Application of salvianolic acid A composition in preparing medicines for improving neural function symptom after cerebral ischemia

A nerve function and salvianolic acid technology, applied in the field of salvianolic acid A composition, can solve the problems of difficult separation and purification, low natural content of salvianolic acid A, and high cost of raw medicinal materials

Active Publication Date: 2013-05-08
JIANGZI QINGFENG PHARMACEUTICALS INC
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0007] However, the use of existing preparations related to cardiovascular and cerebrovascular diseases blindly pursues to increase the purity or content of salvianolic acid A in the preparation, while ignoring the attempt to explore whether the combination of salvianolic acid A and other related ingredients can achieve the same or even better effec

Method used

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  • Application of salvianolic acid A composition in preparing medicines for improving neural function symptom after cerebral ischemia
  • Application of salvianolic acid A composition in preparing medicines for improving neural function symptom after cerebral ischemia
  • Application of salvianolic acid A composition in preparing medicines for improving neural function symptom after cerebral ischemia

Examples

Experimental program
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Effect test

Embodiment 1

[0120] Take Danshen medicinal material, crush it into 6-mesh granules, add 7 times the amount of 92°C water each time, warm soak and extract 3 times, and stir at a speed of 25 rpm, and warm soak and extract for 3 hours each time; the extract is concentrated under reduced pressure to relative Density 1.20 (60°C), add ethanol to make the alcohol content at 70%, let it stand, filter, the filtrate is decompressed to recover ethanol and concentrate until it has no alcohol smell; add water to dilute to contain salvianolic acid B 20mg per 1ml, and use 10 mg of salvianolic acid B in the aqueous solution % NaOH to adjust the pH to 4.0, add 0.5% ZnCl 2 As a catalyst, heat and transform at 120°C for 4 hours, adjust the pH value of the transformation liquid to 2.5 with 20% phosphoric acid, centrifuge, concentrate the supernatant under reduced pressure to contain 3 mg of salvianolic acid A per 1 ml, and perform HPD-100 macroporous resin column chromatography For separation, the ratio of th...

Embodiment 2

[0123] Take Salvia miltiorrhiza, cut into decoction pieces, add 8 times the amount each time, soak in water at 90°C for 3 times, and stir at a speed of 20 rpm, and extract with warm soaking for 2.5 hours each time; the extract is concentrated under reduced pressure to a relative density of 1.10 (60 ℃), add ethanol to make the alcohol content at 75%, let it stand, filter, the filtrate recovers ethanol under reduced pressure and concentrates until it has no alcohol smell; add water to dilute to contain salvianolic acid B 15mg per 1ml, and use 10% potassium hydroxide in the aqueous solution Adjust pH to 5.0, add 0.6% FeCl 3 As a catalyst, heat conversion at 120°C for 3.5 hours, adjust the pH value of the conversion liquid to 2.5 with 15% hydrochloric acid, centrifuge, concentrate the supernatant under reduced pressure to contain 5 mg of salvianolic acid A per 1 ml, pass through HPD-100 macroporous resin column layer Analysis and separation, the ratio of the loading amount of salv...

Embodiment 3

[0126] Take Danshen medicinal material, crush it into 4-mesh to 10-mesh granules, add 9 times the amount each time, soak in water at 85°C for 2 times, and stir at a speed of 30 rpm, and extract with warm soaking for 3.5 hours each time; the extract is concentrated under reduced pressure to Relative density 1.18 (60°C), add ethanol to make the alcohol content 75%, let it stand, filter, the filtrate recovers ethanol under reduced pressure and concentrates until there is no alcohol smell; add water to dilute to contain salvianolic acid B 18mg per 1ml, for aqueous solution 10% sodium carbonate to adjust pH to 5.2, add 0.6% AlCl 3 As a catalyst, heat conversion at 123°C for 4.5 hours, adjust the pH value of the conversion solution to 2.8 with 15% nitric acid, centrifuge, concentrate the supernatant under reduced pressure to contain 6 mg of salvianolic acid A per 1 ml, and pass through the HPD-100B macroporous resin column Chromatographic separation, the ratio of the loading amount ...

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Abstract

The invention relates to application of a salvianolic acid A composition in preparing medicines for improving neural function symptom after cerebral ischemia. The composition is prepared from the following components in percentage by weight: 90-99% of salvianolic acid A, 0.1-3% of alkannic acid, 0.1-3% of rosmarinic acid, 0.1-3% of salvianolic acid B and 0.1-5% of salvianolic acid C.

Description

technical field [0001] The invention relates to the use of a salvianolic acid A composition for preparing a medicine for improving neurological symptoms after cerebral ischemia. technical background [0002] Cerebrovascular disease, also known as stroke, is a neurological disease caused by various causes of blood vessels supplying the brain. The main cause is cerebral arterial lumen stenosis, vasospasm, occlusion or rupture, reduced or complete blockage of blood flow, brain blood circulation and dysfunction caused by cerebral arterial system damage (such as cerebral arteriosclerosis), and brain tissue damage. A series of symptoms caused by damage. Mainly including ischemic and hemorrhagic cerebrovascular diseases. Among them (ICVD, also known as ischemic stroke) accounted for about 80%. [0003] Ischemic cerebrovascular disease refers to the degeneration, necrosis or transient loss of function of local brain tissue including nerve cells, glial cells and connecting fibers ...

Claims

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Application Information

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IPC IPC(8): A61K31/343A61K31/216A61P9/10A61P7/02A61P25/00A61P25/28A61P7/10A61P39/06C07C69/732C07C67/32
Inventor 李志勇程帆欧阳婷张功俊杨小玲蔡元魁
Owner JIANGZI QINGFENG PHARMACEUTICALS INC
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