Flat sheet membrane for chiral separation of amino acid and preparation method thereof

A chiral separation, flat membrane technology, applied in semi-permeable membrane separation, cyanide reaction preparation, chemical instruments and methods, etc. To achieve the effect of selective and efficient adsorption and desorption, efficient selective adsorption and desorption, and improved desorption efficiency

Inactive Publication Date: 2013-04-03
TIANJIN POLYTECHNIC UNIV
View PDF2 Cites 6 Cited by
  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0006] (1) The preparation method of the temperature-sensitive chiral separation membrane is mainly the graft modification of the base membrane material, which has the disadvantages of complex modification preparation process, poor material stability after modification, and easy peeling off of the graft layer, which is difficult to obtain. Realize industrial production
[0007] (2) The temperature sensitivity of the temperature-sensitive chiral separation membrane is not obvious enough, and the intelligent control function and control stability of temperature chiral recognition and separation need to be further improved
[0008] (3) The chiral selectivity, separation efficiency, and flux of the membrane are not high, and it is difficult to achieve steady state separation
The yield of phenylalanine prepared by synthetic method is low, and it is usually extracted from natural products, but the chiral separation efficiency is currently the main problem restricting the production of L-Phe

Method used

the structure of the environmentally friendly knitted fabric provided by the present invention; figure 2 Flow chart of the yarn wrapping machine for environmentally friendly knitted fabrics and storage devices; image 3 Is the parameter map of the yarn covering machine
View more

Image

Smart Image Click on the blue labels to locate them in the text.
Viewing Examples
Smart Image
  • Flat sheet membrane for chiral separation of amino acid and preparation method thereof
  • Flat sheet membrane for chiral separation of amino acid and preparation method thereof

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0036] (1) Take a three-necked flask device, add 50ml of THF that has been treated with water removal to condense and reflux, and add NIPAAm monomer to the three-necked flask to make the NIPAAm concentration 0.1mol / L. After adding the chiral monomer AAc-L-PheEt and 0.10 g of the cross-linking agent MBAA according to the mass ratio r of 0.2, stir at 30 ° C for 30 minutes, slowly raise the temperature to 50 ° C, stabilize for 20 minutes, add 0.04 g to initiate Azobisisobutyronitrile (AIBN) was used to react at constant temperature for 6 hours. After the reaction, petroleum ether was added to the reaction solution to precipitate, and microgel P(NIPAAm-co-AAc-L-PheEt) was obtained by suction filtration. Store in a cool place.

[0037] (2) Synthesis of temperature-sensitive film-forming substances: Take 10 g of alkali-treated PVDF powder and add it to a three-necked flask, pass nitrogen gas, add solvent N, N-dimethylformamide (DMF) with 6 times the mass of PVDF, and put it in a wat...

Embodiment 2

[0041] (1) Take a three-necked flask device, add 50ml of THF that has been treated with water removal to condense and reflux, and add NIPAAm monomer to the three-necked flask to make the NIPAAm concentration 0.13mol / L. After adding the chiral monomer AAc-L-PheEt and 0.20g of the cross-linking agent MBAA according to the mass ratio r of 0.2, stir at 30°C under nitrogen for 60 minutes, slowly raise the temperature to 70°C, stabilize for 40 minutes, add 0.08g to trigger Azobisisobutyronitrile (AIBN) was used to react at constant temperature for 10 hours. After the reaction, petroleum ether was added to the reaction solution to precipitate, and microgel P (NIPAAm-co-AAc-L-PheEt) was obtained by suction filtration. Store in a cool place.

[0042] (2) Synthesis of temperature-sensitive film-forming substances: Take 10 g of alkali-treated PVDF powder and add it to a three-necked flask, pass nitrogen gas, add solvent N, N-dimethylformamide (DMF) with 12 times the mass of PVDF, and hea...

