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Method for preparing lanthanum carbonate by reaction of subcritical carbon dioxide and lanthanum oxide

A technology of carbon dioxide and lanthanum oxide, applied in chemical instruments and methods, inorganic chemistry, rare earth metal compounds, etc., can solve the problems of high cost, many by-products, troublesome operation, etc., and achieve low cost, broad market prospect, and easy operation Effect

Inactive Publication Date: 2014-10-08
JISHOU UNIVERSITY
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0004] At present, the preparation methods of lanthanum carbonate mainly include urea reflux method, ammonium bicarbonate precipitation method, sodium carbonate and lanthanum chloride reaction method and sodium bicarbonate and lanthanum chloride reaction method, etc., but these methods all need to go through multi-step chemical reactions, There are many steps, troublesome operation, many by-products, and high cost. Therefore, it is necessary to develop a new preparation method for lanthanum carbonate to meet the needs of the pharmaceutical industry for lanthanum carbonate.

Method used

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Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0015] Put the lanthanum oxide rare earth raw material with a mass fraction of 81% and a 60-mesh sieve into the reactor. During the reaction, the temperature of the reactor is controlled to be 26° C., the pressure is 5.2 Mpa, and the mass fraction of carbon dioxide used is 99.6%. Forced circulation, after 25 hours of reaction, lanthanum carbonate was produced in the reactor.

[0016] The lanthanum carbonate obtained by the above method has a mass fraction of 15%.

Embodiment 2

[0018] The lanthanum rare earth raw material with a mass fraction of 90% and a 160-mesh sieve was loaded into the reactor. During the reaction, the temperature of the reactor was controlled to be 28° C., the pressure was 6.1 Mpa, and the mass fraction of carbon dioxide used was 99.7%. Forced circulation, after 40 hours of reaction, lanthanum carbonate was produced in the reactor.

[0019] The lanthanum carbonate obtained by the above method has a mass fraction of 24%.

Embodiment 3

[0021] Put the lanthanum rare earth raw material with a mass fraction of 99% and pass through a 280 mesh sieve into the reactor. During the reaction, the temperature of the reactor is controlled to be 30°C and the pressure is 7.2Mpa. The mass fraction of carbon dioxide used is 99.8%. Forced circulation, after 55 hours of reaction, lanthanum carbonate was produced in the reactor.

[0022] The lanthanum carbonate obtained by the above method has a mass fraction of 33%.

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Abstract

The invention discloses a method for preparing lanthanum carbonate by reacting subcritical carbon dioxide and lanthanum oxide, which comprises the following steps: filling 80-99.999 wt% lanthanum oxide rare-earth raw material which has passed a 40-300-mesh sieve into a reaction kettle, and reacting for 20-60 hours to obtain the lanthanum carbonate in the reaction kettle, wherein in the reaction process, the temperature of the extraction kettle is controlled at 25-31 DEG C, the pressure is 5-7.4 MPa, and the carbon dioxide with the mass percent of higher than 99.5% is subjected to forced circulation. The method is simple to operate, and has the advantages of no byproduct, low cost, high product purity and no environmental pollution. The lanthanum carbonate is a novel medicine for treating hyperphosphatemia, and has wide market prospects.

Description

technical field [0001] The invention relates to a preparation method of lanthanum carbonate, in particular to a process method for preparing lanthanum carbonate by reacting subcritical carbon dioxide and lanthanum oxide. Background technique [0002] With the gradual decline of renal function and phosphorus excretion in patients with end-stage renal disease, hyperphosphatemia often occurs, and hyperphosphatemia can lead to serious complications, such as renal bone disease, hyperparathyroidism, etc. And it is positively correlated with the morbidity and mortality of cardiovascular disease in hemodialysis patients. [0003] Oral phosphate binders are currently an effective method for treating hyperphosphatemia. Lanthanum carbonate is a new type of phosphorus binder that does not contain aluminum and calcium, which has been developed in recent years and is already in the clinical application stage. The trivalent cation lanthanum contained in it has a high affinity with phospho...

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): C01F17/00
Inventor 姚茂君
Owner JISHOU UNIVERSITY