Mosaic type DNA (Deoxyribonucleic Acid) vaccine pVAXI-Hsp 70/CD 80 for preventing and immunologically treating tuberculosis

A DNA vaccine and chimeric technology, applied in the field of chimeric DNA molecules and tuberculosis vaccines, can solve the problems of unable to improve the protection level of immune population, continuous contact, poor adult effect, etc.
CN103169986AInactive Publication Date: 2013-06-26钟森 +1
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Patent Information

Authority / Receiving Office
CN · China
Current Assignee / Owner
钟森
Publication Date
2013-06-26
Estimated Expiration
Not applicable · inactive patent

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Abstract

The invention belongs to the field of biological medicine, and particularly relates to a tubercular mosaic type DNA (Deoxyribonucleic Acid) vaccine. The tubercular mosaic type DNA vaccine solves the technical problems of nonideal medicine effect and bad safety of the traditional mosaic vaccine. The technical scheme is as follows: the mosaic type DNA vaccine contains the encoding gene of HSP 70 / CD 80 mosaic protein and can express the encoding gene in vivo. After using a pVAXI carrier, the tubercular mosaic type DNA vaccine disclosed by the invention has a better effect on the prevention and treatment of tuberculosis and can especially be used for inducing stronger Th1 type reaction and better prevent and treat tuberculosis; and besides, the pVAXI carrier has kanamycin resistance, cannot cause any anaphylactic reaction and can better prevent and immunologically treat tuberculosis.
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Description

technical field

[0001] The invention belongs to the field of biomedicine, and relates to a tuberculosis vaccine, in particular to a chimeric DNA molecule capable of inducing and enhancing protective immune responses (humoral immunity and cellular immunity) in humans or animals. The DNA molecule can be used as a vaccine for the prevention and treatment of tuberculosis. Background technique

[0002] Following the first and second world wars, there were two peaks of tuberculosis recovery in the world. In the mid-1980s, the third recovery peak was formed due to the sharp deterioration of the worldwide tuberculosis epidemic. According to the "World Health Organization Bulletin", in 1996 In 2010, the number of deaths from all ages in the world, tuberculosis ranks fourth after ischemic heart disease, cerebrovascular disease and acute lower respiratory infection, and ranks first in the number of deaths caused by a single disease in the world. The highest record in history. The num...

Claims

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