Embodiment 3

[0046] (1) Take a three-necked flask device, add 50ml of THF that has been treated with water removal to condense and reflux, and add NIPAAm monomer to the three-necked flask to make the NIPAAm concentration 0.15mol / L. After adding the chiral monomer AAc-L-PheEt and 0.1g of the cross-linking agent MBAA according to the mass ratio r of 0.2, stir at 30°C under nitrogen for 60 minutes, slowly raise the temperature to 50°C, stabilize for 30 minutes, add 0.05g to trigger Reagent azobisisobutyronitrile (AIBN), constant temperature reaction for 10 hours. After the reaction was completed, petroleum ether was added to the reaction liquid to precipitate, and the microgel P(NIPAAm-co-AAc-L-PheEt) was obtained by suction filtration, which was dried and stored in a cool place.

[0047] (2) Synthesis of temperature-sensitive film-forming substances: Take 10 g of alkali-treated PVDF powder and add it to a three-necked flask, pass nitrogen gas, add solvent N, N-dimethylformamide (DMF) with 12...

the structure of the environmentally friendly knitted fabric provided by the present invention; figure 2 Flow chart of the yarn wrapping machine for environmentally friendly knitted fabrics and storage devices; image 3 Is the parameter map of the yarn covering machine
Login to view more

PUM

PropertyMeasurementUnit
separationaaaaaaaaaa
separationaaaaaaaaaa
separationaaaaaaaaaa
Login to view more

Abstract

The invention discloses a flat sheet membrane for chiral separation of amino acid, and a preparation method thereof, and relates to the field of intelligent high polymer materials. The preparation method comprises the following steps: firstly, taking L-phenylalanine (L-Phe) as the separation target, synthesizing a chiral amino acid monomer through modification, and further copolymerizing with a thermosensitive monomer N-isopropyl acrylamide (NIPAAm) so as to synthesize chiral copolymer microgel P (NIPAAm-co-AAc-L-PheEt); secondly, carrying out graft copolymerization on the NIPAAm monomer and polyvinylidene fluoride (PVDF) by using a free radical polymerization method so as to synthesize a thermosensitive membrane making substrate PVDF-g-PNIPAAm; and finally alloying the thermosensitive chiral copolymer microgel with a thermosensitive membrane making substrate solution, so as to prepare the flat sheet membrane for chiral separation of amino acid. The flat sheet membrane has the chiral recognition and separation function and can realize the efficient separation of L-Phe by controlling the ambient temperature change. The membrane provided by the invention is simple in preparation method, needs no special equipment, is low in production cost and is applicable to industrial application; and the selective overload quantity of the prepared flat sheet membrane can be up to 15-25%, and the separation coefficient (alpha) can be up to1.5-1.8.

Description

technical field [0001] The invention belongs to the field of functional polymer materials, in particular to a chiral separation membrane capable of selectively separating amino acid chiral molecules and a preparation method thereof. The membrane can be applied in the field of separation of phenylalanine. Background technique [0002] In nature, many substances contain chiral substances, and many chiral substances are widely found in medicines and are closely related to our lives. Because different enantiomer molecules in chiral substances have different optical activity, there are obvious differences or complete opposites in optical properties, so the optical properties of enantiomer molecules are different, in terms of pharmacological activity, metabolism and toxic side effects, etc. There will be significant differences. The clinical manifestation of the drug is that one of the enantiomer molecules has certain pharmacological effects, but the other enantiomer molecule doe...

Claims

the structure of the environmentally friendly knitted fabric provided by the present invention; figure 2 Flow chart of the yarn wrapping machine for environmentally friendly knitted fabrics and storage devices; image 3 Is the parameter map of the yarn covering machine
Login to view more

Application Information

Patent Timeline
no application Login to view more
Patent Type & Authority Applications(China)
IPC IPC(8): B01D69/06B01D71/78B01D67/00C08F259/08C08F220/54C08F220/58C07C227/34C07C229/36
Inventor 赵义平张强李金苓王霞陈莉申向陈娇娇
Owner TIANJIN POLYTECHNIC UNIV
Who we serve
  • R&D Engineer
  • R&D Manager
  • IP Professional
Why Eureka
  • Industry Leading Data Capabilities
  • Powerful AI technology
  • Patent DNA Extraction
Social media
Try Eureka
PatSnap group products

Browse by: Latest US Patents, China's latest patents, Technical Efficacy Thesaurus, Application Domain, Technology Topic.

© 2024 PatSnap. All rights reserved.Legal|Privacy policy|Modern Slavery Act Transparency Statement|Sitemap