Nano photoelectronchemical sensor for detecting dopamine with high sensitivity

A sensitive detection, photoelectrochemical technology, applied in the field of analysis and detection, to achieve the effect of good selectivity and high sensitivity
CN102980929AInactive Publication Date: 2013-03-20江苏天协医疗器械有限公司
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Patent Information

Authority / Receiving Office
CN · China
Current Assignee / Owner
江苏天协医疗器械有限公司
Publication Date
2013-03-20
Estimated Expiration
Not applicable · inactive patent

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Abstract

The invention provides a nano photoelectrochemical sensor for detecting dopamine with high sensitivity. The dopamine can be deposited to the surface of an electrode by using a chemical oxidation or electrochemical oxidation method, so as to form a polymer film, so that the photocurrent intensity of a quantum dot is reduced. Compared with a most common method for measuring the dopamine by using electrochemical cyclic voltammetry, the selectivity in detection of dopamine is improved, the measurement is not interfered by common coexisting substance ascorbic acid and uric acid in relatively high concentration, and the nano photoelectrochemical sensor is the first application of a photoelectrochemical method in detection of dopamine. With the adoption of the nano photoelectrochemical sensor, the dopamine detection with high-sensitivity is realized, the linear range is 2*10<-10>mol / L to 2*10<-5>mol / L, and the detection limit is 1*10<-10>mol / L. With the adoption of the method, the detection result of the dopamine in human urine is satisfactory, so that the method has the possibility of being applied to detection of the dopamine in human urine.
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Description

Technical field:

[0001] The invention relates to the field of analysis and detection, in particular to water-soluble quantum dots as photoelectrochemical probes and their application in photoelectrochemical detection of dopamine in human urine. Background technique:

[0002] Dopamine (DA) is an important neurotransmitter in the mammalian central nervous system. The concentration distribution of dopamine in a specific area of ​​the brain directly affects the coordination of pituitary endocrine performance and is closely related to neural activity. Changes or disorders of its content can lead to certain diseases such as Parkinson's disease and schizophrenia [R.M.Wightman, L.J.May, A.C.Michael, Anal.Chem., 1988, 60, 769A-779A; A.Heinz, H .Przuntek, G.Winterer, A.Pietzcker, Nervenarzt, 1995, 66, 662-669; C.Martin, Chem.Br., 1998, 34, 40-42; J.W.Mo, B.Ogorevc, Anal.Chem., 2001, 3, 1196-1202.]. Therefore, the study of DA analysis methods is of great significance for neurophysio...

Claims

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