Amoxicillin potassium clavulanate dry suspension and production process thereof

A technology of amoxicillin clavulanate potassium and clavulanate potassium, which is applied in the directions of powder delivery, antibacterial drugs, organic active ingredients, etc., can solve the problems of high transportation cost of packaging boxes, large amount of auxiliary materials, large weight and volume, etc. , to achieve the effect of high stability, less dosage and fast dissolution

Active Publication Date: 2013-06-05
贝克诺顿(浙江)制药有限公司
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

Although the amoxicillin clavulanate potassium dry suspension disclosed in this document effectively solves the degradation problem caused by the strong hygroscopicity of clavulanate potassium, the amount of auxiliary materials is too much, resulting in a larger weight and volume of each package of medicine. High box shipping costs

Method used

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  • Amoxicillin potassium clavulanate dry suspension and production process thereof
  • Amoxicillin potassium clavulanate dry suspension and production process thereof
  • Amoxicillin potassium clavulanate dry suspension and production process thereof

Examples

Experimental program
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Effect test

Embodiment 1

[0021] The preparation of embodiment 1 clavulanate potassium phospholipid complex

[0022] Dissolve 625g of potassium clavulanate and 650g of lecithin in chloroform, add 300g of silicon dioxide, stir thoroughly, evaporate the chloroform to dryness under reduced pressure below 40°C, take out the evaporated compound, and pass through a 60-80 mesh sieve to obtain Potassium clavulanate phospholipid complex with silica.

Embodiment 2

[0024] Dissolve 625g of potassium clavulanate and 500g of distearoylphosphatidylcholine in chloroform, add 200g of silicon dioxide, stir well, evaporate the chloroform to dryness under reduced pressure below 40°C, take out the evaporated complex, and pass 60- 80 mesh sieve to obtain the silicon dioxide-containing potassium clavulanate phospholipid complex.

Embodiment 3

[0025] The preparation of embodiment 3 amoxicillin clavulanate potassium dry suspension

[0026]

[0027] Preparation Process:

[0028] (1) Weigh 250g of dried amoxicillin, 10g of carboxypropyl methylcellulose, 7g of sodium lauryl sulfate, 1.5g of aspartame, 10g of coconut essence, 10g of apple essence and 4.5g of magnesium stearate , pulverized, and sieved with 60-80 mesh for later use;

[0029] (2) Weigh 158 g of the silicon dioxide-containing potassium clavulanate phospholipid complex prepared in Example 1, and set aside;

[0030] (3) Amoxicillin, silicon dioxide-containing potassium clavulanate phospholipid complex, carboxypropyl methylcellulose, sodium lauryl sulfate, aspartame, coconut flavor, apple flavor and stearic acid Pour the magnesium into a mixer and mix evenly to obtain a dry suspension.

[0031] Get the dry suspension of amoxicillin and clavulanate potassium prepared by this example, take 1L of 0.07mol / L hydrochloric acid solution as the dissolution mediu...

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Abstract

The invention discloses amoxicillin potassium clavulanate dry suspension and a production process thereof. The amoxicillin potassium clavulanate dry suspension is prepared from amoxicillin, potassium clavulanate, hydroxy propyl methylcellulose and the like in a mixing manner. The amoxicillin potassium clavulanate dry suspension has good compliance to a user.

Description

technical field [0001] The invention belongs to the technical field of pharmaceutical preparations, and relates to an oral solid preparation of amoxicillin and clavulanate potassium, in particular to a dry suspension containing amoxicillin and clavulanate potassium (4:1) and a production process thereof. Background technique [0002] Amoxicillin is a broad-spectrum penicillin antibiotic, and potassium clavulanate itself has only weak antibacterial activity, but it has a strong broad-spectrum β-lactamase inhibitory effect. The combination of the two can protect amoxicillin from β-lactamase hydrolysis. Amoxicillin-clavulanate potassium compound preparations have good effects on enzyme-producing Staphylococcus aureus, Staphylococcus epidermidis, coagulase-negative staphylococci and enterococci, and have good effects on certain β-lactamase-producing Enterobacteriaceae bacteria, Haemophilus influenzae, Moraxella catarrhalis, Bacteroides fragilis, etc. also have good antibacteria...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K31/43A61K31/424A61K9/14A61P31/04
Inventor 不公告发明人
Owner 贝克诺顿(浙江)制药有限公司
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