Gynecological medical gel dressing and preparation method thereof

A gel and gynecological technology, applied in medical science, bandages, absorbent pads, etc., can solve the problems of easy generation of drug resistance, easy destruction of vaginal acidic environment, unsatisfactory treatment effect, etc., to prevent and assist in the treatment of pelvic inflammatory disease, Good natural antibacterial activity, the effect of restoring normal physiological environment

Inactive Publication Date: 2013-09-18
王珍
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

Inconvenient to use, short contact time, easy to lose, and need to be wiped after washing, easy to contaminate clothes, inconvenient to carry, affect daily work; can not go deep into the lesion in the vaginal folds, especially the cervix is ​​more difficult to reach, and can not be cured Disease effect, hidden dangers, long-term use will produce a large number of new drug-resistant viruses, so that women suffering from a single gynecological inflammation will eventually become victims of multiple gynecological diseases. use
Suppositories are mostly composed of ketoconazole and nitrate azole antibiotics, which are effective against some bacteria and molds, but not effective against carcinogenic viruses; the residence time is too long (more than 6 hours), the drug is uneven, and...

Method used

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  • Gynecological medical gel dressing and preparation method thereof
  • Gynecological medical gel dressing and preparation method thereof

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0017] Weigh 383g of chitosan and put it into the mixing tank, add 24000ml of pure water, stir well, set the stirring speed of the mixer to 85--300 rpm, slowly add 235ml of lactic acid while stirring, the pH value is 3, the process takes about After 1-2 hours, slowly add 240g carbomer (dissolve it in 2700ml water first), and 2400ml glycerin, mix well, then add 240ml 10% chlorhexidine acetate solution, and finally use 0.3% sodium bicarbonate solution Slowly adjust the pH value of the chitosan solution to 5.2 with 2000ml, the process takes about 2-3 hours, filter, and vacuum equipment to remove all air bubbles, which is a semi-finished product. Measure chitosan solution pH value and film-forming material content again the next day, pH value is 5.2, obtains the gel of chitosan final concentration 1.28%, film-forming material content is 11.8%, hose syringe subpackage, carry out aseptic Test, qualified is the finished product.

Embodiment 2

[0019] Weigh 434g of chitosan and put it into the mixing tank, add 24000ml of pure water, stir well, set the stirring speed of the mixer to 85--300 rpm, slowly add 235ml of lactic acid while stirring, the pH value is 3, the process takes about After 1-2 hours, slowly add 240g carbomer (dissolve it in 3000ml water first), and 2400ml glycerin, mix well, then add 240ml 10% chlorhexidine acetate solution, and finally use 0.4% sodium bicarbonate solution Slowly adjust the pH value of the chitosan solution to 5.8 with 2800ml, the process takes about 2-3 hours, filter, and vacuum equipment to remove all air bubbles, which is a semi-finished product. Measure chitosan solution pH value and film-forming material content again the next day, pH value is 5.8, obtains the gel of chitosan final concentration 1.45%, film-forming material content is 15.6%, hose syringe subpackage, carry out aseptic Test, qualified is the finished product.

Embodiment 3

[0021] Weigh 571g of chitosan and put it into the mixing tank, add 24000ml of pure water, stir well, set the stirring speed of the mixer to 85--300 rpm, slowly add 235ml of lactic acid while stirring, the pH value is 3, the process takes about After 1-2 hours, slowly add 240g carbomer (dissolve it in 3200ml water first), and 2400ml glycerin, mix well, then add 240ml 10% chlorhexidine acetate solution, and finally use 0.5% sodium bicarbonate solution Slowly adjust the pH value of the chitosan solution to 6.4 with 3000ml, the process takes about 2-3 hours, filter, and remove all air bubbles with vacuum equipment, which is a semi-finished product. Measure chitosan solution pH value and film-forming material content again the next day, pH value is 6.4, obtains the gel of chitosan final concentration 1.73%, film-forming material content is 17.4%, hose syringe subpackage, carry out aseptic Test, qualified is the finished product.

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Abstract

The invention discloses a gynecological medical gel dressing and a preparation method thereof, and aims at providing a gynecological medical gel dressing being remarkable in effect of treating various gynecologic inflammations and capable of quickly repairing disseminated congestion, mucosal injury and superficial ulcer caused by vagina inflammatory diseases and cervical erosion. According to the technical points, the dressing comprises chitosan at a concentration of 1.25 to 2.0% and other auxiliary materials; and the preparation method comprises the following steps of: weighing chitosan and dissolving by 0.5% of lactic acid solution to obtain chitosan liquid; slowly adding carbomer accounting for 1% of the total mass and glycerinum accounting for 10% of the total mass to the chitosan liquid; uniformly stirring; adding chlorhexidine acetate accounting for 0.1% of the total mass; uniformly mixing; adjusting pH (Potential of Hydrogen) to 4.5 to 7.5 through a sodium bicarbonate solution; filtering; removing bubble through vacuum equipment to obtain a semi-finished product; detecting biological indexes and physicochemical indexes the next day; performing split charging through a hose syringe; carrying out sterility test, thus obtaining the finished product after confirmation. The gynecological medical gel dressing and the preparation method thereof belong to the technical field of pharmaceutical preparation.

Description

technical field [0001] The invention is a biological dressing, specifically, a gynecological medical gel dressing, and also relates to a preparation method of the gel dressing. Background technique [0002] Vaginal mucosal drug administration has a history of nearly a hundred years. Compared with traditional oral drugs, it has many advantages. It is an effective drug sustained release system. It can be used not only locally, but also systemically. Increase the local drug concentration, give full play to the efficacy of the drug, and avoid systemic effects; the absorption of the drug through the vaginal mucosa exerts a systemic effect, which can avoid the hepatic first-pass effect of the drug, improve bioavailability, reduce toxic and side effects, and avoid the side effect of some drugs. Gastrointestinal reactions. [0003] Common dosage forms for vaginal mucosal administration include lotions, suppositories, and effervescent tablets. Lotions are mostly Chinese herbal medi...

Claims

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Application Information

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IPC IPC(8): A61L15/28A61L15/42A61L15/24A61L15/20A61L15/44
Inventor 王珍
Owner 王珍
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