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Method for preparing surface fiber membrane of cardia stent

A technology of fibrous membrane and cardia, applied in medical science, surgery, coating, etc., can solve problems such as cardia dilatation and food passage capacity reduction, difficulty in removing cardia stents, and reduction of cardia diameter, so as to solve scar tissue hyperplasia, Reduce the occurrence of restenosis and reduce the effect of recurrence

Inactive Publication Date: 2013-03-20
SHANGHAI TENTH PEOPLES HOSPITAL +1
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

However, if the stent implantation time is too long, it will be difficult to remove the cardiac stent due to scar tissue hyperplasia after the esophageal intima and muscular layer are torn and damaged.
At the same time, the hypertrophic scar tissue also reduces the diameter of the cardia, the expansion of the cardia and the reduction of food passing capacity, which eventually leads to the recurrence of achalasia

Method used

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  • Method for preparing surface fiber membrane of cardia stent
  • Method for preparing surface fiber membrane of cardia stent
  • Method for preparing surface fiber membrane of cardia stent

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0034] Sirolimus, tetrahydrofuran, polylactic acid, and dimethyl sulfoxide are used as a drug solution in parts by weight of 2:50:5:150. Polylactic acid is fully dissolved in dimethyl sulfoxide with a magnetic stirrer to form a uniformly dispersed substrate solution, while sirolimus is added to tetrahydrofuran to form a drug solution. Under the action of magnetic stirring, the drug solution is added into the substrate solution and stirred to form a uniformly distributed and mixed degradable polymer solution containing sirolimus.

[0035] Fill the prepared polymer solution containing sirolimus degradable polymer into the syringe of the electrospinning device, and put it into the micro-syringe pump. The metal needle on the electrospinning device is connected to a high-voltage power supply, and the cardia holder is fixed on the rotating stirrer. The speed of the micro-injection pump was set at 2ml / h, the voltage was 20KV, the distance from the needle to the support was 20cm, and...

Embodiment 2

[0037] Taxol, dichloromethane, polylactide and trifluoroacetic acid are used to prepare a drug solution in parts by weight of 5:100:10:200. Fully dissolve the polylactate in trifluoroacetic acid with a magnetic stirrer to form a uniformly dispersed substrate solution, and at the same time add paclitaxel into dichloromethane to form a drug solution. Under the action of magnetic stirring, the drug solution is added into the substrate solution and stirred to form a uniformly distributed and mixed degradable polymer solution containing paclitaxel.

[0038] Fill the prepared polymer solution containing paclitaxel-degradable polymer into the syringe of the electrospinning device, and put it into the micro-syringe pump. The metal needle on the electrospinning device is connected to a high-voltage power supply, and the cardia holder is fixed on the rotating stirrer. The speed of the micro-injection pump was set at 4ml / h, the voltage was 15KV, the distance from the needle to the suppo...

Embodiment 3

[0040] Taxol, acetone, polylactide and methanol are used to prepare a drug solution in parts by weight of 1:20:3:50. Fully dissolve the polylactide in methanol with a magnetic stirrer to form a uniformly dispersed substrate solution, and at the same time add paclitaxel to acetone to form a drug solution. Under the action of magnetic stirring, the drug solution is added into the substrate solution and stirred to form a uniformly distributed and mixed degradable polymer solution containing paclitaxel.

[0041] Fill the prepared polymer solution containing paclitaxel-degradable polymer into the syringe of the electrospinning device, and put it into the micro-syringe pump. The metal needle on the electrospinning device is connected to a high-voltage power supply, and the cardia holder is fixed on the rotating stirrer. The speed of the micro-injection pump was set at 6ml / h, the voltage was 17KV, the distance from the needle to the support was 25cm, and the speed of the rotating su...

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Abstract

The invention provides a method for preparing a surface fiber membrane of a cardia stent. The method comprises the following steps of preparing a solution containing drugs; loading the solution containing the drugs in an injection syringe; putting the injection syringe in an electrostatic spinning device; spaying the solution containing the drugs onto the cardia stent by using the electrostatic spinning device; collecting the sprayed out fiber containing the drugs by the cardia stent and forming a fiber membrane on the outer surface of the stent; and performing curing treatment on the fiber membrane formed on the cardia stent. The method for preparing the surface fiber membrane of the cardia stent changes a solution of drugs capable of treating cardia achalasia to the fiber membrane coated on the cardia stent; and drugs for inhibiting cell proliferation and inflammatory responses are applied at infected parts after the cardia stent is implanted in the body, so that stenosis generation can be reduced; problems of scar tissue hyperplasia can be solved; recurrence probability of the cardia achalasia can be decreased; and clinical efficacy can be increased.

Description

Technical field [0001] The present invention involves a method of preparing drug coating on the bracket, especially a method for preparing the surface fiber membrane on the cardia stent. Background technique [0002] Achalasia of Cardia, referred to as cardiac alcohol, is the most common clinical benign esophageal dysfunctional disease.At present, conventional means of treating the disease include chest / abdominal laparoscopy surgery, intervention of balloon dilatation, and permanent / temporary stent implantation.Temporary cardia stent implantation is easily accepted by patients due to small trauma, good clinical effects, and can be repeatedly treated. [0003] China's patent CN201227338Y revealed a non -slip cardia bracket. The non -slip cardia bracket includes the drum -shaped positioning port, the speaker -shaped positioning port, the support of the network tube, and the anti -return flow.Drum -shaped positioning mouth is at the top of the cardia bracket, consisting of three con...

Claims

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Application Information

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IPC IPC(8): A61L31/10A61L31/16
Inventor 程英升常江朱悦琦崔文国
Owner SHANGHAI TENTH PEOPLES HOSPITAL