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Starch-hyaluronic acid hemostatic agent and preparation method thereof

A technology of hyaluronic acid and hemostatic agent, which is applied in the field of medical devices, can solve problems such as unsatisfactory effects, inflammatory reactions, burns, etc., and achieve the effects of abundant output, wide sources, and various types

Inactive Publication Date: 2013-03-27
CHINA PHARM UNIV
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

The main disadvantage is that an exothermic reaction occurs during the hemostasis process, and large amounts of it can cause burns
Its residues will also cause safety problems for the body: inflammatory reactions, blockage of terminal arterial blood flow, etc.
[0008] The hemostatic agents traditionally used in China have safety problems such as unsatisfactory effects and allergic reactions, and the only new hemostatic material on the market is the blood shield in 2006, but it has side effects of exothermic damage

Method used

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  • Starch-hyaluronic acid hemostatic agent and preparation method thereof
  • Starch-hyaluronic acid hemostatic agent and preparation method thereof
  • Starch-hyaluronic acid hemostatic agent and preparation method thereof

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0015] Preparation of starch-hyaluronic acid hemostatic agent

[0016] Put 2kg of starch in a reaction tank, add 5 L of 4% (W / V) hyaluronic acid aqueous solution, turn on the stirrer, and heat to 55 ℃ ± 5 ℃, make starch fully swell to form a uniform solution, filter, add Potassium sulfate was used as an initiator in an amount of 0.1% (W / V). Continue to stir for 4h to obtain starch-hyaluronic acid reaction solution. Add the reaction solution to the material hopper of the spray dryer, set the inlet air temperature to 130°C ± 2°C, the atomization frequency to 700.0 rpm, and the constant current pump speed to 12 rpm. Turn on the spray dryer, start the induced draft fan, start heating, and wait for the air to come out. The temperature is 90℃±2℃, and the temperature of the inlet and outlet of the system is basically stable. The spray-dried material was collected to obtain 1.4 kg of starch-hyaluronic acid porous microspheres with a yield of 70%.

[0017] The starch-hyaluronic acid...

Embodiment 2

[0019] Preparation of starch-hyaluronic acid hemostatic agent

[0020] Put 2kg of starch in a reaction tank, add 5 L of 5% (W / V) hyaluronic acid aqueous solution, turn on the stirrer, and heat to 50 ° C ± 5 ° C, so that the starch is fully swollen to form a uniform solution, filtered, added Potassium sulfate was used as an initiator in an amount of 0.05% (W / V). Continue to stir for 4h to obtain starch-hyaluronic acid reaction solution. Add the reaction solution to the material hopper of the spray dryer, set the inlet air temperature to 130°C ± 2°C, the atomization frequency to 700.0 rpm, and the constant current pump speed to 12 rpm. Turn on the spray dryer, start the induced draft fan, start heating, and wait for the air to come out. The temperature is 90℃±2℃, and the temperature of the inlet and outlet of the system is basically stable. The spray-dried material was collected to obtain 1.5 kg of starch-hyaluronic acid porous microspheres with a yield of 75%.

[0021] The s...

Embodiment 3

[0023] Preparation of starch-hyaluronic acid hemostatic agent

[0024] Put 2kg of starch in a reaction tank, add 5L of 3% (W / V) hyaluronic acid aqueous solution, turn on the stirrer, and heat to 55 ° C ± 5 ° C, so that the starch is fully swollen to form a uniform solution, filtered, added Potassium sulfate was used as an initiator in an amount of 0.05% (W / V). Continue to stir for 4h to obtain starch-hyaluronic acid reaction solution. Add the reaction solution to the material hopper of the spray dryer, set the inlet air temperature to 130°C ± 2°C, the atomization frequency to 700.0 rpm, and the constant current pump speed to 12 rpm. Turn on the spray dryer, start the induced draft fan, start heating, and wait for the air to come out. The temperature is 90℃±2℃, and the temperature of the inlet and outlet of the system is basically stable. The spray-dried material was collected to obtain 1.3 kg of starch-hyaluronic acid porous microspheres with a yield of 70%.

[0025] The st...

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Abstract

The invention relates to the field of medical devices and in particular relates to a starch-hyaluronic acid hemostatic agent and a preparation method thereof. The starch-hyaluronic acid hemostatic agent is characterized in that porous microspheres which are formed by cross-linking of starch-hyaluronic acid and are of a certain particle size are taken as hemostatic materials, and the starch-hyaluronic acid hemostatic agent is an absorbable blood factor concentrating agent. The preparation method of the starch-hyaluronic acid hemostatic agent, disclosed by the invention, comprises the following steps: heating a mixed solution of starch and hyaluronic acid, then adding an initiator, and then putting into a spray dryer for spray drying so as to prepare the starch-hyaluronic acid porous microspheres, wherein the porous microspheres are characterized by showing a surface porous structure at a microscopic level and being of solid powdery substances at a macroscopic level. The starch-hyaluronic acid hemostatic agent is stored after radiation sterilization and directly applied at the bleeding part for hemostasis. The hemostatic agent has the advantages of high hemostatic performance and biodegradability.

Description

technical field [0001] The invention relates to the field of medical devices, in particular to a starch-hyaluronic acid hemostatic agent and a preparation method and application thereof. Background technique [0002] Arterial rupture and other major bleeding caused by trauma may endanger people's lives within a few minutes due to excessive blood loss, which is too late to be sent to the hospital for treatment. Therefore, it has become the leading cause of war-related deaths and the second leading cause of daily accident deaths. . Among them, hemostasis at the junction of limbs and trunk, such as neck, armpit, and groin, is the most difficult. These parts are rich in blood vessels, and it is not easy to use tourniquets and other compression bandages to stop bleeding. In addition, bleeding problems in surgical operations are also an important cause of surgical failure, especially for operations on brain, liver, spleen, lung, kidney and other solid organs and tumor lesions, wh...

Claims

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Application Information

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IPC IPC(8): A61K31/728A61K9/16A61P7/04
Inventor 柯学陈艺张益兰冯锋陆文娟
Owner CHINA PHARM UNIV
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