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Method for preparing P(SMA-co-DM) in micro-reactor through free radical polymerization

A micro-reactor, sma-co-dm technology, applied in the field of polymer materials, can solve the problems of wide molecular weight distribution and low conversion rate, and achieve the effect of reducing power loss and simplifying structure

Inactive Publication Date: 2013-06-05
JIANGNAN UNIV
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

The preparation of amphiphilic random copolymers is relatively simple, but there are a series of problems such as low conversion rate and wide molecular weight distribution.

Method used

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  • Method for preparing P(SMA-co-DM) in micro-reactor through free radical polymerization
  • Method for preparing P(SMA-co-DM) in micro-reactor through free radical polymerization
  • Method for preparing P(SMA-co-DM) in micro-reactor through free radical polymerization

Examples

Experimental program
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Effect test

example 1

[0024] Take by weighing hydrophobic monomer SMA 5mmoL, measure solvent dioxane 10mL, dissolve evenly, obtain A solution; Take by weighing initiator AIBN0.7mmoL, DM 30mmoL, and initiator is dissolved in hydrophilic monomer DM, obtain B liquid; the reaction materials, liquid A and liquid B, are respectively sent to the two injection ports of the microreactor synchronously through a single-channel micro-injection pump, and the flow rate of liquid A is set to 15ml / h, and the flow rate of liquid B is set to 10ml / h. Reaction 24h in constant temperature water bath, the conversion rate of product is 95%, the M of GPC survey w =25100, M n =22800, M w / M n = 1.1.

example 2

[0026] Take by weighing hydrophobic monomer SMA 6mmoL, measure solvent dioxane 12mL, dissolve evenly, obtain A solution; Take by weighing initiator AIBN0.8mmoL, DM 34mmoL, and initiator is dissolved in the hydrophilic monomer DM, obtain B liquid; the reaction materials, liquid A and liquid B, are respectively sent to the two injection ports of the microreactor synchronously through a single-channel micro-injection pump, and the flow rate of liquid A is set to be 13ml / h, and the flow rate of liquid B is set to be 8ml / h. Reaction 24h in constant temperature water bath, the conversion rate of product is 96%, the M of GPC survey w =24000, M n =21400, M w / M n = 1.12.

example 3

[0028] Take by weighing hydrophobic monomer SMA 6mmoL, measure solvent dioxane 14mL, dissolve evenly, obtain A liquid; Take by weighing initiator AIBN0.6mmoL, DM 24mmoL, and initiator is dissolved in hydrophilic monomer DM, obtain B liquid; the reaction materials, liquid A and liquid B, are respectively sent to the two injection ports of the microreactor synchronously through a single-channel micro-injection pump, and the flow rate of liquid A is set to be 13ml / h, and the flow rate of liquid B is set to be 7ml / h. Reaction 24h in constant temperature water bath, the conversion rate of product is 93%, the M of GPC survey w =23000, M n =21300, M w / M n = 1.08.

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Abstract

The invention belongs to the field of random copolymer preparation, and particularly relates to a method for preparing an amphiphilic random copolymer P(SMA-co-DM) in a micro-reactor through free radical polymerization. A hydrophobic monomer SMA in the P(SMA-co-DM) has a long chain pendant group, such that the polymer easily forms a vesicle-shaped micelle in the subsequent self-assembly, and the property can be used in drug slow-release carriers, biomolecules and other fields; and a hydrophilic monomer DM has pH sensitivity and temperature sensitivity, and a morphology of a micelle can be controlled in copolymer self-assembly by changing a pH value and a temperature so as to provide a good prospect. In the prior art, amphiphilic random copolymer preparation is simple, but a series of problems such as low conversion rate, wide molecular weight distribution and the like exist. The micro-reactor provides great advantages in amphiphilic random copolymer preparation. In addition, a linear size of the channel is reduced to a micron size, and the whole volume of the micro-reactor is small, such that the operation is controllable, the safety is strong, and the operation is flexible.

Description

technical field [0001] The invention belongs to the field of polymer materials, in particular to a method for free radical polymerization of amphiphilic random copolymer P(SMA-co-DM) in a microreactor. Background technique [0002] In the past ten years, scientists specialized in polymers have conducted a lot of meaningful research on amphiphilic polymers. Amphiphilic polymers refer to two phases with different properties (such as water phase and oil phase, two phases) in the same polymer. An oil phase, two incompatible solid phases) all have affinity polymers. Although the history of research on amphiphilic polymers is not long, many hotspots are currently being studied, such as nanomaterials (L.B film), liquid crystals (side-chain polymer liquid crystals), drug targeting and sustained release, and polymer alloys (phase solvents). , tertiary oil recovery and adhesives in the chemical industry, emulsion polymerization and dispersion polymerization are closely related to amp...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): C08F220/34C08F220/18C08F2/01
Inventor 陈美玲陈姗姗汪理想耿志鑫刘晓亚
Owner JIANGNAN UNIV
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