Molecularly imprinted membrane for chiral separation and preparation method thereof

Abstract

The invention discloses a molecularly imprinted membrane with a selective-separation chiral drug and a preparation method of the membrane. According to the invention, D-naproxen is taken as template molecules, a PVDF (Polyvinylidene Fluoride) hollow fiber separation membrane is taken as a base material, and the D-naproxen imprinted molecules are packaged in a fenestra grafting gel layer in a surface finish process to prepare the D-naproxen imprinted PVDF hollow fiber membrane. The molecularly imprinted separation membrane prepared by the method has good adsorption and separation functions to naproxen chiral drug molecules, has a desorption rate up to 90%-95.78%, can realize the intelligent regulation and control on combination and release of D-naproxen and solves the problem of uncontrollability on the shape and size of cavities and the affinity of template molecules of the conventional molecularly imprinted membrane. According to the invention, the mature PVDF hollow fiber membrane on the market is taken as a base membrane of the molecularly imprinted membrane, and an N-isopropyl acrylamide monomer (NIPAAm) of the conventional thermo-sensitive hydrogel is taken as a functional monomer; and the preparation method is simple, low in production cost as not needing special equipment, and suitable for industrialized application.

Description

technical field

[0001] The invention belongs to the field of functional polymer materials, and in particular relates to a molecularly imprinted membrane capable of selectively separating chiral drugs and a preparation method thereof. The membrane can be applied to the field of separating chiral drugs of naproxen. Background technique

[0002] Naproxen is a non-steroidal anti-inflammatory, antipyretic, and analgesic drug. It is mainly used for the treatment of rheumatoid arthritis, rheumatic spondylitis, and postoperative pain relief. It is one of the most widely used prescription drugs in the world. one. Naproxen exists a pair of optically active enantiomers (D-naproxen and L-naproxen), wherein D-naproxen has therapeutic effect, while L-naproxen can bring great pain of. However, during the synthesis of naproxen, D-naproxen and L-naproxen are often mixed together, and the anti-inflammatory activity of D-naproxen in the body is more than 30 times that of L-naproxen. It is o...