A flexible surface-enhanced Raman spectroscopy substrate and its preparation method

A surface-enhanced Raman and substrate technology, which is used in Raman scattering, processes for producing decorative surface effects, and fabrication of microstructure devices, etc. and analysis of environmental universality and other issues, to achieve the effect of saving economic costs, macro universality and generalizability

Active Publication Date: 2015-11-18
PEKING UNIV
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

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Problems solved by technology

An important bottleneck restricting the application of SERS technology is the analysis efficiency of SERS and the universality of the analysis environment.
Usually SERS analysis experiments require cumbersome substrate preparation procedures (and possible special reagents and instruments), and the substrate is easily contaminated and inactivated and cannot be stored for a long time; Analysis environment and other constraints
The above problems hinder the promotion and application of SERS technology.

Method used

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  • A flexible surface-enhanced Raman spectroscopy substrate and its preparation method
  • A flexible surface-enhanced Raman spectroscopy substrate and its preparation method
  • A flexible surface-enhanced Raman spectroscopy substrate and its preparation method

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0029] Embodiment 1, preparation of flexible gold reinforced substrate

[0030] 1) Sacrificial template substrate cleaning: the silicon wafer substrate with a 300nm oxide layer used as a sacrificial template was ultrasonically cleaned in water, acetone, absolute ethanol and deionized water for 10 minutes, and then treated with an oxygen plasma cleaner to obtain a surface Clean hydrophilic silicon substrate.

[0031] 2) Metal active layer deposition: use vacuum thermal evaporation to deposit a uniform gold film on the surface of the substrate: put the substrate prepared in step 1) into the vacuum thermal evaporation coating system, and select the evaporation source with a purity of 99.999% % gold wire, vacuumed to about 10 3 After Pa, the control current is The rate of vapor deposition of gold film. Through a series of comparative experiments with gold film thicknesses of 0, 1, 3, 5, 8, 10, 15 and 20nm, it was found that the gold film thickness of 8nm can obtain the best en...

Embodiment 2

[0034] Example 2. Preparation of a flexible silver-reinforced substrate.

[0035] The preparation method is basically the same as that in Example 1, the difference is that in step 2), 99.999% silver bars are used as the evaporation source, and the SEM and TEM morphology characterization of the silver film is shown in Figure 5 (d), Figure 5 (e) and Figure 5 (f), it can be seen that the silver film is a discrete island structure, most of the gaps are about 5-10nm in size, but there are also many small gap structures with local gaps of 2-3nm, which meet the conditions for the formation of ideal electromagnetic enhancement effects, The extinction spectra in the visible region of gold films with different thicknesses are shown in Figure 4 (b); the baking condition in step 3) is 100°C for 10 min; after removing the sacrificial template in step 4), the SEM characterization results of the flexible silver-reinforced substrate are shown in Figure 7 (b). On the other hand, the s...

Embodiment 3

[0036] Embodiment 3, preparation and detection of flexible silver reinforced substrate

[0037] 1) Cleaning of the base of the sacrificial template: After rinsing the clean and flat aluminum foil with ethanol, set it aside.

[0038] 2) Silver active layer deposition: Step 1) The aluminum foil is put into a vacuum thermal evaporation coating system, and the silver evaporation source is a silver bar with a purity of 99.999%. Vacuum down to about 10 3 After Pa, the control current is The gold film is evaporated and deposited at a rate of 8nm, and the thickness indicated by the instrument (monitored by the crystal oscillator) is 8nm, and the composite structure of the medium layer / silver active layer supported by the sacrificial template is obtained.

[0039] 3) Encapsulation of the support layer: same as in Example 1, the baking condition is 100° C. for 10 minutes, and the thickness of the support layer is about 300 nm.

[0040] 4) Removal of the sacrificial template: 50 mL o...

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Abstract

The invention discloses a flexible surface enhanced Raman spectrum base and a preparation method thereof. The base comprises a metal active layer and a supporting layer arranged on the surface of the metal active layer, wherein the metal active layer is of a metal nano structure formed by at least one of metal, gold and copper. The preparation method disclosed by the invention comprises the following steps of: depositing the metal active layer on a sacrifice template; continually packaging the supporting layer on the metal active layer to obtain the flexible surface enhanced Raman spectrum base with a packaging structure; and removing the sacrifice template to obtain the base. The flexible SERS (Surface Enhanced Raman Spectrum) base disclosed by the invention is applicable to batch production, storage and transportation of the base and the economic cost is saved; and according to the base disclosed by the invention, the metal active layer is isolated from external environment so that inactivation and surface pollution are unlikely to happen. The commercial flexible SERS base enables an SERS analyzing method to have greater macroscopic universality and generalizability.

Description

technical field [0001] The invention relates to a flexible surface-enhanced Raman spectrum substrate and a preparation method thereof. Background technique [0002] Surface-enhanced Raman spectroscopy (SERS) technology can provide molecular fingerprint information of analytes at the single-molecule level, so it has great application value in the detection and analysis of trace species. Although the SERS effect was discovered in the 1970s, the application cases of SERS technology in real life are very limited in the past forty years. An important bottleneck restricting the application of SERS technology is the analysis efficiency of SERS and the universality of the analysis environment. Usually SERS analysis experiments require cumbersome substrate preparation procedures (and possible special reagents and instruments), and the substrate is easily contaminated and inactivated and cannot be stored for a long time; Analysis environment and other constraints. The above problem...

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): G01N21/65B81C1/00
Inventor 张锦徐伟高田中群
Owner PEKING UNIV
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