Preparation method for alanyl-glutamine biological adhesive preparation as well as product and application of preparation

A technology of alanyl glutamine and bioadhesive, applied in the field of pharmaceutical preparations, can solve the problems of reducing local immunity, strong local irritation of corrosive drugs, recurrence and the like

Active Publication Date: 2013-11-27
重庆市人民医院
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

Although these drugs have certain curative effects, they all have many shortcomings: the long-term use of broad-spectrum antibiotics and chemically synthesized antibacterial drugs also destroys the microbial balance of the oral cavity; the use of hormone drugs should be controlled within 1 week as much as possible. Excessive time may cause inhibition of the hypothalamus-pituitary-adrenal axis, and further reduce local immunity and cause recurrence; corrosive drugs are highly irritating locally, and may also inhibit the patient's vomiting reflex. and water into the respira

Method used

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  • Preparation method for alanyl-glutamine biological adhesive preparation as well as product and application of preparation
  • Preparation method for alanyl-glutamine biological adhesive preparation as well as product and application of preparation
  • Preparation method for alanyl-glutamine biological adhesive preparation as well as product and application of preparation

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0025] composition:

[0026]

[0027] Disperse hydroxypropyl methylcellulose in an appropriate amount of 80°C water for injection (preferably: 1%, w / w, hypromellose / water), wait for complete dissolution, and place it in a 4°C refrigerator to cool. The hydroxypropylmethylcellulose is a bioadhesive. In this embodiment, the hypromellose can be replaced by a certain weight of carbomer or sodium hyaluronate.

[0028] Poloxamer 407 (2.5 g) was weighed and dissolved in the above system, and then placed in a 4°C refrigerator for refrigeration until it was fully dissolved. Finally, according to the above ratio, add in sequence: alanyl glutamine, sodium gualenate, tea polyphenols, allantoin and menthol, and the product is obtained after the dissolution is complete. In this embodiment, the poloxamer 407 can also be replaced by a certain weight of chitosan, or polyethylene glycol and its esters.

[0029] In addition to good bioadhesion, the alanyl glutamine preparation prepared in t...

Embodiment 2

[0031] composition:

[0032]

[0033] Weigh 0.15g of chitosan and dissolve it in water for injection, place it at room temperature, and after it is fully swollen, disperse sodium hyaluronate in the above-mentioned chitosan aqueous solution system, and let it stand to disperse evenly. , add in sequence: alanyl glutamine, sodium gualenate, tea polyphenols, allantoin and menthol, and wait for complete dissolution to obtain the product.

[0034] The alanyl glutamine preparation prepared in this example has good bioadhesion and good biocompatibility with the ulcer surface. This is because when chitosan acts on the surface of oral ulcer, due to its amino The positively charged and negatively charged ulcer surfaces of the dextran molecules can adhere tightly for a long time, and at the same time, the drug ingredients can be released slowly, maintaining a stable drug concentration in the local area for a long time to exert a therapeutic effect. In addition, chitosan has a higher p...

Embodiment 3

[0036]

[0037] Weigh Poloxamer 407 (2.5g) and dissolve it in cold water for injection, and place it in a refrigerator at 4°C for refrigeration. After it is fully dissolved, disperse Carbomer in the above-mentioned Poloxamer 407 aqueous solution system, and let stand , to make it disperse evenly, according to the above ratio, add in sequence: alanyl glutamine, sodium gualenate, tea polyphenols, allantoin and menthol, and the product is obtained after the dissolution is complete.

[0038] The strength of the alanyl glutamine preparation prepared in this example is better, this is because carbomer can not only enhance the adhesion of the preparation, but also significantly improve the mechanical strength of the preparation.

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Abstract

The invention aims at disclosing a preparation method for an alanyl-glutamine biological adhesive preparation as well as a product and an application of the preparation. The alanyl-glutamine biological adhesive preparation is a topical gel preparation taking alanyl-glutamine as a main medicine ingredient for dental ulcer; the preparation has the characteristics of being capable of rapidly alleviating the pain of the affected parts, definite in curative effect, capable of being adhered to the surface of ulcer for a long time to protect the surface of a wound and slowly releasing medicines, less in irritation, good in biocompatibility, capable of integrating dental ulcer treatment, immune adjustment and recurrence prevention, convenient for patients to use, easy to carry and store, and low in price.

Description

technical field [0001] The invention relates to the field of pharmaceutical preparations, in particular to a bioadhesive preparation containing alanyl glutamine (Ala-Gln) for treating recurrent oral ulcers. Background technique [0002] Recurrent oral ulcers are characterized by localized oral mucosal ulcers, pain, recurrent attacks, and lingering difficulty. They are the most common oral mucosal diseases, and the incidence rate of the general population is about 20%. Because the severe pain caused by the disease often brings great pain and inconvenience to the patients, and it keeps coming and going all the year round, seriously affecting the quality of life of the patients, so the research on the prevention and treatment of the disease has important clinical value. [0003] The commonly used drugs for clinical treatment of the disease are diverse, covering antibiotics, hormones, analgesics, corrosives, digestive system drugs, biological products, vitamin drugs, and variou...

Claims

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Application Information

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IPC IPC(8): A61K38/05A61P1/02A61K36/82A61K31/4166A61K31/185A61K31/045
Inventor 车坷科刘鑫王丽娟
Owner 重庆市人民医院
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