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Florfenicol solid dispersoid and preparation method thereof

A technology of solid dispersion and florfenicol, which can be applied to medical preparations without active ingredients, medical preparations containing active ingredients, and pharmaceutical formulas, etc., can solve the problems of inability to industrialize promotion, high cost, complicated operation process, etc. , to achieve the effect of rapid and reliable drug effect, low drug residue and simple operating conditions

Active Publication Date: 2014-04-30
JIANGXI NEW CENTURY MINXING ANIMAL HEALTH PROD CO LTD
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

Commonly used preparation methods for solid dispersions include: melting method, solvent method, melt-solvent method, surface dispersion method, etc., but all have complicated operation process, high cost, and cannot be industrialized. In order to make up for the defects of the existing technology, scientific Compatible carrier formulations and new processing methods can optimize the process flow, reduce product toxicity and side effects, reduce pollutant emissions, and improve product bioavailability on the premise of improving product solubility

Method used

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  • Florfenicol solid dispersoid and preparation method thereof

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0017] A florfenicol solid dispersion, comprising the following components by weight ratio: 12 parts of florfenicol, 48 parts of carrier;

[0018] Mix the above components well, put them in a high-pressure reactor, turn on the constant temperature circulating water bath and the metering pump, put CO2 into the heater through the buffer tank and raise the temperature to 42°C, open the intake valve, turn on the compressor, and CO2 enters the reactor , maintain a constant pressure of 17.5Mpa in the kettle, so that the excipient carrier and the drug can fully react under the action of pressure, and combine them by hydrogen bonds. Dispersion particles, and then carry out ultrafine grinding of the solid dispersion, and pass through a 400-mesh sieve to obtain a finished product;

[0019] Wherein, the carrier is composed of polyvinylpyrrolidone, polyethylene glycol 6000, mannitol, carboxypropyl methylcellulose, and β-cyclodextrin, and the weight ratio is polyvinylpyrrolidone: polyethyl...

Embodiment 2

[0021] A florfenicol solid dispersion, comprising the following components by weight ratio: 10 parts of florfenicol, 40 parts of carrier;

[0022] Mix the above components well, put them in a high-pressure reactor, turn on the constant temperature circulating water bath and the metering pump, put CO2 into the heater through the buffer tank and raise the temperature to 35°C, open the intake valve, turn on the compressor, and CO2 enters the reactor , maintain a constant pressure of 11.5Mpa in the kettle, so that the excipient carrier and the drug can fully react under the action of pressure, and combine them by hydrogen bonding. The reaction time is 5 hours. After rapid decompression, the reaction kettle is opened, and the solid dispersion prepared in the kettle is collected solid particles, and then ultrafinely pulverize the solid dispersion, and pass through a 400-mesh sieve to obtain a finished product;

[0023] Wherein, the carrier is composed of polyvinylpyrrolidone, polyet...

Embodiment 3

[0025] A florfenicol solid dispersion, comprising the following components by weight ratio: 15 parts of florfenicol, 60 parts of carrier;

[0026] Mix the above components well, put them in a high-pressure reactor, turn on the constant temperature circulating water bath and the metering pump, put CO2 into the heater through the buffer tank and raise the temperature to 60°C, open the intake valve, turn on the compressor, and CO2 enters the reactor , maintain a constant pressure of 25.5Mpa in the kettle, so that the excipient carrier and the drug can fully react under the action of pressure, and combine them by hydrogen bonding. The reaction time is 8 hours. After rapid decompression, the reaction kettle is opened, and the solid dispersion prepared in the kettle is collected. solid particles, and then ultrafinely pulverize the solid dispersion, and pass through a 400-mesh sieve to obtain a finished product;

[0027] Wherein, the carrier is composed of polyvinylpyrrolidone, polye...

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Abstract

The invention relates to a florfenicol solid dispersoid and a preparation method thereof. The solid dispersoid comprises the components of: florfenicol and a carrier. The carrier combination is reasonable, a rapid supercritical gas expansion technology and a super micro powder technology are combined to be used, an organic solvent is not required, the solubility of a product in water is greatly improved, the bioavailability is effectively improved, and bacterial diseases (which are caused by sensitive bacteria) of beasts and birds can be effectively cured. Besides, the preparation process is simple and easy to operate, the product is harmless and environment-friendly, the curative effect is excellent, and the like.

Description

technical field [0001] The invention relates to the field of veterinary medicine, in particular to a florfenicol solid dispersion and a preparation method thereof. Background technique [0002] Florfenicol (Florfenicol) is the fluoride of thiamphenicol, which belongs to the broad-spectrum antibacterial drug of chloramphenicol for veterinary medicine. It is mainly used for pigs caused by sensitive bacteria; bacterial diseases of chickens and fish, especially for respiratory Systemic infection and intestinal infection are curative. Its antibacterial mechanism is similar to that of chloramphenicol and thiamphenicol, but its antibacterial activity is significantly better than that of chloramphenicol, and it has the advantages of no side effects of aplastic anemia, no cross-resistance with humans, and no toxicity when administered according to the prescribed dosage. , so it is currently widely used clinically, such as for the treatment of respiratory tract infection, typhoid fev...

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): A61K9/00A61K31/165A61K47/40A61K47/38A61K47/36A61K47/34A61K47/32A61K47/10A61P31/04
Inventor 贾海芳舒文林江润蓓晏永新方学锋
Owner JIANGXI NEW CENTURY MINXING ANIMAL HEALTH PROD CO LTD
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