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Molecularly imprinted membrane for chiral separation and preparation method thereof

A molecularly imprinted membrane, chiral separation technology, applied in chemical instruments and methods, other chemical processes, etc., can solve the problems of affinity elution and recombination cannot be effectively controlled, the size of affinity regulation and other problems, to achieve production Low cost, simple preparation method and good desorption effect

Inactive Publication Date: 2013-03-13
TIANJIN POLYTECHNIC UNIV
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

However, for certain molecularly imprinted membranes and template molecules, the magnitude of this affinity is difficult to adjust according to needs, so that the influence of affinity on elution and recombination cannot be effectively controlled.

Method used

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Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0034](1) Prepare a 2.5mol / L KOH alkali solution, add 2g / L tetrabutylammonium bromide to it, put the PVDF hollow fiber membrane into the prepared alkali solution and treat it at 40°C for 5min, after alkali treatment , soak the membrane in absolute ethanol for use;

[0035] (2) Preparation of pre-polymerization solution:

[0036] 1) D-naproxen is added in dehydrated alcohol and fully stirred to make it to dissolve completely, is configured into the solution that D-naproxen concentration is 0.1mol / L, and the mass ratio of described D-naproxen and PVDF is 0.05:1;

[0037] 2) Add functional monomer N-isopropylacrylamide (NIPAAm) to the solution in step 1), stir thoroughly for 4 hours, and prepare a solution with a concentration of N-isopropylacrylamide of 1 mol / L;

[0038] 3) Slowly add the cross-linking agent ethylene glycol dimethacrylate (EGDMA) to the solution in step 2), blow nitrogen gas for 10 minutes while stirring, and configure a solution with a concentration of ethyle...

Embodiment 2

[0043] (1) Prepare a 2.5mol / L KOH alkali solution, add 2g / L tetrabutylammonium bromide to it, put the PVDF hollow fiber membrane into the prepared alkali solution and treat it at 75°C for 8min, after alkali treatment , soak the membrane in absolute ethanol for use;

[0044] (2) Preparation of pre-polymerization solution:

[0045] 1) D-naproxen is added in dehydrated alcohol and fully stirred to make it to dissolve completely, is configured into the solution that D-naproxen concentration is 0.2mol / L, and the mass ratio of described D-naproxen and PVDF is 0.25:1;

[0046] 2) Add functional monomer N-isopropylacrylamide (NIPAAm) to the solution in step 1), stir thoroughly for 9 hours, and prepare a solution with a concentration of N-isopropylacrylamide of 1 mol / L;

[0047] 3) Slowly add the cross-linking agent ethylene glycol dimethacrylate (EGDMA) to the solution in step 2), blow nitrogen gas for 10 minutes while stirring, and configure a solution with a concentration of ethyl...

Embodiment 3

[0052] (1) Prepare a 2.5mol / L KOH alkali solution, add 4g / L tetrabutylammonium bromide to it, put the PVDF hollow fiber membrane into the prepared alkali solution and treat it at 50°C for 5min, after alkali treatment , soak the membrane in absolute ethanol for use;

[0053] (2) Preparation of pre-polymerization solution:

[0054] 1) D-naproxen is added in dehydrated alcohol and fully stirred to make it to dissolve completely, is configured into the solution that D-naproxen concentration is 0.15mol / L, and the mass ratio of described D-naproxen and PVDF is 0.15:1;

[0055] 2) Add functional monomer N-isopropylacrylamide (NIPAAm) to the solution in step 1), stir thoroughly for 6 hours, and prepare a solution with a concentration of N-isopropylacrylamide of 1 mol / L;

[0056] 3) Slowly add the cross-linking agent ethylene glycol dimethacrylate (EGDMA) to the solution in step 2), blow nitrogen gas for 10 minutes while stirring, and configure a solution with a concentration of ethy...

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Abstract

The invention discloses a molecularly imprinted membrane with a selective-separation chiral drug and a preparation method of the membrane. According to the invention, D-naproxen is taken as template molecules, a PVDF (Polyvinylidene Fluoride) hollow fiber separation membrane is taken as a base material, and the D-naproxen imprinted molecules are packaged in a fenestra grafting gel layer in a surface finish process to prepare the D-naproxen imprinted PVDF hollow fiber membrane. The molecularly imprinted separation membrane prepared by the method has good adsorption and separation functions to naproxen chiral drug molecules, has a desorption rate up to 90%-95.78%, can realize the intelligent regulation and control on combination and release of D-naproxen and solves the problem of uncontrollability on the shape and size of cavities and the affinity of template molecules of the conventional molecularly imprinted membrane. According to the invention, the mature PVDF hollow fiber membrane on the market is taken as a base membrane of the molecularly imprinted membrane, and an N-isopropyl acrylamide monomer (NIPAAm) of the conventional thermo-sensitive hydrogel is taken as a functional monomer; and the preparation method is simple, low in production cost as not needing special equipment, and suitable for industrialized application.

Description

technical field [0001] The invention belongs to the field of functional polymer materials, and in particular relates to a molecularly imprinted membrane capable of selectively separating chiral drugs and a preparation method thereof. The membrane can be applied to the field of separating chiral drugs of naproxen. Background technique [0002] Naproxen is a non-steroidal anti-inflammatory, antipyretic, and analgesic drug. It is mainly used for the treatment of rheumatoid arthritis, rheumatic spondylitis, and postoperative pain relief. It is one of the most widely used prescription drugs in the world. one. Naproxen exists a pair of optically active enantiomers (D-naproxen and L-naproxen), wherein D-naproxen has therapeutic effect, while L-naproxen can bring great pain of. However, during the synthesis of naproxen, D-naproxen and L-naproxen are often mixed together, and the anti-inflammatory activity of D-naproxen in the body is more than 30 times that of L-naproxen. It is o...

Claims

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Application Information

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IPC IPC(8): B01J20/29B01J20/30
Inventor 赵义平张未来王霞李金苓陈莉申向
Owner TIANJIN POLYTECHNIC UNIV
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