Norethisterone acetate-containing compound estradiol transdermal sustained release preparation and preparation method thereof

A technology of norethisterone acetate and compound estradiol, which is applied in the field of medicine, can solve problems such as embarrassment in the promotion and use of estrogen, stimulation of endometrial hyperplasia, etc., and achieves avoiding the phenomenon of peak and valley of blood drug concentration, decrease of blood drug concentration, The effect of reducing side effects
CN103054879BActive Publication Date: 2014-09-17ZHEJIANG YATAI PHARMA
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Patent Information

Authority / Receiving Office
CN · China
Patent Type
Patents(China)
Current Assignee / Owner
ZHEJIANG YATAI PHARMA
Publication Date
2014-09-17

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Abstract

The invention discloses a norethisterone acetate-containing compound estradiol transdermal sustained release preparation and a preparation method thereof. The preparation comprises a backing layer, a protective film and a frame layer between the backing layer and the protective film, wherein the frame layer comprises an upper frame layer, a lower frame layer and a controlled release film between the upper frame layer and the lower frame layer; and the backing layer covers the surface of the lower frame layer. The upper and lower frame layers are respectively wrapped by estradiol and norethisterone acetate in a certain ratio, an intermediate frame layer is wrapped by a special transdermal patch of the controlled release film, estrogen estradiol effects in relieving or eliminating climacteric syndromes and preventing osteoporosis are fully played, and the preparation also has the characteristics of small stimulus to human bodies, small side effects, quality stability and long effective time.
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Description

technical field

[0001] The invention relates to a compound estradiol transdermal slow-release preparation and a preparation method thereof, in particular to a compound estradiol transdermal slow-release preparation containing norethindrone acetate and a preparation method thereof, belonging to the field of medicine. Background technique

[0002] The chemical name of estradiol is: estradiol-1,3,5(10)-triene-3,17β-diol; the structural formula of estradiol is:

[0003]

[0004] The chemical name of norethindrone acetate is: 17β-hydroxyl 19-nor-17α-pregna-4-en-20-yn-3-one acetate; the structural formula of norethindrone acetate is:

[0005]

[0006] Women's climacteric syndrome is a common disease in women. Its pathogenesis is related to ovarian dysfunction and decreased estrogen secretion. In 1987, the Swiss Ciba Pharmaceutical Company first successfully developed the estrogen transdermal therapy system Estraderm TTS administered through the skin route as estrogen repla...

Claims

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