Irreversible thermo-sensitive type aquogel and preparation method thereof

A temperature-sensitive and hydrogel technology, applied in the field of hydrogel, can solve the problems of poor comprehensive performance of irreversible temperature-sensitive hydrogel, and achieve the effects of stable thermal discoloration area, wide application range and long storage time

Active Publication Date: 2013-05-29
CHONGQING HAIFU MEDICAL TECH CO LTD
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0009] The technical problems to be solved by the present invention include, aiming at the poor comprehensive performance of existing irreversible temperature-sensitive hydrogels, providing an irreversible temperature-sensitive hydrogel with good comprehensive performance

Method used

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  • Irreversible thermo-sensitive type aquogel and preparation method thereof
  • Irreversible thermo-sensitive type aquogel and preparation method thereof

Examples

Experimental program
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Effect test

Embodiment 1

[0040] This embodiment provides an irreversible temperature-sensitive hydrogel, which contains the following components by weight percentage: 2% to 10% polyvinyl alcohol: 5% to 40% temperature sensitive indicator: 10% to 67.5% Polyol antifreeze; 25% to 60% water.

[0041] Preferably, the polyvinyl alcohol is any one of polyvinyl alcohol 2499, polyvinyl alcohol 2488, polyvinyl alcohol 2599, polyvinyl alcohol 2399, polyvinyl alcohol 1799, and polyvinyl alcohol 1788. Generally speaking, as the degree of polymerization of polyvinyl alcohol increases, the viscosity of its solution also increases, and the strength and water resistance (the ability to resist swelling, dissolution, cracking or deformation caused by water) after gelation increase, but the dissolution Decreased sex and elasticity. After comprehensive consideration of various relevant factors, polyvinyl alcohol 2499 is the most preferred, and polyvinyl alcohol 2488, polyvinyl alcohol 2599, polyvinyl alcohol 2399, polyvi...

Embodiment 2

[0049] This embodiment provides a method for preparing an irreversible temperature-sensitive hydrogel, which includes the following steps:

[0050] S01: Prepare raw materials in the following percentages by weight: 2% to 10% polyvinyl alcohol, 5% to 40% temperature sensitive indicator, 10% to 67.5% polyol antifreeze, 25% to 60% water; Wherein, polyvinyl alcohol is preferably any one of polyvinyl alcohol 2499, polyvinyl alcohol 2488, polyvinyl alcohol 2599, polyvinyl alcohol 2399, polyvinyl alcohol 1799, polyvinyl alcohol 1788, and the temperature sensitive indicator is preferably egg white or Bovine serum, water is preferably deionized degassed water, polyalcohol antifreeze is preferably ethylene glycol.

[0051] S02: Mix polyol antifreeze with water, then add polyvinyl alcohol, mix well and heat to completely dissolve polyvinyl alcohol. Preferably, after the polyol antifreeze agent is mixed with water, it can also be degassed to avoid generating air bubbles in the hydrogel p...

Embodiment 3

[0060] This embodiment provides a method for preparing an irreversible temperature-sensitive hydrogel, which includes the following steps:

[0061] Weigh respectively: 2g of polyvinyl alcohol 2499, 5ml of egg white, 67.5ml of ethylene glycol, 25ml of deionized degassed water, and 0.5g of sodium dehydroacetate.

[0062] Mix ethylene glycol and deionized degassed water and degas to remove most of the gas dissolved in the solution; then add polyvinyl alcohol 2499 and stir continuously with a stirrer at a speed of 1 rev / s; then gradually raise the temperature to 96°C, Heat and stir to dissolve for 8h, turn off the heater after complete dissolution.

[0063] Allow the solution to cool to room temperature, stirring at a speed of 0.5 rpm during the cooling process to prevent film formation on the surface.

[0064] Pour the egg whites into a beaker for degassing, then stir slowly with a magnetic stirrer for 1 hour, avoiding the generation of air bubbles as much as possible during the...

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Abstract

The invention provides irreversible thermo-sensitive type aquogel and a preparation method thereof and belongs to the technical field of aquogel. The irreversible thermo-sensitive type aquogel is nontoxic, wide in application range, long in storage time (over one year), stable in heat discoloration region, clear in boundary, strong in repeatability, simple in preparation process and suitable for large-scale production; and the denaturation temperature can be up to about 60-65 DEG C. The irreversible thermo-sensitive type aquogel provided by the invention contains the following components in percentage by weight: 2-10% of polyvinyl alcohol, 5-40% of temperature sensitive indicator, 10-67.5% of polyhydric alcohol antifreeze agent and 25-60% of water. The preparation method of the irreversible thermo-sensitive type aquogel provided by the invention comprises the steps of freezing and unfreezing to prepare the irreversible thermo-sensitive type aquogel. The irreversible thermo-sensitive type aquogel can be applied to the medical fields including thermal therapy and thermal ablation medical fields such as a focused ultrasound therapy technology and a neoplasms/radiotherapy.

Description

technical field [0001] The invention belongs to the field of hydrogel technology, and in particular relates to an irreversible temperature-sensitive hydrogel and a preparation method thereof. Background technique [0002] Hydrogel is a gel with water as the dispersion medium. It is a polymer network system. It has characteristics similar to solid and liquid at the same time. It is soft but can maintain a certain shape and has excellent biocompatibility. Therefore, it has a very broad application prospect in the fields of drug delivery systems, bionic materials, and wound dressings. At the same time, hydrogel also has some unique properties. For example, when the external environment (PH value, temperature, light intensity, magnetic field, electric field, etc.) changes, the properties of the hydrogel can change accordingly; Changing hydrogels are called thermosensitive hydrogels. According to the different ways of responding to temperature, thermosensitive hydrogels can be d...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): C08L29/04C08L89/00C08K5/053C08J3/075
Inventor 曾涛曾德平
Owner CHONGQING HAIFU MEDICAL TECH CO LTD
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