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Orally disintegrating sustained-release preparation containing tamsulosin hydrochloride and preparation method thereof

A tamsulosin hydrochloride, slow-release preparation technology, applied in the field of medicine, can solve the problem of uneven content, achieve the effects of short coating time, ensure uniform content, and good slow-release effect

Inactive Publication Date: 2013-08-07
AVENTIS PHARMA HAINAN
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

The disadvantage is that the dosage of tamsulosin hydrochloride prescription is relatively small, and the vegetarian pills are prepared by extrusion and spheronization, and the excipients and raw materials are not mixed evenly, which may easily cause uneven content

Method used

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  • Orally disintegrating sustained-release preparation containing tamsulosin hydrochloride and preparation method thereof
  • Orally disintegrating sustained-release preparation containing tamsulosin hydrochloride and preparation method thereof
  • Orally disintegrating sustained-release preparation containing tamsulosin hydrochloride and preparation method thereof

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0023] prescription

[0024]

[0025] The preparation process takes the prescription amount of microcrystalline cellulose and sucrose, mixes them evenly, adds an appropriate amount of water to make a soft material, extrudes a spheronizer to prepare pellets, and passes through a 20-mesh and 30-mesh sieve after drying to obtain a blank core (0.5-0.7mm);

[0026] Coating prescription

[0027]

[0028]

[0029] The preparation process configures the coating liquid according to the prescription, weighs 100g of the blank core, puts it into a multifunctional fluidized bed, coats 10g with a 5% drug-containing layer (main content is 0.2g / 100g), and dries for 5min with 12.5% ​​uterine Odd NE30D coating 25g, get sustained-release pills with medicine:

[0030] Oral collapse prescription

[0031]

[0032] Preparation process: Weigh the prescribed amount of medicated pellets, mannitol, lactose hydrate, and powdered sugar, and mix them with a three-dimensional mixer. After the ...

Embodiment 2

[0035] prescription

[0036]

[0037] The preparation process takes the prescription amount of microcrystalline cellulose and sucrose, mixes them evenly, adds an appropriate amount of water to make a soft material, extrudes a spheronizer to prepare pellets, and passes through a 20-mesh and 30-mesh sieve after drying to obtain a blank core (0.5-0.7mm);

[0038] Coating prescription

[0039]

[0040]

[0041] The preparation process configures the coating solution according to the prescription, weighs 100g of the blank core, puts it into a multi-functional fluidized bed, coats 15g with a 5% drug-containing layer (the main content is 0.2g / 100g), and dries for 5min with 12.5% ​​uterine Odd NE30D coating 25g, get sustained-release pills with medicine:

[0042] Orally Disintegrating Tablet Prescription

[0043]

[0044] Preparation process: Weigh the prescribed amount of medicated pellets, mannitol, lactose hydrate, and microcrystalline cellulose, and mix them evenly w...

Embodiment 3

[0047] prescription

[0048]

[0049] The preparation process takes the prescription amount of microcrystalline cellulose and sucrose, mixes them evenly, adds an appropriate amount of water to make a soft material, extrudes a spheronizer to prepare pellets, and passes through a 20-mesh and 30-mesh sieve after drying to obtain a blank core (0.5-0.7mm);

[0050] Prescription with drug layer

[0051]

[0052]

[0053] The preparation process configures the coating solution according to the prescription, weighs 100g of the blank core, and puts it into In the chemical bed, 5% drug-containing layer (the main content is 0.2g / 100g) is coated with 15g, dried for 5min, NE30D coated 30g, get sustained release pills with medicine

[0054] Orally Disintegrating Tablet Prescription

[0055]

[0056] Preparation process: Weigh the prescribed amount of pills with medicine, mannitol, lactose hydrate, Vegetables, mixed with a three-dimensional mixer, mixed with the prescripti...

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Abstract

Belonging to the field of medicines, the invention particularly relates to a preparation method of a sustained release tablet containing tamsulosin hydrochloride. The dosage form is an oral preparation that is prepared by taking tamsulosin hydrochloride as an active component and using acceptable auxiliary materials in an orally disintegrating tablet. The preparation not only has the characteristics of rapid disintegrating speed, rapid onset, and high patient compliance of orally disintegrating tablets, but also has the advantages of long action time, significantly reduced adverse reactions during instantaneous release of drugs, and stable blood concentration.

Description

technical field [0001] The invention belongs to the field of medicine, and in particular relates to a slow-release preparation containing tamsulosin hydrochloride, which has the characteristics of an orally disintegrating tablet. Background technique [0002] With the acceleration of the aging society, the silver-haired group has become a group that cannot be ignored. Many senile diseases have gradually been put on the agenda. Among them, male benign prostatic hyperplasia is one of the common diseases with a high probability of occurrence. The strength of research and market development is of great significance to improving the quality of life of men and promoting the development of the middle-aged and elderly drug market. [0003] Tamsulosin hydrochloride, also known as tamsulosin hydrochloride or tamsulosin hydrochloride, the chemical name is {2-[2-(o-ethoxyphenoxy)ethylamino]propyl}-2-methoxy Benzenesulfonamide hydrochloride is a selective α-1 blocking agent for prostate...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K9/22A61K31/18A61K47/38A61P13/08
Inventor 贾煜娇任广智黄雪郭夏
Owner AVENTIS PHARMA HAINAN
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