suitable for large-scale industrial production and the like.

Description

technical field [0001] The invention relates to a hard tissue substitute material and a preparation method thereof, in particular to a hard tissue substitute material with a tantalum-hydroxyapatite composite coating and a preparation method thereof, belonging to the technical field of medical biomaterials. Background technique [0002] Metal materials have a long history of application in medicine, and are the earliest biomaterials to be used. They have high strength and toughness and are suitable for the repair of hard tissue systems. At present, medical metal materials and their products still account for 45-50% of the total biomaterial products market. With the increase of clinical use of metal materials, the deficiencies of these materials are gradually exposed. Because metal materials are biologically inert materials, they do not have biological activity, and cannot directly bond with bone tissue in vivo; Corrosion causes the diffusion of metal ions to the surrounding ...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61L27/32A61L27/04A61L27/06
Inventor 黄利平谢有桃季珩郑学斌
Owner SHANGHAI INST OF CERAMIC CHEM & TECH CHINESE ACAD OF SCI
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