Looking for breakthrough ideas for innovation challenges? Try Patsnap Eureka!

Shuxuening lipidosome injection

A technology of Shuxueningzhi and injection, which is applied in the field of medicine to achieve the effects of improving curative effect, improving bioavailability and increasing retention time

Inactive Publication Date: 2015-01-07
海南路易丹尼生物科技有限公司
View PDF5 Cites 0 Cited by
  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0010] However, the challenge in preparing liposomes lies in selecting the appropriate liposome composition and formulation

Method used

the structure of the environmentally friendly knitted fabric provided by the present invention; figure 2 Flow chart of the yarn wrapping machine for environmentally friendly knitted fabrics and storage devices; image 3 Is the parameter map of the yarn covering machine
View more

Image

Smart Image Click on the blue labels to locate them in the text.
Viewing Examples
Smart Image
  • Shuxuening lipidosome injection
  • Shuxuening lipidosome injection
  • Shuxuening lipidosome injection

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0037] Embodiment 1 Shuxuening liposome injection

[0038] prescription

[0039]

[0040] Preparation Process:

[0041] (1) Weigh 7g of Ginkgo biloba extract, 50g of dioleoylphosphatidylcholine, 30g of octadecylamine, 20g of polyoxyethylene alkylamine and 1g of sodium metabisulfite in a pear-shaped bottle, add 1500ml volume A mixed solution of ethanol and acetone with a ratio of 1:1 was heated and stirred at 50°C to dissolve it, and then the organic solvent was removed under reduced pressure on a rotary evaporator to form a uniform transparent phospholipid film on the bottle wall;

[0042] (2) Under the protection of nitrogen, add 1500ml citrate buffer solution with pH 6.2 to the bottle, shake gently to elute the phospholipid film and disperse it in the medium to swell and hydrate, then do gradient homogenization at 100bar to 600bar for 4~ 6 times, 0.22 μm microporous membrane filtration, made Shuxuening liposome;

[0043] (3) Add 18g of sodium chloride to the above-ment...

Embodiment 2

[0043] (3) Add 18g of sodium chloride to the above-mentioned liposome, set the volume to 2000ml, remove bacteria and heat source by ultrafiltration membrane, fill and seal under aseptic conditions, and sterilize to prepare 1000 branches of Liposome for injection liquid. Embodiment 2 Shuxuening liposome injection

[0044] prescription

[0045]

[0046] Preparation Process:

[0047] (1) Weigh 7g of Ginkgo biloba extract, 80g of dioleoylphosphatidylcholine, 60g of octadecylamine, 10g of polyoxyethylene alkylamine and 5g of sodium metabisulfite in a pear-shaped bottle, add 1500ml volume A mixed solution of ethanol and acetone with a ratio of 1:1 was heated and stirred at 50°C to dissolve it, and then the organic solvent was removed under reduced pressure on a rotary evaporator to form a uniform transparent phospholipid film on the bottle wall;

[0048] (2) Under the protection of nitrogen, add 1500ml citrate buffer solution with pH 6.2 to the bottle, shake gently to elute th...

Embodiment 3

[0050] Embodiment 3 Shuxuening liposome injection

[0051] prescription

[0052]

[0053] Preparation Process:

[0054] (1) Weigh 17.5g ginkgo leaf extract, 60g dioleoylphosphatidylcholine, 60g octadecylamine, 90g polyoxyethylene alkylamine and 3g sodium metabisulfite in a pear-shaped bottle, add 3000ml A mixed solution of ethanol and acetone with a volume ratio of 1:1 is heated and stirred at 50°C to dissolve it, and then the organic solvent is removed under reduced pressure on a rotary evaporator to form a uniform transparent phospholipid film on the bottle wall;

[0055] (2) Under the protection of nitrogen, add 3000ml citrate buffer solution with pH 6.2 to the bottle, shake gently to elute the phospholipid film and disperse it in the medium to swell and hydrate, then do gradient homogenization at 100bar to 600bar for 4~ 6 times, 0.22 μm microporous membrane filtration, made Shuxuening liposome;

[0056] (3) Add 45g of sodium chloride to the above-mentioned liposome, ...

the structure of the environmentally friendly knitted fabric provided by the present invention; figure 2 Flow chart of the yarn wrapping machine for environmentally friendly knitted fabrics and storage devices; image 3 Is the parameter map of the yarn covering machine
Login to View More

PUM

No PUM Login to View More

Abstract

The invention discloses a Shuxuening lipidosome injection. The Shuxuening lipidosome injection is mainly prepared by using a ginkgo biloba extract, dioleoylphosphocholine, octadecylamine, polyoxyethylene alkylamine, sodium metabisulfite and sodium chloride. Compared with the prior art, the Shuxuening lipidosome injection disclosed by the invention is suitable for large-scale industrial production and has the advantages that the stability and bioavailability of a preparation are greatly improved, product quality is improved and toxic and side effects are reduced.

Description

technical field [0001] The invention relates to a novel injection preparation of ginkgo leaf extract, in particular to a liposome injection of ginkgo leaf extract and a preparation method thereof, belonging to the technical field of medicine. Background technique [0002] The composition of Shuxuening injection is Ginkgo biloba extract, and its active ingredients are mainly flavonoid glycosides and terpenoid lactone active substances, including: quercetin, camellin, ginkgo triglycerides, ginkgolides, picrolactone, etc. . Ginkgo is one of the oldest plants on earth. It is a plant of the Ginkgo family Ginkgo family. This tree species has strong vitality. It is not uncommon for a tree to be thousands of years old. It can be called the "old birthday star" in the plant world. It is recorded in "Compendium of Materia Medica" that Ginkgo biloba can invigorate the heart and nourish Qi, nourish the kidney and moisten the lungs, strengthen the brain and refresh the mind, and prolong ...

Claims

the structure of the environmentally friendly knitted fabric provided by the present invention; figure 2 Flow chart of the yarn wrapping machine for environmentally friendly knitted fabrics and storage devices; image 3 Is the parameter map of the yarn covering machine
Login to View More

Application Information

Patent Timeline
no application Login to View More
Patent Type & Authority Patents(China)
IPC IPC(8): A61K9/127A61K36/16A61K47/34A61P9/10A61P9/14A61P11/00A61K47/18A61K47/24
Inventor 王平
Owner 海南路易丹尼生物科技有限公司
Who we serve
  • R&D Engineer
  • R&D Manager
  • IP Professional
Why Patsnap Eureka
  • Industry Leading Data Capabilities
  • Powerful AI technology
  • Patent DNA Extraction
Social media
Patsnap Eureka Blog
Learn More
PatSnap group products

Browse by: Latest US Patents, China's latest patents, Technical Efficacy Thesaurus, Application Domain, Technology Topic, Popular Technical Reports.

© 2024 PatSnap. All rights reserved.Legal|Privacy policy|Modern Slavery Act Transparency Statement|Sitemap|About US| Contact US: help@patsnap.com