Method for extracting water-soluble haematochrome from lovastatin crystallization mother liquor
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A technology of lovastatin and crystallization mother liquor, which is applied in the field of extracting water-soluble red pigment, can solve the problems of wasting pigment resources, etc., and achieve the effect of high color price, stable color and no obvious odor
Active Publication Date: 2013-04-03
NEW FOUNDER HLDG DEV LLC +2
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[0012] As a by-product of lovastatin production, natural pigments have not yet been effectively developed, and are disposed of as production waste, wasting a large amount of pigment resources
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Embodiment 1
[0096] Take 2L of lovastatin crystallization mother liquor, concentrate in vacuum at 70-80°C, add 1L of water to concentrate to remove the organic solvent, add 2000ml of 3% NaOH solution, add water to volume 4L, stir for 2 hours for hydrolysis; adjust pH to 8.0, add 200g Perlite powder, 600ml 5% polyaluminum chloride solution, 600ml 0.1% PAM solution, stirred for 1 hour, vacuum filtered, and collected filtrate 5.5L;
[0097] Add 200g of perlite powder to the filtrate, stir and add 800ml of 6% calcium chloride solution, stir for 1 hour, filter, and collect 6L of filtrate; add 110ml of 10mol / L HCl to adjust the pH to 1.5, add 800ml of butyl acetate, stir and extract for 30 minutes , separate and collect the extract, stir and wash with 240ml 0.4mol / L HCl for 30 minutes, separate and wash the wastewater, and collect the extract; vacuum concentrate the extract at 70-80°C, add 400ml of water to continue concentrating to remove butyl acetate, and use 500ml of 1% NaOH solution was dis...
Embodiment 2
[0100] Take 2L of lovastatin crystallization mother liquor, concentrate in vacuum at 70-80°C, add 1L of water to concentrate to remove the organic solvent, add 2070ml of 3% NaOH solution, add water to volume 6L, stir and hydrolyze for 2 hours; adjust pH to 9.5, add 300g Perlite powder, 800ml 5% polyaluminum chloride solution, 800ml 0.1% PAM solution, stirred for 1 hour, vacuum filtered, and collected filtrate 5.6L;
[0101] Add 300g of perlite powder to the filtrate, stir and add 600ml of 6% calcium chloride solution, stir for 1 hour, filter, and collect 7.8L of filtrate; add 110ml of 8mol / L HCl to adjust the pH to 1.5, add 600ml of butyl acetate, stir and extract for 30 Minutes, separate and collect the extract, stir and wash with 300ml 0.4mol / L HCl for 30 minutes, separate and wash the wastewater, and collect the extract; vacuum concentrate the extract at 70-80°C, add 400ml of water and continue to concentrate to remove butyl acetate. Dissolve it with 500ml of 1% NaOH soluti...
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Abstract
The invention provides a method for extracting water-soluble haematochrome from lovastatin crystallization mother liquor. The method comprises the following steps of: 1) carrying out concentration on the lovastatin crystallization mother liquor; 2) carrying out alkaline hydrolysis on the concentrated liquor; 3) adding a first precipitator in the hydrolysis liquor so that colloidal impurities in the hydrolysis liquor are precipitated, filtering the obtained object, and collecting filter liquor; 4) adding a second precipitator in the filter liquor so that water-soluble lovastatin acid salts are converted into water-insoluble lovastatin acid salts, filtering the obtained object, and collecting filter liquor; 5) acidifying the filter liquor by using an acidifying agent until the pH value of the filter liquor is below 3.5, and carrying out organic solvent extraction so as to obtain extract liquor; 6) carrying out concentration on the extract liquor so as to obtain concentrated liquor; 7) carrying out alkalization on the concentrated liquor by using an alkali solution, filtering the obtained object, and collecting filter liquor; and 8) carrying out concentration and drying on the filter liquor so as to obtain the water-soluble haematochrome. According to the invention, water-soluble haematochrome is successfully extracted from the lovastatin crystallization mother liquor for the first time; and the method is simple in process, has low requirements for equipment, and is suitable for industrialized continuous production.
Description
technical field [0001] The invention relates to a method for extracting water-soluble red pigment from lovastatin crystallization mother liquor. Background technique [0002] Lovastatin is a hydroxymethylglutaryl-CoA reductase inhibitor class of cholesterol-lowering drugs derived from microorganisms. Because of its clear mechanism of action and remarkable clinical efficacy, it is currently an important clinical treatment for cardiovascular and cerebrovascular diseases (such as atherosclerosis and coronary heart disease) drugs. Lovastatin is a secondary metabolite of fungi, and the main industrial bacteria producing it are Aspergillus terreus, Penicillium citrinum and Monascus ruber. [0003] The chemical name of lovastatin is: (S)-2-methylbutanoic acid-(1S,3R,7S,8S,8aR)-1,2,3,7,8,8a-6H-3,7-di Methyl-8-(2-((2R,4R)-4-hydroxy-6oxo-2H-tetrahydropyranyl)-ethyl)-1-naphthyl ester. The molecular formula of lovastatin is C 24 h 36 o 5 , the molecular weight is 404.55, and the s...
Claims
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