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Traditional Chinese medicine composition for treating bronchial asthma in acute-outbreak period

A technology for bronchial asthma and acute attack, which is applied in drug combinations, medical raw materials derived from arthropods, medical raw materials derived from leeches/helminths, etc., can solve the adverse reactions and dependence that restrict clinical application, the non-regulatory effect of asthma-causing factors and other problems, to achieve the effect of improving pulmonary ventilation function, improving microcirculation and no drug resistance

Inactive Publication Date: 2013-07-10
刘冰甜
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0005] With glucocorticoids, beta 2 Although the treatment with receptor agonists and theophylline has definite curative effect, it has no regulatory effect on the asthmatic factors in plasma and is prone to many serious adverse reactions and dependence, which restricts its clinical application to a certain extent.

Method used

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Examples

Experimental program
Comparison scheme
Effect test

preparation example Construction

[0068] The present invention also provides a preparation method of the above-mentioned traditional Chinese medicine composition, specifically:

[0069] In the first step, the dogwood, scutellaria baicalensis, Chuanshegan, American ginseng, Huashan ginseng, Jinbocao and Acanthopanax were mixed according to their weight parts to obtain a mixture, crushed, and added distilled water 5 to 8 times the weight of the mixture to decoct for 2 ~4h, filter the decoction, add distilled water 2 to 4 times the mass of the mixture to the filter residue and decoct for 2~3h, filter the decoction, combine the filtrates, concentrate under reduced pressure to remove 1 / 2 to 2 / 3 of the volume of water , add ethanol with an alcohol concentration of 70% to 80% until the proportion of ethanol volume is 60% to 70%, stir while adding, let it stand for precipitation after adding, take the supernatant and concentrate under reduced pressure to recover ethanol, and concentrate to remove the solvent , to obta...

Embodiment 1

[0078] Example 1 Granule 1

[0079] Mix 40g of Cornus officinalis, 80g of Scutellaria baicalensis, 50g of Chuanshegan, 60g of American ginseng, 55g of Huashan ginseng, 45g of golden boil grass and 45g of Acanthopanax acanthopanax to obtain the mixture, crush it, add 2.4kg of distilled water to decoct for 4 hours, filter the decoction, and filter the residue again Add 1 kg of distilled water and decoct for 3 hours, filter the decoction, combine the filtrates, concentrate under reduced pressure to remove 2 / 3 volume of water, add ethanol with an alcohol concentration of 80% until the proportion of ethanol volume is 70%, add as you go Stir, add and leave to settle, take the supernatant and concentrate under reduced pressure to recover ethanol, concentrate to remove the solvent, obtain a dry paste, and pulverize it into the first powder; 30g of Tinglizi, 35g of Morus alba, 30g of Digupi, Corydalis Corydalis 40g, 35g of catechu, 25g of dried ginger, 45g of aristolochia, 35g of spide...

Embodiment 2

[0080] Embodiment 2 toxicity test

[0081] Acute Toxicity Test

[0082] Select 20 Kunming mice, half and half female, body weight (20+2) g, provided by Qingdao Experimental Animal Center, dissolve the granules prepared in Example 1 in water, prepare a 1g / ml solution, and give them for oral administration Mice, after preliminary experiments, failed to detect orally administered LD 50 , so measure its maximum tolerated dose, with the administration volume of 1.4ml / 10g body weight, gavage 2 times / d, interval 6h, observe 7d after administration, record animal death and toxic and side effect symptoms, when experiment finishes, will All animals were processed, dissected, and the lesions of the main organs and tissues were observed with the naked eye. After 2 times of gavage of 140g crude drug / kg, the animals moved, and no abnormalities were found in eating and drinking. The animals died after 7 days of observation, and no major organs were found in the autopsy. Therefore, the maxi...

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PUM

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Abstract

The invention provides a traditional Chinese medicine composition for treating bronchial asthma in the acute-outbreak period. The traditional Chinese medicine composition comprises the following raw materials: fructus corni, semen lepidii, white mulberry root-bark, radix scutellariae, cortex lycii radicis, corydalis tuber, wadalee-gum-tree, dried ginger, iris tectorum maxim, aristolochia, fewflower lysionotus herb, celandine, saffron, American ginseng, cinnamon, physochlaina macrophylla, rhodiola, acanthopanax, changium smyrnioide, sea-buckthorn, japanese inula herb, salvia miltiorrhiza, bamboo shavings, lumbricus, pinellia ternate, cassia twig and garden balsam. The traditional Chinese medicine composition has the advantages of being capable of inhibiting the inflammatory reaction, reducing the airway hyperresponsiveness state, improving the micro-circulation, improving the pulmonary ventilation function and adjusting the immune function in the acute-outbreak period of the bronchial asthma; and compared with western medicines, the traditional Chinese medicine composition has the advantages of being capable of better improving the life quality of asthma patients and reducing the usage amount of glucocorticoids, having little toxic and side effects without drug tolerance and being low in cost.

Description

technical field [0001] The invention relates to the technical field of traditional Chinese medicines, in particular to a traditional Chinese medicine composition for treating acute attack of bronchial asthma. Background technique [0002] Bronchial asthma is one of the most common chronic diseases in the world today. There are more than 300 million people suffering from asthma in the world, and there are at least tens of millions of patients in my country. Over the past ten years, the prevalence and mortality of asthma have increased in countries all over the world, especially the United Kingdom, the United States, Australia, and New Zealand. The average prevalence of asthma in my country is 0.5-1.0%, which varies from region to region. In the South, children under the age of 12 are about 2%. The course of disease of many patients is as long as more than ten years to several decades. Therefore, bronchial asthma seriously endangers the health of the broad masses of the peopl...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K36/9068A61K9/16A61K9/12A61P11/06A61K35/64A61K35/62
Inventor 刘冰甜
Owner 刘冰甜
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