Alpha-glucosidase inhibitor

A technology of glucosidase and inhibitors, which can be used in medical preparations containing active ingredients, plant raw materials, metabolic diseases, etc., and can solve the problem of interruption of message transmission, failure of insulin to bind receptors, and number of receptors that insulin cannot bind to receptors And other issues

Inactive Publication Date: 2013-07-03
KANG JIAN BIOTECH CORP LTD
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  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0008] (a) Interruption of message transmission after insulin binds to the receptor: Insulin can bind to the receptor normally, but the cells cannot receive the proper information to perform carbohydrate metabolism;
[0009] (b) Defective insulin receptors on the cell: Insulin cannot bind to the receptors or there are not enough receptors so that insulin cannot bind to the receptors and produce an effect
[0023] The α-Glucosidase inhibitors (α-Glucosidas

Method used

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  • Alpha-glucosidase inhibitor
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Examples

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Example Embodiment

[0034] In order to have a more specific understanding of the technical content, features and effects of the present invention, the detailed description is as follows in conjunction with the illustrated embodiment:

[0035] The present invention relates to a comparison of the enzyme inhibitory activity of an unsaturated fatty acid as an α-glucosidase inhibitor with the traditional known α-Glucosidase inhibitor (α-Glucosidase inhibitor). The details are as follows:

[0036] The unsaturated fatty acids related to the present invention, for example, oleic acid (Oleic acid; Ω9), linoleic acid (Linoleic acid; Ω6), α-linolenic acid (α-Linolenic acid; Ω3) are used as an α-glucoside The enzyme inhibitor (α-Glucosidase inhibitor) enzyme inhibitory activity assay; and the drugs used for the assay are: α-glucosidase (yeast, EC 3.2.1.20), α-linolenic acid and Acarbose are all purchased from Sigma- Aldrich Co. (Saint Louis, MO, USA), oleic acid was purchased from Showa Co. (Tokyo, Japan), linole...

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Abstract

The invention discloses an alpha-glucosidase inhibitor, which is mainly composed of an unsaturated fatty acid component. The invention also discloses application of the unsaturated fatty acid contained in the alpha-glucosidase inhibitor in prevention or treatment of diabetes and obesity. In the invention, the unsaturated fatty acid component is adopted as the alpha-glucosidase inhibitor, which inhibits decomposition of starch and disaccharides in the small intestine and delays the absorption of glucose, thereby achieving the purposes of preventing or treating diabetes and obesity.

Description

technical field [0001] The invention relates to the field of medicine, in particular to an alpha-glucosidase inhibitor. Background technique [0002] Diabetes mellitus is a common endocrine and metabolic disorder, and it is also a global epidemic disease, and its prevalence is increasing day by day. Epidemiological surveys show that diabetes has become another chronic disease that seriously endangers human health after cardiovascular diseases and tumors. According to statistics, the harm of diabetes to the human body is multifaceted. If the blood sugar is not well controlled for a long time, it will cause damage to various tissues and organs in the body. The main harm is concentrated in the heart, brain, kidney, blood vessels, nerves and skin. [0003] The above types of diabetes include: [0004] 1. Type 1 diabetes mellitus (T1DM) [0005] Also known as insulin-dependent diabetes mellitus (IDDM), its cause is unknown or it is a congenital genetic defect, which causes the...

Claims

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Application Information

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IPC IPC(8): A61K45/00A61K36/06A61K36/00A61K31/201A61K31/202A61P3/04A61P3/10
Inventor 黄良得苏俊翰赖敏男
Owner KANG JIAN BIOTECH CORP LTD
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