Preparation method of water-soluble magnetic targeting graphene oxide derivative and application thereof

An oxide stone, water-soluble technology, applied in chemical instruments and methods, inorganic chemistry, non-metallic elements, etc., can solve the problems of low curative effect and large side effects, and achieve the effect of good curative effect and increased concentration

Inactive Publication Date: 2013-07-03
ZHENGZHOU UNIV
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0005] In view of the above situation, in order to solve the defects of the prior art, the purpose of the present invention is to provide a preparation method and application of a water-soluble magnetic targeting graphene oxide derivative, which can effectively solve the problem of low curative effect and large side effects of the prior art. question

Method used

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Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0034] 1) Fully dissolve 50mg of graphene oxide in 20ml of a mixed solvent composed of ethylene glycol and diacetal with a volume ratio of 1:19, add 1.5g of sodium acetate and 0.54g of ferric chloride, dissolve it ultrasonically and move it to the reaction kettle 200°C for 10 hours, the reacted product was washed 3 times with 20ml of absolute ethanol each time, and washed 5 times with 25ml of ultrapure water each time, and then vacuum-dried at 60°C for 24h to obtain 85 mg of graphene oxide supported by three irons;

[0035] 2) Take 50 mg of graphene oxide loaded with ferric oxide, 200 mg of polyacetimide, 180 mg of 1-ethyl-(3-dimethylaminopropyl) carbodiimide hydrochloride, and 180 mg of N-hydroxysuccinyl Imine 110 mg, ultrasonically dispersed in 50 ml of phosphate buffer, reacted at room temperature 18-25 ° C for 24 hours, after the reaction, added 60 ml of absolute ethanol to precipitate, suction filtered, and then washed with 20 ml of absolute ethanol for 10 The second tim...

Embodiment 2

[0037] 1) Fully dissolve 54mg of graphene oxide in 21ml of a mixed solvent composed of ethylene glycol and diacetal with a volume ratio of 1:19, add 1.6g of sodium acetate and 0.58g of ferric chloride, dissolve it ultrasonically and move it to the reaction kettle 200°C for 10 hours, the product was washed 4 times with 23ml of absolute ethanol each time, and then washed 5 times with 28ml of ultrapure water each time, and then vacuum-dried at 55°C for 24h to obtain ferric oxide loaded Graphene oxide 88mg;

[0038] 2) 54mg of graphene oxide supported by the above-mentioned ferric oxide, 218mg of amino polyethylene glycol 2000, 190mg of 1-ethyl-(3-dimethylaminopropyl)carbodiimide hydrochloride, N-hydroxy Succinimide 118mg, ultrasonically dispersed in 53ml phosphate buffer, reacted at room temperature 18-25°C for 24h, after the reaction, add 80ml of absolute ethanol to precipitate, filter with suction, and then use 20ml of absolute ethanol each time , washed 10 times, and vacuum-d...

Embodiment 3

[0040] 1) Fully dissolve 45mg of graphene oxide in 18ml of a mixed solvent composed of ethylene glycol and diacetal with a volume ratio of 1:19, add 1.35g of sodium acetate and 0.48g of ferric chloride, dissolve it by ultrasonic and move it to the reaction kettle 200°C for 10 hours, the product was washed 3 times with 20ml of absolute ethanol each time, and then washed 4 times with 30ml of ultrapure water each time, and then vacuum-dried at 55°C for 36h to obtain ferric oxide loaded Graphene oxide 80mg;

[0041] 2) 52 mg of graphene oxide loaded with ferric oxide, 210 mg of glucosamine, 185 mg of 1-ethyl-(3-dimethylaminopropyl) carbodiimide hydrochloride, and 185 mg of N-hydroxysuccinimide 112mg, ultrasonically dispersed in 52ml phosphate buffer, react at room temperature 18-25°C for 24h, after the reaction, add 60ml of absolute ethanol to precipitate, filter with suction, and then wash 8 times with 25ml of absolute ethanol each time , vacuum-dried at 60° C. for 24 hours to o...

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Abstract

The invention relates to a preparation method of a water-soluble magnetic targeting graphene oxide derivative and an application thereof. The problems of low curative effect and large side effects in the prior art can be effectively solved. The technical scheme for solving the problems is as follows: loading magnetic ferroferric oxide on graphene oxide through a chemical precipitation method, and then connecting with a hydrophilic group to get the water-soluble magnetic targeting graphene oxide derivative. In the graphene oxide derivative, the weight ratio of the ferroferric oxide to the graphene oxide is 1-11:1; and the graphene oxide is nano-scale graphene oxide. The water-soluble magnetic targeting graphene oxide derivative disclosed by the invention has the advantages of good physical and chemical stability, rich sources of raw materials, low cost, good biocompatibility, slow release and targeting property, and is of an innovation in anti-tumor medicaments.

Description

technical field [0001] The invention relates to the field of chemical industry, in particular to a preparation method and application of water-soluble magnetic targeting graphene oxide derivatives. Background technique [0002] Since graphene was prepared by Giem AK and Novoselov KS of the University of Manchester in 2004, this new type of material has been known for its excellent properties, such as high mechanical strength (>1060GPa), thermal conductivity (~3000W m -1 ·K -1 ), electron mobility (15000 cm 2 ·V -1 ·s -1 ), and specific surface area (2600m 2 g -1 ), which has aroused extensive attention of scientists. Graphene is the world's thinnest two-dimensional nanomaterial composed of a single layer of carbon atoms, and is considered to be the basic structural unit of fullerenes, carbon nanotubes (CNTs), and graphite. Graphene oxide (GO) is a derivative of graphene. Its structure is roughly the same as that of graphene, except that a large number of carbonyl ...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): C01B3/00
Inventor 史进进高君王蕾刘瑞瑗张振中张静余晓媛刘艳马柔柔马丹
Owner ZHENGZHOU UNIV
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