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Preparation for glipizide compression-coated controlled-release tablets

A technology for glipizide and coated tablets, which is applied in the field of glipizide compression-coated controlled-release tablets, can solve the problems of unfavorable large-scale production, cumbersome process and high cost, and achieves improvement of peristaltic promotion effect and maintenance of blood medicine. effect of concentration

Inactive Publication Date: 2013-03-27
CHINA PHARM UNIV +1
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0004] Osmotic pump controlled-release preparations have many steps, cumbersome process, and high cost, and organic solvents are used in the coating process, which is not conducive to large-scale production

Method used

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  • Preparation for glipizide compression-coated controlled-release tablets
  • Preparation for glipizide compression-coated controlled-release tablets
  • Preparation for glipizide compression-coated controlled-release tablets

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0028] Chip

[0029]

[0030]The above-mentioned raw materials (excluding magnesium stearate) are uniformly mixed, dried at 60°C after granulation, sieved and granulated, and then magnesium stearate is added and mixed evenly. Tablets were compressed with a single-punch tablet machine under a pressure of 30N to form core tablets (diameter=7mm) each weighing 94.5 mg. Shell

[0031]

[0032] The above-mentioned raw materials (excluding magnesium stearate) are uniformly mixed, dried at 60°C after granulation, sieved and granulated, and then magnesium stearate is added and mixed evenly. Dry-coating machine (Kikusui Cleanpress Corret 18DC) tableting under 90N pressure, the shell layer and pre-prepared tablet core were combined to form compression-coated tablets (diameter=9mm) containing glipizide 5mg each weighing 400mg .

Embodiment 2

[0034] Chip

[0035]

[0036] The above-mentioned raw materials (excluding magnesium stearate) are uniformly mixed, dried at 60°C after granulation, sieved and granulated, and then magnesium stearate is added and mixed evenly. Tablets were compressed with a single-punch tablet machine under a pressure of 30N to form core tablets (diameter=7mm) each weighing 112 mg.

[0037] Shell

[0038]

[0039] The above-mentioned raw materials (excluding magnesium stearate) are uniformly mixed, dried at 60°C after granulation, sieved and granulated, and then magnesium stearate is added and mixed evenly. Dry-coating machine (Kikusui Cleanpress Corret 18DC) tableting under 90N pressure, the shell layer and pre-prepared tablet core were combined to form a press-coated tablet (diameter=9mm) containing glipizide 5mg each weighing 410mg .

Embodiment 3

[0041] Chip

[0042]

[0043] The above-mentioned raw materials (excluding magnesium stearate) are uniformly mixed, dried at 60°C after granulation, sieved and granulated, and then magnesium stearate is added and mixed evenly. Tablets were compressed with a single-punch tablet machine under a pressure of 30N to form core tablets (diameter=7mm) each weighing 187 mg.

[0044] Shell

[0045]

[0046] The above-mentioned raw materials (excluding magnesium stearate) are uniformly mixed, dried at 60°C after granulation, sieved and granulated, and then magnesium stearate is added and mixed evenly. Dry-coating machine (Kikusui Cleanpress Corret 18DC) tableting under 90N pressure, the shell layer and pre-prepared tablet core were combined to form compression-coated tablets (diameter=9mm) containing glipizide 5mg each weighing 480mg .

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PUM

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Abstract

The invention provides a glipizide compression-coated controlled-release tablet preparation which is in the form of zero-order release for a long time, and the preparation is tablets prepared by a compression-coating technology. An indissolvable medicine, namely, glipizide, is solubilized by adopting an inclusion compound technology, and the integrated tablets are formed by pressing tablet cores and shell layers, wherein both of the tablet cores and the shell layers contain glipizide and gel-forming macromolecular substances, and disintegration-inhibiting substances capable of enhancing gel toughness are further contained in the shell layers. The glipizide compression-coated controlled-release tablets according to the invention can release medicines with a constant speed or an approximately constant speed in 24 hours in vitro and in vivo, has the characteristics of being low in cost, easy to realize mass production and the like compared with the conventional osmotic pump-type controlled-release tablet preparations on the market, and can provide a research basis and a production technology platform for the development of controlled-release preparations. The glipizide compression-coated controlled-release tablets only need to be taken once everyday, thus enhancing clinical compliance.

Description

technical field [0001] The invention relates to a glipizide press-coated controlled-release tablet, which belongs to the field of pharmaceutical preparations. The glipizide controlled-release tablet is prepared by adopting clathrate technology and press-coating technology, which presents stable and long-lasting drug release. Effective glipizide blood levels can be maintained with a single dose. Background technique [0002] Diabetes has become the third major disease that seriously endangers human health after cardiovascular and cerebrovascular diseases and malignant tumors. The chemical name of glipizide is 1-cyclohexyl-3-[p-(2-(5-methylpyrazinecarbonamide)ethyl)phenylsulfonyl]urea, which is a lipophilic weak acid , with a pKa value of 5.9, is a second-generation sulfonylurea oral hypoglycemic agent, which can reduce fasting and postprandial blood sugar, and glycosylated hemoglobin (HbAlc) by 1% to 2%. It has been used clinically since the early 1980s. Glipizide is rapidl...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K9/22A61K9/36A61K31/64A61P3/10
Inventor 吴正红黄海琴祁小乐张慧婷陈钦闻晓光王姝
Owner CHINA PHARM UNIV
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