Orlistat tablet and preparation method thereof
A technology of orlistat and tablets, which is applied in the field of pharmaceutical preparations, can solve the problems of orlistat tablets such as poor stability, poor fluidity, and easy sticking and punching, and achieve the effects of good stability, simple preparation process, and convenient operation
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[0027] Example 1
[0028] 1.1 Preparation of orlistat phospholipid composition
[0029]
[0030] 1.2 Preparation of Orlistat Tablets
[0031]
[0032] Preparation Process
[0033] (1) Dissolve orlistat and lecithin in ethanol, add silicon dioxide, evaporate the ethanol under reduced pressure at 30°C, take out the evaporated composition, and pass through an 80 mesh sieve to obtain orlistat phospholipid lipid Body and fully combined with silica, good fluidity;
[0034] (2) Mix the above mixture with microcrystalline cellulose, crospovidone, and magnesium stearate uniformly, and directly press the tablet to obtain.
Example Embodiment
[0035] Example 2
[0036] 1.1 Preparation of orlistat phospholipid composition
[0037]
[0038] 1.2 Preparation of Orlistat Tablets
[0039]
[0040] Preparation Process
[0041] (1) Dissolve orlistat and lecithin in ethanol, add silicon dioxide, evaporate the ethanol under reduced pressure at 30°C, take out the evaporated composition, and pass through an 80 mesh sieve to obtain orlistat phospholipid lipid Body and fully combined with silica, good fluidity;
[0042] (2) Mix the above mixture with microcrystalline cellulose, crospovidone, and magnesium stearate uniformly, and directly press the tablet to obtain.
Example Embodiment
[0043] Example 3
[0044] 1.1 Preparation of orlistat phospholipid composition
[0045]
[0046] 1.2 Preparation of Orlistat Tablets
[0047]
[0048] Preparation Process
[0049] (1) Dissolve orlistat and lecithin in ethanol, add silicon dioxide, evaporate the ethanol under reduced pressure at 30°C, take out the evaporated composition, and pass through an 80 mesh sieve to obtain orlistat phospholipid lipid Body and fully combined with silica, good fluidity;
[0050] (2) Mix the above mixture with microcrystalline cellulose, crospovidone, and magnesium stearate uniformly, and directly press the tablet to obtain.
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